Human Gene ACPT (uc002pta.1) Description and Page Index
  Description: Homo sapiens acid phosphatase, testicular (ACPT), mRNA.
RefSeq Summary (NM_033068): Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr19:51,293,672-51,298,481 Size: 4,810 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr19:51,293,672-51,298,415 Size: 4,744 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:51,293,672-51,298,481)mRNA (may differ from genome)Protein (426 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Testicular acid phosphatase; EC=; Flags: Precursor;
FUNCTION: Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.
CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol + phosphate.
SUBUNIT: Homodimer (Probable).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow.
INDUCTION: Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated by estrogen and progestin.
PTM: Glycosylated (Probable).
SIMILARITY: Belongs to the histidine acid phosphatase family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.16 RPKM in Testis
Total median expression: 6.16 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -11.7066-0.177 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000560 - His_Pase_superF_clade-2

Pfam Domains:
PF00328 - Histidine phosphatase superfamily (branch 2)

SCOP Domains:
53254 - Phosphoglycerate mutase-like

ModBase Predicted Comparative 3D Structure on Q9BZG2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003993 acid phosphatase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0016311 dephosphorylation
GO:0042476 odontogenesis

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AB463389 - Synthetic construct DNA, clone: pF1KB7205, Homo sapiens ACPT gene for acid phosphatase, testicular, without stop codon, in Flexi system.
BC140294 - Synthetic construct Homo sapiens clone IMAGE:100014267, MGC:173222 acid phosphatase, testicular (ACPT) mRNA, encodes complete protein.
BC146506 - Synthetic construct Homo sapiens clone IMAGE:100015046, MGC:180184 acid phosphatase, testicular (ACPT) mRNA, encodes complete protein.
JD107012 - Sequence 88036 from Patent EP1572962.
JD472002 - Sequence 453026 from Patent EP1572962.
JD409612 - Sequence 390636 from Patent EP1572962.
JD230441 - Sequence 211465 from Patent EP1572962.
JD340220 - Sequence 321244 from Patent EP1572962.
JD170762 - Sequence 151786 from Patent EP1572962.
JD170763 - Sequence 151787 from Patent EP1572962.
JD456705 - Sequence 437729 from Patent EP1572962.
JD386529 - Sequence 367553 from Patent EP1572962.
JD090144 - Sequence 71168 from Patent EP1572962.
JD365719 - Sequence 346743 from Patent EP1572962.
JD438072 - Sequence 419096 from Patent EP1572962.
JD400189 - Sequence 381213 from Patent EP1572962.
JD124713 - Sequence 105737 from Patent EP1572962.
JD417014 - Sequence 398038 from Patent EP1572962.
JD322602 - Sequence 303626 from Patent EP1572962.
JD201048 - Sequence 182072 from Patent EP1572962.
JD424176 - Sequence 405200 from Patent EP1572962.
JD424180 - Sequence 405204 from Patent EP1572962.
JD126245 - Sequence 107269 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00740 - Riboflavin metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: C0H3P7, NM_033068, NP_149059, PPAT_HUMAN, Q9BZG2, Q9BZG3, Q9BZG4
UCSC ID: uc002pta.1
RefSeq Accession: NM_033068
Protein: Q9BZG2 (aka PPAT_HUMAN)
CCDS: CCDS12802.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_033068.2
exon count: 11CDS single in 3' UTR: no RNA size: 1347
ORF size: 1281CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2762.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.