Human Gene LIPJ (uc001kff.3) Description and Page Index
  Description: Homo sapiens lipase, family member J (LIPJ), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:90,346,519-90,366,733 Size: 20,215 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr10:90,350,445-90,366,664 Size: 16,220 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:90,346,519-90,366,733)mRNA (may differ from genome)Protein (366 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkHGNC
ReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Lipase member J; EC=3.1.1.-; AltName: Full=Lipase-like abhydrolase domain-containing protein 1;
SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.48 RPKM in Testis
Total median expression: 6.87 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.50314-0.209 Picture PostScript Text
3' UTR -4.5469-0.066 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000073 - AB_hydrolase_1
IPR006693 - AB_hydrolase_lipase
IPR025483 - Lipase_euk

Pfam Domains:
PF00561 - alpha/beta hydrolase fold
PF04083 - Partial alpha/beta-hydrolase lipase region

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q5W064
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds

Biological Process:
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process

-  Descriptions from all associated GenBank mRNAs
  BC042900 - Homo sapiens lipase, family member J, mRNA (cDNA clone IMAGE:4823575), with apparent retained intron.
BC031219 - Homo sapiens lipase, family member J, mRNA (cDNA clone MGC:39509 IMAGE:4830161), complete cds.
JD489301 - Sequence 470325 from Patent EP1572962.
JD428695 - Sequence 409719 from Patent EP1572962.
JD145462 - Sequence 126486 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5W064 (Reactome details) participates in the following event(s):

R-HSA-6789310 LIPs hydrolyse TG to DAG and RCOOH
R-HSA-6809371 Formation of the cornified envelope
R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: A8MT98, LIPJ_HUMAN, LIPL1, NM_001010939, NP_001010939, Q0P671, Q5W064
UCSC ID: uc001kff.3
RefSeq Accession: NM_001010939
Protein: Q5W064 (aka LIPJ_HUMAN)
CCDS: CCDS31240.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001010939.2
exon count: 11CDS single in 3' UTR: no RNA size: 1496
ORF size: 1101CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2175.00frame shift in genome: no % Coverage: 99.20
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.