ID:ZC12D_HUMAN DESCRIPTION: RecName: Full=Probable ribonuclease ZC3H12D; EC=3.1.-.-; AltName: Full=MCP-induced protein 4; AltName: Full=Transformed follicular lymphoma; AltName: Full=Zinc finger CCCH domain-containing protein 12D; AltName: Full=p34; FUNCTION: May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation. COFACTOR: Magnesium (Potential). SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, EIF2C2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines. INDUCTION: By prolonged exposure to bacterial lipopolysaccharides (LPS) in acute monocytic leukemia cell line THP-1 cells. DISEASE: Note=A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed. SIMILARITY: Belongs to the ZC3H12 family. SIMILARITY: Contains 1 C3H1-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A2A288
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.