Human Gene GPR174 (uc004edg.1) Description and Page Index
  Description: Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.
RefSeq Summary (NM_032553): This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: AF345567.1, BC104922.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chrX:78,426,469-78,427,726 Size: 1,258 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chrX:78,426,505-78,427,506 Size: 1,002 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:78,426,469-78,427,726)mRNA (may differ from genome)Protein (333 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GP174_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 174;
FUNCTION: Putative receptor for purines coupled to G-proteins (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: GPR174
Diseases sorted by gene-association score: autoimmune polyendocrine syndrome, type ii (8), autoimmune disease of endocrine system (5)

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.23 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 18.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.3036-0.119 Picture PostScript Text
3' UTR -52.72220-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9BXC1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC104922 - Homo sapiens G protein-coupled receptor 174, mRNA (cDNA clone MGC:132582 IMAGE:8143925), complete cds.
BC104924 - Homo sapiens G protein-coupled receptor 174, mRNA (cDNA clone MGC:132584 IMAGE:8143927), complete cds.
AF345567 - Homo sapiens putative purinergic receptor (FKSG79) mRNA, complete cds.
KJ899813 - Synthetic construct Homo sapiens clone ccsbBroadEn_09207 GPR174 gene, encodes complete protein.
JD168869 - Sequence 149893 from Patent EP1572962.
JD510597 - Sequence 491621 from Patent EP1572962.
JD062098 - Sequence 43122 from Patent EP1572962.
JD360881 - Sequence 341905 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: FKSG79, GP174_HUMAN, NM_032553, NP_115942, Q2M3F7, Q9BXC1
UCSC ID: uc004edg.1
RefSeq Accession: NM_032553
Protein: Q9BXC1 (aka GP174_HUMAN or FK79_HUMAN)
CCDS: CCDS14443.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032553.1
exon count: 1CDS single in 3' UTR: no RNA size: 1258
ORF size: 1002CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2204.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.