Human Gene ZNF107 (uc003tte.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 107 (ZNF107), transcript variant 2, mRNA.
RefSeq Summary (NM_001013746): This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Transcript (Including UTRs)
   Position: hg19 chr7:64,126,511-64,171,401 Size: 44,891 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr7:64,152,320-64,169,034 Size: 16,715 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:64,126,511-64,171,401)mRNA (may differ from genome)Protein (783 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN107_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 107; AltName: Full=Zinc finger protein 588; AltName: Full=Zinc finger protein ZFD25;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Expressed in brain, heart, skeletal muscle, kidney and pancreas. Weakly expressed in aorta, liver and lung.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 25 C2H2-type zinc fingers.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF107
CDC HuGE Published Literature: ZNF107
Positive Disease Associations: Calcium
Related Studies:
  1. Calcium
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.85 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 70.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -165.52517-0.320 Picture PostScript Text
3' UTR -556.812367-0.235 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9UII5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC131762 - Homo sapiens zinc finger protein 138, mRNA (cDNA clone MGC:156242 IMAGE:40121140), complete cds.
AK303931 - Homo sapiens cDNA FLJ61041 complete cds, highly similar to Zinc finger protein 588.
BC017809 - Homo sapiens zinc finger protein 107, mRNA (cDNA clone IMAGE:4658385), partial cds.
BC047243 - Homo sapiens zinc finger protein 107, mRNA (cDNA clone MGC:47643 IMAGE:6066829), complete cds.
AB027251 - Homo sapiens mRNA for zinc finger protein (ZFD25), complete cds.
JD259380 - Sequence 240404 from Patent EP1572962.
JD259382 - Sequence 240406 from Patent EP1572962.
JD435225 - Sequence 416249 from Patent EP1572962.
JD043672 - Sequence 24696 from Patent EP1572962.
JD328851 - Sequence 309875 from Patent EP1572962.
KJ905474 - Synthetic construct Homo sapiens clone ccsbBroadEn_15067 ZNF107-like gene, encodes complete protein.
AB464751 - Synthetic construct DNA, clone: pF1KB7065, Homo sapiens ZNF107 gene for zinc finger protein 107, without stop codon, in Flexi system.
JD314876 - Sequence 295900 from Patent EP1572962.
JD314875 - Sequence 295899 from Patent EP1572962.
JD330509 - Sequence 311533 from Patent EP1572962.
JD330511 - Sequence 311535 from Patent EP1572962.
JD330510 - Sequence 311534 from Patent EP1572962.
DQ570709 - Homo sapiens piRNA piR-30821, complete sequence.
JD037677 - Sequence 18701 from Patent EP1572962.
JD314372 - Sequence 295396 from Patent EP1572962.
JD314373 - Sequence 295397 from Patent EP1572962.
JD330503 - Sequence 311527 from Patent EP1572962.
JD330504 - Sequence 311528 from Patent EP1572962.
LF340536 - JP 2014500723-A/148039: Polycomb-Associated Non-Coding RNAs.
JD330509 - Sequence 311533 from Patent EP1572962.
AB014735 - Homo sapiens mRNA for SMAP-7, partial cds.
JD282702 - Sequence 263726 from Patent EP1572962.
JD314875 - Sequence 295899 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD084020 - Sequence 65044 from Patent EP1572962.
JD330509 - Sequence 311533 from Patent EP1572962.
JD330511 - Sequence 311535 from Patent EP1572962.
JD330510 - Sequence 311534 from Patent EP1572962.
DQ570709 - Homo sapiens piRNA piR-30821, complete sequence.
JD037677 - Sequence 18701 from Patent EP1572962.
JD171386 - Sequence 152410 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD330518 - Sequence 311542 from Patent EP1572962.
JD310462 - Sequence 291486 from Patent EP1572962.
JD300333 - Sequence 281357 from Patent EP1572962.
JD051293 - Sequence 32317 from Patent EP1572962.
JD315025 - Sequence 296049 from Patent EP1572962.
JD442062 - Sequence 423086 from Patent EP1572962.
JD303597 - Sequence 284621 from Patent EP1572962.
JD045806 - Sequence 26830 from Patent EP1572962.
JD314876 - Sequence 295900 from Patent EP1572962.
JD084019 - Sequence 65043 from Patent EP1572962.
JD328087 - Sequence 309111 from Patent EP1572962.
JD166324 - Sequence 147348 from Patent EP1572962.
JD284967 - Sequence 265991 from Patent EP1572962.
JD311090 - Sequence 292114 from Patent EP1572962.
JD314881 - Sequence 295905 from Patent EP1572962.
JD314880 - Sequence 295904 from Patent EP1572962.
JD314873 - Sequence 295897 from Patent EP1572962.
JD314874 - Sequence 295898 from Patent EP1572962.
JD504299 - Sequence 485323 from Patent EP1572962.
JD202374 - Sequence 183398 from Patent EP1572962.
JD236769 - Sequence 217793 from Patent EP1572962.
JD530708 - Sequence 511732 from Patent EP1572962.
JD042156 - Sequence 23180 from Patent EP1572962.
JD327437 - Sequence 308461 from Patent EP1572962.
JD101578 - Sequence 82602 from Patent EP1572962.
JD049153 - Sequence 30177 from Patent EP1572962.
JD195612 - Sequence 176636 from Patent EP1572962.
JD385468 - Sequence 366492 from Patent EP1572962.
JD212529 - Sequence 193553 from Patent EP1572962.
JD197903 - Sequence 178927 from Patent EP1572962.
JD413015 - Sequence 394039 from Patent EP1572962.
JD513169 - Sequence 494193 from Patent EP1572962.
JD381252 - Sequence 362276 from Patent EP1572962.
JD421780 - Sequence 402804 from Patent EP1572962.
JD285176 - Sequence 266200 from Patent EP1572962.
JD283299 - Sequence 264323 from Patent EP1572962.
JD497064 - Sequence 478088 from Patent EP1572962.
JD275188 - Sequence 256212 from Patent EP1572962.
JD275189 - Sequence 256213 from Patent EP1572962.
JD107162 - Sequence 88186 from Patent EP1572962.
JD075733 - Sequence 56757 from Patent EP1572962.
JD210521 - Sequence 191545 from Patent EP1572962.
JD135711 - Sequence 116735 from Patent EP1572962.
JD412162 - Sequence 393186 from Patent EP1572962.
JD360561 - Sequence 341585 from Patent EP1572962.
JD037086 - Sequence 18110 from Patent EP1572962.
JD307090 - Sequence 288114 from Patent EP1572962.
JD307091 - Sequence 288115 from Patent EP1572962.
JD322970 - Sequence 303994 from Patent EP1572962.
JD401641 - Sequence 382665 from Patent EP1572962.
JD401642 - Sequence 382666 from Patent EP1572962.
JD401643 - Sequence 382667 from Patent EP1572962.
JD425084 - Sequence 406108 from Patent EP1572962.
JD309267 - Sequence 290291 from Patent EP1572962.
JD263689 - Sequence 244713 from Patent EP1572962.
JD304757 - Sequence 285781 from Patent EP1572962.
JD512474 - Sequence 493498 from Patent EP1572962.
JD097392 - Sequence 78416 from Patent EP1572962.
JD050792 - Sequence 31816 from Patent EP1572962.
JD364435 - Sequence 345459 from Patent EP1572962.
JD504722 - Sequence 485746 from Patent EP1572962.
JD366166 - Sequence 347190 from Patent EP1572962.
JD149172 - Sequence 130196 from Patent EP1572962.
JD280785 - Sequence 261809 from Patent EP1572962.
JD054246 - Sequence 35270 from Patent EP1572962.
JD309790 - Sequence 290814 from Patent EP1572962.
JD315485 - Sequence 296509 from Patent EP1572962.
JD237411 - Sequence 218435 from Patent EP1572962.
JD449361 - Sequence 430385 from Patent EP1572962.
JD237897 - Sequence 218921 from Patent EP1572962.
JD287677 - Sequence 268701 from Patent EP1572962.
JD091579 - Sequence 72603 from Patent EP1572962.
MA576113 - JP 2018138019-A/148039: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001013746, NP_057304, Q9UII5, ZFD25, ZN107_HUMAN, ZNF588
UCSC ID: uc003tte.3
RefSeq Accession: NM_001013746
Protein: Q9UII5 (aka ZN107_HUMAN)
CCDS: CCDS5527.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001013746.1
exon count: 5CDS single in 3' UTR: no RNA size: 5239
ORF size: 2352CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 4758.00frame shift in genome: no % Coverage: 99.94
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.