Human Gene MYB (uc003qfh.3) Description and Page Index
  Description: Homo sapiens v-myb myeloblastosis viral oncogene homolog (avian) (MYB), transcript variant 1, mRNA.
RefSeq Summary (NM_001130173): This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Transcript (Including UTRs)
   Position: hg19 chr6:135,502,453-135,540,311 Size: 37,859 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr6:135,502,652-135,539,118 Size: 36,467 Coding Exon Count: 16 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:135,502,453-135,540,311)mRNA (may differ from genome)Protein (761 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
HGNCHPRDLynxMGIOMIMPubMed
ReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MYB
CDC HuGE Published Literature: MYB
Positive Disease Associations: Beta thalassemia/hemoglobin E disease , hematocrit , hematological parameters , mean corpuscular hemoglobin , mean corpuscular volume , other erythrocyte phenotypes
Related Studies:
  1. Beta thalassemia/hemoglobin E disease
    Nuinoon ,et al. 2009, A genome-wide association identified the common genetic variants influence disease severity in beta(0)-thalassemia/hemoglobin E, Human genetics 2009 . [PubMed 19924444]
  2. hematocrit
    Ganesh ,et al. 2009, Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium, Nature genetics 2009 41- 11 : 1191-8. [PubMed 19862010]
  3. hematological parameters
    Soranzo ,et al. 2009, A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium, Nature genetics 2009 41- 11 : 1182-90. [PubMed 19820697]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: MYB
Diseases sorted by gene-association score: angiocentric glioma* (260), acute basophilic leukemia* (247), precursor t-cell acute lymphoblastic leukemia* (106), leukemia, acute lymphoblastic* (30), tuberculous salpingitis (15), malignant histiocytosis (12), trachea adenoid cystic carcinoma (10), gallbladder adenocarcinoma (10), tracheal cancer (7), bone ewing's sarcoma (6), myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency (5), polymorphous low-grade adenocarcinoma (5), leukemia, chronic myeloid, somatic (2), leukemia, acute myeloid (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.02 RPKM in Colon - Transverse
Total median expression: 34.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -95.40199-0.479 Picture PostScript Text
3' UTR -294.601193-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00249 - Myb-like DNA-binding domain
PF07988 - LMSTEN motif
PF09316 - C-myb, C-terminal
PF13921 - Myb-like DNA-binding domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P10242-4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AJ606317 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 8A.
AJ606318 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 9Ai.
AJ606319 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 9Aii.
AJ606320 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 8.
AJ606321 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 8B.
AJ606322 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 10A.
AJ606323 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 13A.
AJ606324 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 14A.
FW340095 - Screening.
X52125 - Human alternatively spliced c-myb mRNA (clone=pMbm-1).
BC064955 - Homo sapiens v-myb myeloblastosis viral oncogene homolog (avian), mRNA (cDNA clone MGC:70781 IMAGE:6069320), complete cds.
AJ616235 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene).
M15024 - Human c-myb mRNA, complete cds.
AF104863 - Homo sapiens MYB proto-oncogene protein (MYB) mRNA, complete cds.
AB527731 - Synthetic construct DNA, clone: pF1KB6253, Homo sapiens MYB gene for v-myb myeloblastosis viral oncogene homolog, without stop codon, in Flexi system.
KJ891658 - Synthetic construct Homo sapiens clone ccsbBroadEn_01052 MYB gene, encodes complete protein.
AY787443 - Homo sapiens isolate DelE13 c-myb-like mRNA, complete sequence.
AY787444 - Homo sapiens isolate DelE3E5 c-myb-like mRNA, complete sequence.
AY787445 - Homo sapiens isolate DelE3E8A c-myb-like mRNA, complete sequence.
AY787446 - Homo sapiens isolate DelE5E8A c-myb-like mRNA, complete sequence.
AY787447 - Homo sapiens isolate DelE8 c-myb-like mRNA, complete sequence.
AY787448 - Homo sapiens isolate DelE9 c-myb-like mRNA, complete sequence.
AY787452 - Homo sapiens isolate E12L-2 c-myb-like mRNA, complete sequence.
AY787453 - Homo sapiens isolate E13A c-myb-like mRNA, complete sequence.
AY787454 - Homo sapiens isolate E8A c-myb-like mRNA, complete sequence.
AY787455 - Homo sapiens isolate E8A2E9B c-myb-like mRNA, complete sequence.
AY787459 - Homo sapiens isolate E8SE8A c-myb-like mRNA, complete sequence.
AY787460 - Homo sapiens isolate E8SE8AE9B c-myb-like mRNA, complete sequence.
AY787461 - Homo sapiens isolate E8SE9B c-myb-like mRNA, complete sequence.
AY787462 - Homo sapiens isolate E8SE9S-85E9AB c-myb-like mRNA, complete sequence.
AY787463 - Homo sapiens isolate E8SE9S-85E9B c-myb-like mRNA, complete sequence.
AY787464 - Homo sapiens isolate E9A c-myb-like mRNA, complete sequence.
AY787465 - Homo sapiens isolate E9AB c-myb-like mRNA, complete sequence.
AY787467 - Homo sapiens isolate E9B c-myb-like mRNA, complete sequence.
AY787468 - Homo sapiens isolate E9S-48E9B c-myb-like mRNA, complete sequence.
AY787470 - Homo sapiens isolate E9S-85 c-myb-like mRNA, complete sequence.
AY787472 - Homo sapiens isolate E9S-85E9A c-myb-like mRNA, complete sequence.
AY787473 - Homo sapiens isolate E9S-85E9AB c-myb-like mRNA, complete sequence.
AY787474 - Homo sapiens isolate E9S-85E9B c-myb-like mRNA, complete sequence.
AY787475 - Homo sapiens isolate M15024 c-myb-like mRNA, complete sequence.
AY787451 - Homo sapiens isolate E12L-1 c-myb-like mRNA, complete sequence.
AY787449 - Homo sapiens isolate DelE9E10A c-myb-like mRNA, complete sequence.
AY787450 - Homo sapiens isolate E10A c-myb-like mRNA, complete sequence.
AY787456 - Homo sapiens isolate E8AE10A.txt c-myb-like mRNA, complete sequence.
AY787457 - Homo sapiens isolate E8AE9S-85E10A c-myb-like mRNA, complete sequence.
AY787458 - Homo sapiens isolate E8SE10A c-myb-like mRNA, complete sequence.
AY787466 - Homo sapiens isolate E9AE10A c-myb-like mRNA, complete sequence.
AY787469 - Homo sapiens isolate E9S-48E9BE10A c-myb-like mRNA, complete sequence.
AY787471 - Homo sapiens isolate E9S-85E10A c-myb-like mRNA, complete sequence.
X52126 - Human alternatively spliced c-myb mRNA (clone=pMbm-2).
M13665 - Human c-myb mRNA, 3'end.
BC035996 - Homo sapiens, Similar to v-myb myeloblastosis viral oncogene homolog (avian), clone IMAGE:4686589, mRNA.
AJ616791 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 1 and joined CDS.
JD445418 - Sequence 426442 from Patent EP1572962.
JD173383 - Sequence 154407 from Patent EP1572962.
JD057050 - Sequence 38074 from Patent EP1572962.
AJ616792 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 2.
M13666 - Human c-myb mRNA, 3' end.
AJ616793 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 3.
AJ616794 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 4.
FJ969915 - Homo sapiens MYB/NFIB fusion protein variant 1 (MYB/NFIB fusion) mRNA, partial cds.
FJ969916 - Homo sapiens MYB/NFIB fusion protein variant 2 (MYB/NFIB fusion) mRNA, partial cds.
FJ969917 - Homo sapiens MYB/NFIB fusion protein variant 3 (MYB/NFIB fusion) mRNA, partial cds.
AJ616795 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 5.
AJ616796 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 6.
AJ616797 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 7.
AJ616798 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 8.
AJ616799 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 9.
X17469 - Human mRNA for c-myb gene exon 9A.
AJ616800 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 10.
AJ616801 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 11.
AJ616802 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 12.
CQ873766 - Sequence 185 from Patent WO2004076622.
DD413603 - Regulation of Mammalian Cells.
AJ616803 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 13.
AJ616804 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 14.
AJ616805 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 15.
JD545763 - Sequence 526787 from Patent EP1572962.
JD333991 - Sequence 315015 from Patent EP1572962.
FW573307 - JP 2010529847-A/28: Oligonucleotides for modulation of target RNA activity.
HI463868 - Sequence 13 from Patent EP2124967.
JD557793 - Sequence 538817 from Patent EP1572962.
CQ873705 - Sequence 124 from Patent WO2004076622.
DD413542 - Regulation of Mammalian Cells.
HI463869 - Sequence 14 from Patent EP2124967.
HI463870 - Sequence 15 from Patent EP2124967.
FW573305 - JP 2010529847-A/26: Oligonucleotides for modulation of target RNA activity.
FW573306 - JP 2010529847-A/27: Oligonucleotides for modulation of target RNA activity.
HI463871 - Sequence 16 from Patent EP2124967.
HI463872 - Sequence 17 from Patent EP2124967.
FW573308 - JP 2010529847-A/29: Oligonucleotides for modulation of target RNA activity.
HI463873 - Sequence 18 from Patent EP2124967.
HI463874 - Sequence 19 from Patent EP2124967.
HI463875 - Sequence 20 from Patent EP2124967.
JD232050 - Sequence 213074 from Patent EP1572962.
HI463876 - Sequence 21 from Patent EP2124967.
HI463877 - Sequence 22 from Patent EP2124967.
JD182305 - Sequence 163329 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P10242 (Reactome details) participates in the following event(s):

R-HSA-992696 p53, SIN3A and MYB form a complex
R-HSA-8956586 RUNX1-containing TAL1 complex binds the MYB gene enhancer
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-109582 Hemostasis
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939211 ESR-mediated signaling
R-HSA-212436 Generic Transcription Pathway
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-162582 Signal Transduction
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001130173, NP_001123645, P10242-4
UCSC ID: uc003qfh.3
RefSeq Accession: NM_001130173
Protein: P10242-4, splice isoform of P10242 CCDS: CCDS47481.1, CCDS55058.1, CCDS55059.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001130173.1
exon count: 16CDS single in 3' UTR: no RNA size: 3681
ORF size: 2286CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4749.00frame shift in genome: no % Coverage: 99.92
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.