Human Gene CENPK (uc003jtu.3) Description and Page Index
Description: Homo sapiens centromere protein K (CENPK), transcript variant 2, mRNA. RefSeq Summary (NM_001267038): CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr5:64,813,593-64,858,995 Size: 45,403 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr5:64,814,302-64,850,734 Size: 36,433 Coding Exon Count: 9
ID:CENPK_HUMAN DESCRIPTION: RecName: Full=Centromere protein K; Short=CENP-K; AltName: Full=Interphase centromere complex protein 37; AltName: Full=Protein AF-5alpha; AltName: Full=p33; FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore. SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interacts directly with CENPH. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. TISSUE SPECIFICITY: Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta. DISEASE: Note=Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with MLL. SIMILARITY: Belongs to the CENPK family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11802 - Centromere-associated protein K
ModBase Predicted Comparative 3D Structure on Q9BS16
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.