Human Gene PDCD1 (uc002wcq.4) Description and Page Index
  Description: Homo sapiens programmed cell death 1 (PDCD1), mRNA.
RefSeq Summary (NM_005018): This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U64863.1, SRR1163657.360434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000334409.10/ ENSP00000335062.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr2:242,792,033-242,801,058 Size: 9,026 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr2:242,793,210-242,800,990 Size: 7,781 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:242,792,033-242,801,058)mRNA (may differ from genome)Protein (288 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: PDCD1_HUMAN
DESCRIPTION: RecName: Full=Programmed cell death protein 1; Short=Protein PD-1; Short=hPD-1; AltName: CD_antigen=CD279; Flags: Precursor;
FUNCTION: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors.
SUBUNIT: Monomer (By similarity).
INTERACTION: Q9NZQ7:CD274; NbExp=2; IntAct=EBI-4314328, EBI-4314282;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DEVELOPMENTAL STAGE: Induced at programmed cell death.
DISEASE: Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PDCD1
CDC HuGE Published Literature: PDCD1
Positive Disease Associations: ankylosing spondylitis , diabetes, type 1 , Graves' disease , Lupus , lupus erythematosus , Lupus Erythematosus, Systemic , lupus erythematosus; rheumatoid arthritis , Lupus Nephritis , multiple sclerosis , rheumatoid arthritis , systemic lupus erythematosus
Related Studies:
  1. ankylosing spondylitis
    Lee, S. H. et al. 2006, Association of the programmed cell death 1 (PDCD1) gene polymorphism with ankylosing spondylitis in the Korean population, Arthritis Res Ther 2006 8(6) R163. [PubMed 17064404]
  2. ankylosing spondylitis
    Xiang Liu , et al. Rheumatology international 2009 Dec, Programmed cell death 1 gene polymorphisms is associated with ankylosing spondylitis in Chinese Han population., Rheumatology international 2009 Dec. [PubMed 20012629]
  3. diabetes, type 1
    Nielsen, C. et al. 2003, Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes., Tissue antigens. 2003 Dec;62(6):492-7. [PubMed 14617032]
    The associated allele is previously shown to alter a transcription factor-binding site (RUNX1/AML1), and the results of this study suggest that this allele could act as an additional susceptibility allele to type 1 diabetes.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: PDCD1
Diseases sorted by gene-association score: systemic lupus erythematosus 2* (569), multiple sclerosis, disease progression, modifier of* (321), systemic lupus erythematosus (19), nodular lymphocyte predominant hodgkin lymphoma (13), lupus erythematosus (11), myasthenic syndrome, congenital, 7, presynaptic (9), autoimmune hepatitis (8), lymphoepithelioma-like carcinoma (7), progressive multifocal leukoencephalopathy (5), dilated cardiomyopathy (3), aplastic anemia (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.09 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 38.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.5068-0.331 Picture PostScript Text
3' UTR -574.811177-0.488 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013106 - Ig_V-set
IPR003596 - Ig_V-set_subgr

Pfam Domains:
PF00047 - Immunoglobulin domain
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3RRQ
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q15116
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding

Biological Process:
GO:0002376 immune system process
GO:0002644 negative regulation of tolerance induction
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0031295 T cell costimulation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0070234 positive regulation of T cell apoptotic process

Cellular Component:
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LQ882886 - Sequence 35 from Patent WO2018160841.
U64863 - Human hPD-1 (hPD-1) mRNA, complete cds.
JD480192 - Sequence 461216 from Patent EP1572962.
JD114697 - Sequence 95721 from Patent EP1572962.
JD251209 - Sequence 232233 from Patent EP1572962.
JD085426 - Sequence 66450 from Patent EP1572962.
JD288881 - Sequence 269905 from Patent EP1572962.
JD190262 - Sequence 171286 from Patent EP1572962.
JD504635 - Sequence 485659 from Patent EP1572962.
JD403628 - Sequence 384652 from Patent EP1572962.
JD434415 - Sequence 415439 from Patent EP1572962.
JD108595 - Sequence 89619 from Patent EP1572962.
JD499460 - Sequence 480484 from Patent EP1572962.
JD203539 - Sequence 184563 from Patent EP1572962.
JD530470 - Sequence 511494 from Patent EP1572962.
JD424093 - Sequence 405117 from Patent EP1572962.
JD200792 - Sequence 181816 from Patent EP1572962.
JD538420 - Sequence 519444 from Patent EP1572962.
AY322430 - Homo sapiens PD1 splice variant mRNA, complete cds, alternatively spliced.
JD115087 - Sequence 96111 from Patent EP1572962.
JD485042 - Sequence 466066 from Patent EP1572962.
JD408891 - Sequence 389915 from Patent EP1572962.
JD056415 - Sequence 37439 from Patent EP1572962.
JD106773 - Sequence 87797 from Patent EP1572962.
JD131803 - Sequence 112827 from Patent EP1572962.
JD186153 - Sequence 167177 from Patent EP1572962.
BC074740 - Homo sapiens programmed cell death 1, mRNA (cDNA clone MGC:103817 IMAGE:30915198), complete cds.
E10224 - cDNA encoding a peptide related to apoptosis(human PD-1).
AY238517 - Homo sapiens programmed cell death 1 (PDCD1) mRNA, complete cds.
KJ865859 - Homo sapiens cell-line A375 programmed cell death 1 protein (PDCD1) mRNA, complete cds.
KJ865860 - Homo sapiens cell-line C8161 programmed cell death 1 protein (PDCD1) mRNA, complete cds.
KJ865861 - Homo sapiens cell-line G3361 programmed cell death 1 protein (PDCD1) mRNA, complete cds.
AK313848 - Homo sapiens cDNA, FLJ94476, highly similar to Homo sapiens programmed cell death 1 (PDCD1), mRNA.
KJ897305 - Synthetic construct Homo sapiens clone ccsbBroadEn_06699 PDCD1 gene, encodes complete protein.
E10223 - cDNA encoding a peptide related to apoptosis(human PD-1).
AB590949 - Synthetic construct DNA, clone: pFN21AE1780, Homo sapiens PDCD1 gene for programmed cell death 1, without stop codon, in Flexi system.
AY206416 - Homo sapiens programmed cell death 1 mRNA, partial cds; alternatively spliced.
JD076396 - Sequence 57420 from Patent EP1572962.
JD170410 - Sequence 151434 from Patent EP1572962.
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MA873975 - JP 2018536436-A/5811: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA873970 - JP 2018536436-A/5806: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872600 - JP 2018536436-A/4436: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872603 - JP 2018536436-A/4439: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA873960 - JP 2018536436-A/5796: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872675 - JP 2018536436-A/4511: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA873953 - JP 2018536436-A/5789: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872680 - JP 2018536436-A/4516: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872681 - JP 2018536436-A/4517: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873951 - JP 2018536436-A/5787: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA873943 - JP 2018536436-A/5779: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872686 - JP 2018536436-A/4522: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873942 - JP 2018536436-A/5778: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872687 - JP 2018536436-A/4523: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873939 - JP 2018536436-A/5775: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872688 - JP 2018536436-A/4524: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872689 - JP 2018536436-A/4525: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872690 - JP 2018536436-A/4526: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA873931 - JP 2018536436-A/5767: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA873930 - JP 2018536436-A/5766: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872699 - JP 2018536436-A/4535: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872700 - JP 2018536436-A/4536: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872702 - JP 2018536436-A/4538: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872703 - JP 2018536436-A/4539: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872704 - JP 2018536436-A/4540: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872705 - JP 2018536436-A/4541: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872706 - JP 2018536436-A/4542: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872729 - JP 2018536436-A/4565: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872730 - JP 2018536436-A/4566: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872731 - JP 2018536436-A/4567: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872732 - JP 2018536436-A/4568: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872733 - JP 2018536436-A/4569: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872734 - JP 2018536436-A/4570: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872735 - JP 2018536436-A/4571: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872736 - JP 2018536436-A/4572: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873901 - JP 2018536436-A/5737: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872737 - JP 2018536436-A/4573: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873900 - JP 2018536436-A/5736: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872738 - JP 2018536436-A/4574: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873899 - JP 2018536436-A/5735: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872739 - JP 2018536436-A/4575: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA872740 - JP 2018536436-A/4576: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873895 - JP 2018536436-A/5731: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA873893 - JP 2018536436-A/5729: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA874786 - JP 2018536436-A/6622: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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MA873892 - JP 2018536436-A/5728: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872747 - JP 2018536436-A/4583: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873891 - JP 2018536436-A/5727: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872748 - JP 2018536436-A/4584: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873890 - JP 2018536436-A/5726: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872749 - JP 2018536436-A/4585: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873889 - JP 2018536436-A/5725: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872750 - JP 2018536436-A/4586: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872751 - JP 2018536436-A/4587: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872752 - JP 2018536436-A/4588: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA873887 - JP 2018536436-A/5723: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA872753 - JP 2018536436-A/4589: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594808 - KR 1020180133840-A/4232: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY594853 - KR 1020180133840-A/4277: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594854 - KR 1020180133840-A/4278: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594855 - KR 1020180133840-A/4279: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594856 - KR 1020180133840-A/4280: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594857 - KR 1020180133840-A/4281: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594858 - KR 1020180133840-A/4282: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY594865 - KR 1020180133840-A/4289: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594866 - KR 1020180133840-A/4290: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY594888 - KR 1020180133840-A/4312: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY594898 - KR 1020180133840-A/4322: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594899 - KR 1020180133840-A/4323: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY594901 - KR 1020180133840-A/4325: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594902 - KR 1020180133840-A/4326: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594903 - KR 1020180133840-A/4327: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594904 - KR 1020180133840-A/4328: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594905 - KR 1020180133840-A/4329: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594906 - KR 1020180133840-A/4330: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594907 - KR 1020180133840-A/4331: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594908 - KR 1020180133840-A/4332: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594909 - KR 1020180133840-A/4333: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY594911 - KR 1020180133840-A/4335: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594912 - KR 1020180133840-A/4336: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594913 - KR 1020180133840-A/4337: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594914 - KR 1020180133840-A/4338: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594915 - KR 1020180133840-A/4339: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594916 - KR 1020180133840-A/4340: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594917 - KR 1020180133840-A/4341: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594918 - KR 1020180133840-A/4342: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594919 - KR 1020180133840-A/4343: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594920 - KR 1020180133840-A/4344: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594921 - KR 1020180133840-A/4345: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594922 - KR 1020180133840-A/4346: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594923 - KR 1020180133840-A/4347: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594929 - KR 1020180133840-A/4353: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594930 - KR 1020180133840-A/4354: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594931 - KR 1020180133840-A/4355: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594932 - KR 1020180133840-A/4356: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594933 - KR 1020180133840-A/4357: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594934 - KR 1020180133840-A/4358: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594935 - KR 1020180133840-A/4359: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594936 - KR 1020180133840-A/4360: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594937 - KR 1020180133840-A/4361: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594938 - KR 1020180133840-A/4362: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594939 - KR 1020180133840-A/4363: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594940 - KR 1020180133840-A/4364: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594941 - KR 1020180133840-A/4365: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594942 - KR 1020180133840-A/4366: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594943 - KR 1020180133840-A/4367: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594944 - KR 1020180133840-A/4368: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594945 - KR 1020180133840-A/4369: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594946 - KR 1020180133840-A/4370: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594947 - KR 1020180133840-A/4371: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594948 - KR 1020180133840-A/4372: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594949 - KR 1020180133840-A/4373: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594950 - KR 1020180133840-A/4374: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594951 - KR 1020180133840-A/4375: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594952 - KR 1020180133840-A/4376: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594953 - KR 1020180133840-A/4377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594954 - KR 1020180133840-A/4378: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594955 - KR 1020180133840-A/4379: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594956 - KR 1020180133840-A/4380: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594957 - KR 1020180133840-A/4381: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594958 - KR 1020180133840-A/4382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594959 - KR 1020180133840-A/4383: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594960 - KR 1020180133840-A/4384: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594961 - KR 1020180133840-A/4385: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594962 - KR 1020180133840-A/4386: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594963 - KR 1020180133840-A/4387: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594964 - KR 1020180133840-A/4388: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594965 - KR 1020180133840-A/4389: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594966 - KR 1020180133840-A/4390: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594967 - KR 1020180133840-A/4391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594968 - KR 1020180133840-A/4392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594969 - KR 1020180133840-A/4393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594970 - KR 1020180133840-A/4394: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594971 - KR 1020180133840-A/4395: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594972 - KR 1020180133840-A/4396: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594973 - KR 1020180133840-A/4397: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594974 - KR 1020180133840-A/4398: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594975 - KR 1020180133840-A/4399: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594976 - KR 1020180133840-A/4400: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594977 - KR 1020180133840-A/4401: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596387 - KR 1020180133840-A/5811: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594990 - KR 1020180133840-A/4414: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596386 - KR 1020180133840-A/5810: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY594991 - KR 1020180133840-A/4415: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595009 - KR 1020180133840-A/4433: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596382 - KR 1020180133840-A/5806: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595010 - KR 1020180133840-A/4434: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596380 - KR 1020180133840-A/5804: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595011 - KR 1020180133840-A/4435: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596379 - KR 1020180133840-A/5803: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595012 - KR 1020180133840-A/4436: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595013 - KR 1020180133840-A/4437: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595014 - KR 1020180133840-A/4438: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595015 - KR 1020180133840-A/4439: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596378 - KR 1020180133840-A/5802: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595016 - KR 1020180133840-A/4440: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596377 - KR 1020180133840-A/5801: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595017 - KR 1020180133840-A/4441: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596376 - KR 1020180133840-A/5800: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595018 - KR 1020180133840-A/4442: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596373 - KR 1020180133840-A/5797: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595019 - KR 1020180133840-A/4443: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596372 - KR 1020180133840-A/5796: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595020 - KR 1020180133840-A/4444: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596370 - KR 1020180133840-A/5794: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595021 - KR 1020180133840-A/4445: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596368 - KR 1020180133840-A/5792: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595087 - KR 1020180133840-A/4511: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595088 - KR 1020180133840-A/4512: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595089 - KR 1020180133840-A/4513: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595090 - KR 1020180133840-A/4514: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595091 - KR 1020180133840-A/4515: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596365 - KR 1020180133840-A/5789: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595092 - KR 1020180133840-A/4516: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596364 - KR 1020180133840-A/5788: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595093 - KR 1020180133840-A/4517: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596363 - KR 1020180133840-A/5787: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595094 - KR 1020180133840-A/4518: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595095 - KR 1020180133840-A/4519: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595096 - KR 1020180133840-A/4520: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595097 - KR 1020180133840-A/4521: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596355 - KR 1020180133840-A/5779: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595098 - KR 1020180133840-A/4522: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596354 - KR 1020180133840-A/5778: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595099 - KR 1020180133840-A/4523: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596351 - KR 1020180133840-A/5775: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595100 - KR 1020180133840-A/4524: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596350 - KR 1020180133840-A/5774: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595101 - KR 1020180133840-A/4525: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596348 - KR 1020180133840-A/5772: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595102 - KR 1020180133840-A/4526: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596347 - KR 1020180133840-A/5771: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595103 - KR 1020180133840-A/4527: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595104 - KR 1020180133840-A/4528: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596343 - KR 1020180133840-A/5767: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595105 - KR 1020180133840-A/4529: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596342 - KR 1020180133840-A/5766: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595106 - KR 1020180133840-A/4530: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595108 - KR 1020180133840-A/4532: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595109 - KR 1020180133840-A/4533: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595111 - KR 1020180133840-A/4535: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596326 - KR 1020180133840-A/5750: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595112 - KR 1020180133840-A/4536: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595113 - KR 1020180133840-A/4537: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596322 - KR 1020180133840-A/5746: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595114 - KR 1020180133840-A/4538: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596320 - KR 1020180133840-A/5744: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595115 - KR 1020180133840-A/4539: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596318 - KR 1020180133840-A/5742: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595116 - KR 1020180133840-A/4540: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595117 - KR 1020180133840-A/4541: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595118 - KR 1020180133840-A/4542: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595141 - KR 1020180133840-A/4565: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595142 - KR 1020180133840-A/4566: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595143 - KR 1020180133840-A/4567: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595144 - KR 1020180133840-A/4568: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595145 - KR 1020180133840-A/4569: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595146 - KR 1020180133840-A/4570: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595147 - KR 1020180133840-A/4571: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595148 - KR 1020180133840-A/4572: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596313 - KR 1020180133840-A/5737: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595149 - KR 1020180133840-A/4573: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596312 - KR 1020180133840-A/5736: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595150 - KR 1020180133840-A/4574: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596311 - KR 1020180133840-A/5735: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595151 - KR 1020180133840-A/4575: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596310 - KR 1020180133840-A/5734: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595152 - KR 1020180133840-A/4576: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596307 - KR 1020180133840-A/5731: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595153 - KR 1020180133840-A/4577: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596306 - KR 1020180133840-A/5730: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595154 - KR 1020180133840-A/4578: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596305 - KR 1020180133840-A/5729: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595155 - KR 1020180133840-A/4579: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597198 - KR 1020180133840-A/6657: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595156 - KR 1020180133840-A/4580: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595157 - KR 1020180133840-A/4581: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595158 - KR 1020180133840-A/4582: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596304 - KR 1020180133840-A/5728: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595159 - KR 1020180133840-A/4583: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596303 - KR 1020180133840-A/5727: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595160 - KR 1020180133840-A/4584: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596302 - KR 1020180133840-A/5726: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595161 - KR 1020180133840-A/4585: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596301 - KR 1020180133840-A/5725: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595162 - KR 1020180133840-A/4586: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595163 - KR 1020180133840-A/4587: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595164 - KR 1020180133840-A/4588: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596299 - KR 1020180133840-A/5723: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY595165 - KR 1020180133840-A/4589: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04514 - Cell adhesion molecules (CAMs)
hsa04660 - T cell receptor signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein Q15116 (Reactome details) participates in the following event(s):

R-HSA-388828 PD-1 binds B7DC and B7H1
R-HSA-389762 Phosphorylation of PD-1
R-HSA-389759 Interaction of SHP-1 or SHP-2 with phospho PD-1
R-HSA-389758 Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
R-HSA-389948 PD-1 signaling
R-HSA-388841 Costimulation by the CD28 family
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: NM_005018, NP_005009, O00517, PD1, PDCD1_HUMAN, Q15116, Q8IX89
UCSC ID: uc002wcq.4
RefSeq Accession: NM_005018
Protein: Q15116 (aka PDCD1_HUMAN or PCD1_HUMAN)
CCDS: CCDS33428.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_005018.2
exon count: 5CDS single in 3' UTR: no RNA size: 2115
ORF size: 867CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1599.00frame shift in genome: no % Coverage: 99.86
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.