Human Gene CCNF (uc002cqd.1) Description and Page Index
Description: Homo sapiens cyclin F (CCNF), mRNA. RefSeq Summary (NM_001761): This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z36714.1, SRR1803617.234804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000397066.9/ ENSP00000380256.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr16:2,479,395-2,508,859 Size: 29,465 Total Exon Count: 17 Strand: + Coding Region Position: hg19 chr16:2,479,483-2,507,021 Size: 27,539 Coding Exon Count: 17
ID:CCNF_HUMAN DESCRIPTION: RecName: Full=Cyclin-F; AltName: Full=F-box only protein 1; FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. SUBUNIT: Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway. INTERACTION: P31350:RRM2; NbExp=12; IntAct=EBI-1207574, EBI-2339245; P63208:SKP1; NbExp=6; IntAct=EBI-1207574, EBI-307486; SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus. TISSUE SPECIFICITY: Widely expressed. DEVELOPMENTAL STAGE: Appears in S phase, peaks in G2 phase and disappears as cells enter into mitosis (at protein level). DOMAIN: The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus. PTM: Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence. PTM: Phosphorylated just before cells enter into mitosis. MISCELLANEOUS: Founding member of the F-box domain protein family, which obtained its name from cyclin-F (PubMed:8706131). SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily. SIMILARITY: Contains 1 cyclin N-terminal domain. SIMILARITY: Contains 1 F-box domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41002
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.