Human Gene MST1 (uc003cxg.3) Description and Page Index
  Description: Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) (MST1), mRNA.
RefSeq Summary (NM_020998): The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010].
Transcript (Including UTRs)
   Position: hg19 chr3:49,721,380-49,726,196 Size: 4,817 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr3:49,721,461-49,726,124 Size: 4,664 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:49,721,380-49,726,196)mRNA (may differ from genome)Protein (725 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Hepatocyte growth factor-like protein beta chain; SubName: Full=Macrophage stimulating 1 (Hepatocyte growth factor-like), isoform CRA_b;
SIMILARITY: Belongs to the peptidase S1 family.
SIMILARITY: Contains 1 peptidase S1 domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MST1
CDC HuGE Published Literature: MST1
Positive Disease Associations: Cholangitis, Sclerosing , Colitis, Ulcerative , Crohn Disease , Crohn's disease , ulcerative colitis
Related Studies:
  1. Cholangitis, Sclerosing
    Espen Melum et al. Nature genetics 2011, Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci., Nature genetics. [PubMed 21151127]
  2. Colitis, Ulcerative
    Dermot P B McGovern et al. Nature genetics 2010, Genome-wide association identifies multiple ulcerative colitis susceptibility loci., Nature genetics. [PubMed 20228799]
  3. Crohn Disease
    Jeffrey C Barrett et al. Nature genetics 2008, Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease., Nature genetics. [PubMed 18587394]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: MST1
Diseases sorted by gene-association score: cholangitis, primary sclerosing* (15), familial renal papillary carcinoma (8), sclerosing cholangitis (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 319.42 RPKM in Liver
Total median expression: 697.75 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.6072-0.258 Picture PostScript Text
3' UTR -15.6081-0.193 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024174 - HGF_MST1
IPR000001 - Kringle
IPR013806 - Kringle-like
IPR018056 - Kringle_CS
IPR003014 - PAN-1_domain
IPR003609 - Pan_app
IPR009003 - Pept_cys/ser_Trypsin-like
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00024 - PAN domain
PF00051 - Kringle domain
PF00089 - Trypsin
PF14295 - PAN domain

SCOP Domains:
50494 - Trypsin-like serine proteases
57414 - Hairpin loop containing domain-like
57440 - Kringle-like

ModBase Predicted Comparative 3D Structure on G3XAK1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0019899 enzyme binding

Biological Process:
GO:0006508 proteolysis
GO:0007283 spermatogenesis
GO:0007566 embryo implantation
GO:0010628 positive regulation of gene expression
GO:0010758 regulation of macrophage chemotaxis
GO:0030317 flagellated sperm motility
GO:0030879 mammary gland development
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0046425 regulation of JAK-STAT cascade
GO:0060763 mammary duct terminal end bud growth
GO:0071456 cellular response to hypoxia
GO:1904036 negative regulation of epithelial cell apoptotic process

Cellular Component:
GO:0005737 cytoplasm
GO:0005773 vacuole

-  Descriptions from all associated GenBank mRNAs
  M74178 - Human hepatocyte growth factor-like protein mRNA, complete cds.
AK222893 - Homo sapiens mRNA for macrophage stimulating 1 (hepatocyte growth factor-like) variant, clone: HEP20874.
L11924 - Homo sapiens macrophage-stimulating protein (MST1) mRNA, complete cds.
BC048330 - Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like), mRNA (cDNA clone MGC:51837 IMAGE:5190966), complete cds.
KJ901583 - Synthetic construct Homo sapiens clone ccsbBroadEn_10977 MST1 gene, encodes complete protein.
KR711039 - Synthetic construct Homo sapiens clone CCSBHm_00019368 MST1 (MST1) mRNA, encodes complete protein.
AK298452 - Homo sapiens cDNA FLJ53076 complete cds, highly similar to Hepatocyte growth factor-like protein precursor.
AK298396 - Homo sapiens cDNA FLJ60766 complete cds, highly similar to Hepatocyte growth factor-like protein precursor.
AK309567 - Homo sapiens cDNA, FLJ99608.
AK294324 - Homo sapiens cDNA FLJ56324 complete cds, highly similar to Hepatocyte growth factor-like protein precursor.
AK296192 - Homo sapiens cDNA FLJ53768 complete cds, highly similar to Hepatocyte growth factor-like protein precursor.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mspPathway - Msp/Ron Receptor Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: G3XAK1, G3XAK1_HUMAN, hCG_2001992, NM_020998, NP_066278
UCSC ID: uc003cxg.3
RefSeq Accession: NM_020998
Protein: G3XAK1 CCDS: CCDS33757.2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_020998.3
exon count: 18CDS single in 3' UTR: no RNA size: 2348
ORF size: 2178CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4556.00frame shift in genome: no % Coverage: 99.28
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.