Human Gene ASGR2 (uc002ger.3) Description and Page Index
  Description: Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant H2', mRNA.
RefSeq Summary (NM_080912): This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Transcript (Including UTRs)
   Position: hg19 chr17:7,004,641-7,018,130 Size: 13,490 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr17:7,004,894-7,017,559 Size: 12,666 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:7,004,641-7,018,130)mRNA (may differ from genome)Protein (311 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Asialoglycoprotein receptor 2; Short=ASGP-R 2; Short=ASGPR 2; AltName: Full=C-type lectin domain family 4 member H2; AltName: Full=Hepatic lectin H2; Short=HL-2;
FUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
SUBUNIT: The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.
INTERACTION: Q96G23:CERS2; NbExp=3; IntAct=EBI-1172636, EBI-1057080;
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
TISSUE SPECIFICITY: Expressed exclusively in hepatic parenchymal cells.
MISCELLANEOUS: Calcium is required for ligand binding.
SIMILARITY: Contains 1 C-type lectin domain.
WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Hepatic asialoglycoprotein receptor subunit 2; URL="";

-  MalaCards Disease Associations
  MalaCards Gene Search: ASGR2
Diseases sorted by gene-association score: hepatitis b (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 232.22 RPKM in Liver
Total median expression: 259.53 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -101.91355-0.287 Picture PostScript Text
3' UTR -72.00253-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001304 - C-type_lectin
IPR016186 - C-type_lectin-like
IPR018378 - C-type_lectin_CS
IPR016187 - C-type_lectin_fold
IPR005640 - Lectin_N

Pfam Domains:
PF00059 - Lectin C-type domain
PF03954 - Hepatic lectin, N-terminal domain

SCOP Domains:
56436 - C-type lectin-like

ModBase Predicted Comparative 3D Structure on P07307
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004873 asialoglycoprotein receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding

Biological Process:
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0009100 glycoprotein metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030282 bone mineralization
GO:0031647 regulation of protein stability
GO:0055088 lipid homeostasis

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0044322 endoplasmic reticulum quality control compartment
GO:0048471 perinuclear region of cytoplasm

-  Descriptions from all associated GenBank mRNAs
  M11025 - Human asialoglycoprotein receptor H2 mRNA, complete cds.
LF384759 - JP 2014500723-A/192262: Polycomb-Associated Non-Coding RNAs.
BC017251 - Homo sapiens asialoglycoprotein receptor 2, mRNA (cDNA clone MGC:29619 IMAGE:5087419), complete cds.
X55284 - Human H2' mRNA coding for an asialoglycoprotein receptor.
X55283 - Human L-H2 mRNA coding for an asialoglycoprotein receptor.
JD509235 - Sequence 490259 from Patent EP1572962.
JD038939 - Sequence 19963 from Patent EP1572962.
JD278636 - Sequence 259660 from Patent EP1572962.
JD303438 - Sequence 284462 from Patent EP1572962.
JD359505 - Sequence 340529 from Patent EP1572962.
AF529374 - Homo sapiens HBxAg-binding protein (HBXBP) mRNA, complete cds.
U97197 - Homo sapiens asialoglycoprotein receptor (ASGPR) mRNA, complete cds.
KJ890716 - Synthetic construct Homo sapiens clone ccsbBroadEn_00110 ASGR2 gene, encodes complete protein.
DQ892652 - Synthetic construct clone IMAGE:100005282; FLH188670.01X; RZPDo839E1073D asialoglycoprotein receptor 2 (ASGR2) gene, encodes complete protein.
DQ895891 - Synthetic construct Homo sapiens clone IMAGE:100010351; FLH188666.01L; RZPDo839E1063D asialoglycoprotein receptor 2 (ASGR2) gene, encodes complete protein.
AB528625 - Synthetic construct DNA, clone: pF1KB6427, Homo sapiens ASGR2 gene for asialoglycoprotein receptor 2, without stop codon, in Flexi system.
CU677885 - Synthetic construct Homo sapiens gateway clone IMAGE:100018074 5' read ASGR2 mRNA.
LF326488 - JP 2014500723-A/133991: Polycomb-Associated Non-Coding RNAs.
LF326487 - JP 2014500723-A/133990: Polycomb-Associated Non-Coding RNAs.
AK310123 - Homo sapiens cDNA, FLJ17165.
AK303787 - Homo sapiens cDNA FLJ60040 complete cds, highly similar to Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant 2, mRNA.
JD337957 - Sequence 318981 from Patent EP1572962.
JD371454 - Sequence 352478 from Patent EP1572962.
JD387367 - Sequence 368391 from Patent EP1572962.
JD306763 - Sequence 287787 from Patent EP1572962.
JD100134 - Sequence 81158 from Patent EP1572962.
JD525965 - Sequence 506989 from Patent EP1572962.
JD495969 - Sequence 476993 from Patent EP1572962.
JD150580 - Sequence 131604 from Patent EP1572962.
JD149016 - Sequence 130040 from Patent EP1572962.
JD335895 - Sequence 316919 from Patent EP1572962.
MA620336 - JP 2018138019-A/192262: Polycomb-Associated Non-Coding RNAs.
MA562065 - JP 2018138019-A/133991: Polycomb-Associated Non-Coding RNAs.
MA562064 - JP 2018138019-A/133990: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P07307 (Reactome details) participates in the following event(s):

R-HSA-8855711 PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A6NLV8, A8MT12, ASGR2_HUMAN, CLEC4H2, D3DTM9, D3DTN0, NM_080912, NP_550434, O00448, P07307, Q03969
UCSC ID: uc002ger.3
RefSeq Accession: NM_080912
Protein: P07307 (aka ASGR2_HUMAN or LECI_HUMAN)
CCDS: CCDS32544.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_080912.3
exon count: 9CDS single in 3' UTR: no RNA size: 1544
ORF size: 936CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 1582.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.