Human Gene ASGR2 (uc002ger.3) Description and Page Index
Description: Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant H2', mRNA. RefSeq Summary (NM_080912): This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]. Transcript (Including UTRs) Position: hg19 chr17:7,004,641-7,018,130 Size: 13,490 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr17:7,004,894-7,017,559 Size: 12,666 Coding Exon Count: 8
ID:ASGR2_HUMAN DESCRIPTION: RecName: Full=Asialoglycoprotein receptor 2; Short=ASGP-R 2; Short=ASGPR 2; AltName: Full=C-type lectin domain family 4 member H2; AltName: Full=Hepatic lectin H2; Short=HL-2; FUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. SUBUNIT: The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2. INTERACTION: Q96G23:CERS2; NbExp=3; IntAct=EBI-1172636, EBI-1057080; SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Expressed exclusively in hepatic parenchymal cells. MISCELLANEOUS: Calcium is required for ligand binding. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Hepatic asialoglycoprotein receptor subunit 2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_216";
MalaCards Disease Associations
MalaCards Gene Search: ASGR2 Diseases sorted by gene-association score: hepatitis b (5)
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07307
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.