ID:UBE2F_HUMAN DESCRIPTION: RecName: Full=NEDD8-conjugating enzyme UBE2F; EC=6.3.2.-; AltName: Full=NEDD8 carrier protein UBE2F; AltName: Full=NEDD8 protein ligase UBE2F; AltName: Full=NEDD8-conjugating enzyme 2; AltName: Full=Ubiquitin-conjugating enzyme E2 F; FUNCTION: Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. CATALYTIC ACTIVITY: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine. PATHWAY: Protein modification; protein neddylation. SUBUNIT: Interacts with UBA3 and RBX2. TISSUE SPECIFICITY: Widely expressed (at protein level). SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q969M7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.