Human Gene METTL2B (uc003vnf.3) Description and Page Index
  Description: Homo sapiens methyltransferase like 2B (METTL2B), mRNA.
RefSeq Summary (NM_018396): This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC064929.1, SRR1803616.147591.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr7:128,116,783-128,142,978 Size: 26,196 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr7:128,116,820-128,141,970 Size: 25,151 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:128,116,783-128,142,978)mRNA (may differ from genome)Protein (378 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Methyltransferase-like protein 2B; EC=2.1.1.-;
FUNCTION: Probable methyltransferase (By similarity).
SIMILARITY: Belongs to the methyltransferase superfamily. METL family.

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.45 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 150.79 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.8037-0.184 Picture PostScript Text
3' UTR -304.441008-0.302 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026113 - MeTrfase
IPR017280 - MeTrfase_METTL2_prd

Pfam Domains:
PF01209 - ubiE/COQ5 methyltransferase family
PF08241 - Methyltransferase domain
PF08242 - Methyltransferase domain
PF13489 - Methyltransferase domain
PF13649 - Methyltransferase domain
PF13847 - Methyltransferase domain

SCOP Domains:
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q6P1Q9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008168 methyltransferase activity
GO:0016427 tRNA (cytosine) methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0030488 tRNA methylation
GO:0032259 methylation

-  Descriptions from all associated GenBank mRNAs
  AK302775 - Homo sapiens cDNA FLJ56321 complete cds, highly similar to Methyltransferase-like protein 2 (EC 2.1.1.-).
BC107586 - Homo sapiens methyltransferase like 2B, mRNA (cDNA clone MGC:104351 IMAGE:6494734), complete cds.
AK002212 - Homo sapiens cDNA FLJ11350 fis, clone Y79AA1001647.
BC064929 - Homo sapiens methyltransferase like 2B, mRNA (cDNA clone IMAGE:6143276), partial cds.
JD395177 - Sequence 376201 from Patent EP1572962.
JD395176 - Sequence 376200 from Patent EP1572962.
JD229410 - Sequence 210434 from Patent EP1572962.
BC121115 - Homo sapiens methyltransferase like 2B, mRNA (cDNA clone IMAGE:40120440), partial cds.
BC121116 - Homo sapiens methyltransferase like 2B, mRNA (cDNA clone IMAGE:40120441), partial cds.
AK299960 - Homo sapiens cDNA FLJ60870 complete cds, highly similar to Methyltransferase-like protein 2 (EC 2.1.1.-).
JD139370 - Sequence 120394 from Patent EP1572962.
JD332144 - Sequence 313168 from Patent EP1572962.
AK125539 - Homo sapiens cDNA FLJ43551 fis, clone PROST2017700.
AY358237 - Homo sapiens clone DNA143510 PSVL6168 (UNQ6168) mRNA, complete cds.
JD364809 - Sequence 345833 from Patent EP1572962.
JD483579 - Sequence 464603 from Patent EP1572962.
JD546275 - Sequence 527299 from Patent EP1572962.
JD221877 - Sequence 202901 from Patent EP1572962.
JD455061 - Sequence 436085 from Patent EP1572962.
JD537302 - Sequence 518326 from Patent EP1572962.
JD194649 - Sequence 175673 from Patent EP1572962.
JD135702 - Sequence 116726 from Patent EP1572962.
JD238287 - Sequence 219311 from Patent EP1572962.
JD101482 - Sequence 82506 from Patent EP1572962.
JD324482 - Sequence 305506 from Patent EP1572962.
JD179170 - Sequence 160194 from Patent EP1572962.
JD120114 - Sequence 101138 from Patent EP1572962.
JD113739 - Sequence 94763 from Patent EP1572962.
JD091850 - Sequence 72874 from Patent EP1572962.
JD335393 - Sequence 316417 from Patent EP1572962.
JD373371 - Sequence 354395 from Patent EP1572962.
JD180545 - Sequence 161569 from Patent EP1572962.
JD517426 - Sequence 498450 from Patent EP1572962.
JD116858 - Sequence 97882 from Patent EP1572962.
JD359313 - Sequence 340337 from Patent EP1572962.
JD564835 - Sequence 545859 from Patent EP1572962.
JD194621 - Sequence 175645 from Patent EP1572962.
JD194622 - Sequence 175646 from Patent EP1572962.
JD076278 - Sequence 57302 from Patent EP1572962.
JD194623 - Sequence 175647 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00340 - Histidine metabolism
hsa00350 - Tyrosine metabolism
hsa00450 - Selenoamino acid metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B4DZ68, MET2B_HUMAN, NM_018396, NP_060866, Q0IJ54, Q3B7J1, Q6P1Q9
UCSC ID: uc003vnf.3
RefSeq Accession: NM_018396
Protein: Q6P1Q9 (aka MET2B_HUMAN)
CCDS: CCDS5803.2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_018396.2
exon count: 9CDS single in 3' UTR: no RNA size: 2192
ORF size: 1137CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2474.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.