Human Gene C7orf60 (uc003vgo.1) Description and Page Index
  Description: Homo sapiens chromosome 7 open reading frame 60 (C7orf60), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:112,459,202-112,579,932 Size: 120,731 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr7:112,461,799-112,579,805 Size: 118,007 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:112,459,202-112,579,932)mRNA (may differ from genome)Protein (405 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CG060_HUMAN
DESCRIPTION: RecName: Full=UPF0532 protein C7orf60;
SIMILARITY: Belongs to the UPF0532 family.
SEQUENCE CAUTION: Sequence=BAB71169.1; Type=Frameshift; Positions=259;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C7orf60
CDC HuGE Published Literature: C7orf60
Positive Disease Associations: Attention Deficit and Disruptive Behavior Disorders , Hemoglobins , Monocytes
Related Studies:
  1. Attention Deficit and Disruptive Behavior Disorders
    Richard J L Anney et al. American journal of medical genetics. Part B, Neuropsychiatric genetics 2008, Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetic. [PubMed 18951430]
  2. Hemoglobins
    , , . [PubMed 0]
  3. Monocytes
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.97 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 154.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.30127-0.530 Picture PostScript Text
3' UTR -614.092597-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021867 - DUF3321

Pfam Domains:
PF11968 - 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2

ModBase Predicted Comparative 3D Structure on Q1RMZ1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008168 methyltransferase activity
GO:0016433 rRNA (adenine) methyltransferase activity
GO:0016740 transferase activity
GO:1904047 S-adenosyl-L-methionine binding

Biological Process:
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0034198 cellular response to amino acid starvation
GO:1904262 negative regulation of TORC1 signaling

Cellular Component:
GO:0005730 nucleolus
GO:1990130 Iml1 complex


-  Descriptions from all associated GenBank mRNAs
  AL834437 - Homo sapiens mRNA; cDNA DKFZp762M126 (from clone DKFZp762M126).
AF274937 - Homo sapiens PNAS-12 mRNA, partial sequence.
AK056380 - Homo sapiens cDNA FLJ31818 fis, clone NT2RP6000017.
JD288250 - Sequence 269274 from Patent EP1572962.
JD321663 - Sequence 302687 from Patent EP1572962.
JD305356 - Sequence 286380 from Patent EP1572962.
JD503145 - Sequence 484169 from Patent EP1572962.
JD185815 - Sequence 166839 from Patent EP1572962.
JD092193 - Sequence 73217 from Patent EP1572962.
JD300183 - Sequence 281207 from Patent EP1572962.
JD082192 - Sequence 63216 from Patent EP1572962.
AK299901 - Homo sapiens cDNA FLJ51698 complete cds.
BC114615 - Homo sapiens chromosome 7 open reading frame 60, mRNA (cDNA clone MGC:133225 IMAGE:40032372), complete cds.
KJ895688 - Synthetic construct Homo sapiens clone ccsbBroadEn_05082 C7orf60 gene, encodes complete protein.
JD371625 - Sequence 352649 from Patent EP1572962.
JD265577 - Sequence 246601 from Patent EP1572962.
JD436595 - Sequence 417619 from Patent EP1572962.
JD087368 - Sequence 68392 from Patent EP1572962.
JD139346 - Sequence 120370 from Patent EP1572962.
JD526876 - Sequence 507900 from Patent EP1572962.
JD536781 - Sequence 517805 from Patent EP1572962.
JD161708 - Sequence 142732 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CG060_HUMAN, NM_152556, NP_689769, Q1RMZ1, Q8N3D0, Q96MV7
UCSC ID: uc003vgo.1
RefSeq Accession: NM_152556
Protein: Q1RMZ1 (aka CG060_HUMAN)
CCDS: CCDS43634.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152556.2
exon count: 5CDS single in 3' UTR: no RNA size: 3969
ORF size: 1218CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2476.00frame shift in genome: no % Coverage: 99.32
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.