Human Gene GTPBP8 (uc003dzn.3) Description and Page Index
  Description: Homo sapiens GTP-binding protein 8 (putative) (GTPBP8), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:112,709,800-112,720,221 Size: 10,422 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr3:112,709,847-112,719,766 Size: 9,920 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:112,709,800-112,720,221)mRNA (may differ from genome)Protein (284 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=GTP-binding protein 8;
SIMILARITY: Belongs to the EngB family.
SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GTPBP8
CDC HuGE Published Literature: GTPBP8

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.27 RPKM in Testis
Total median expression: 103.08 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.0047-0.298 Picture PostScript Text
3' UTR -114.00455-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019987 - GTP-bd_ribosome_bio_YsxC
IPR006073 - GTP_binding_domain

Pfam Domains:
PF01926 - 50S ribosome-binding GTPase
PF02421 - Ferrous iron transport protein B
PF09439 - Signal recognition particle receptor beta subunit

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q8N3Z3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
 Protein SequenceProtein Sequence  Protein Sequence
 AlignmentAlignment  Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005525 GTP binding
GO:0046872 metal ion binding

Cellular Component:
GO:0005739 mitochondrion

-  Descriptions from all associated GenBank mRNAs
  AK289611 - Homo sapiens cDNA FLJ75962 complete cds, highly similar to Homo sapiens HSPC135 protein (HSPC135), transcript variant 2, mRNA.
AK292651 - Homo sapiens cDNA FLJ77392 complete cds, highly similar to Homo sapiens HSPC135 protein (HSPC135), transcript variant 1, mRNA.
BC037163 - Homo sapiens GTP-binding protein 8 (putative), mRNA (cDNA clone MGC:29499 IMAGE:4620206), complete cds.
BC000003 - Homo sapiens GTP-binding protein 8 (putative), mRNA (cDNA clone IMAGE:3504099), containing frame-shift errors.
AF161484 - Homo sapiens HSPC135 mRNA, complete cds.
BC010137 - Homo sapiens GTP-binding protein 8 (putative), mRNA (cDNA clone IMAGE:4123715).
KJ906133 - Synthetic construct Homo sapiens clone ccsbBroadEn_15803 GTPBP8 gene, encodes complete protein.
KJ893678 - Synthetic construct Homo sapiens clone ccsbBroadEn_03072 GTPBP8 gene, encodes complete protein.
DQ895506 - Synthetic construct Homo sapiens clone IMAGE:100009966; FLH185073.01L; RZPDo839E12145D GTP-binding protein 8 (putative) (GTPBP8) gene, encodes complete protein.
CU691454 - Synthetic construct Homo sapiens gateway clone IMAGE:100021917 5' read GTPBP8 mRNA.
DQ892307 - Synthetic construct clone IMAGE:100004937; FLH185077.01X; RZPDo839E12146D GTP-binding protein 8 (putative) (GTPBP8) gene, encodes complete protein.
AK093419 - Homo sapiens cDNA FLJ36100 fis, clone TESTI2021077.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NE99, A6NN11, A8K0P6, GTPB8_HUMAN, NM_014170, NP_054889, Q5I0Y4, Q8N3Z3
UCSC ID: uc003dzn.3
RefSeq Accession: NM_014170
Protein: Q8N3Z3 (aka GTPB8_HUMAN)
CCDS: CCDS33820.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_014170.2
exon count: 6CDS single in 3' UTR: no RNA size: 1364
ORF size: 855CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1910.00frame shift in genome: no % Coverage: 99.49
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.