Human Gene RPP14 (uc003dju.5) Description and Page Index
Description: Homo sapiens ribonuclease P/MRP 14kDa subunit (RPP14), transcript variant 2, mRNA. RefSeq Summary (NM_007042): This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]. Transcript (Including UTRs) Position: hg19 chr3:58,291,972-58,305,920 Size: 13,949 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr3:58,296,057-58,303,223 Size: 7,167 Coding Exon Count: 5
ID:RPP14_HUMAN DESCRIPTION: RecName: Full=Ribonuclease P protein subunit p14; EC=184.108.40.206; FUNCTION: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor. SUBUNIT: RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. SUBCELLULAR LOCATION: Nucleus (Potential). MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame. SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95059
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.