Human Gene RPP14 (uc003dju.5) Description and Page Index
  Description: Homo sapiens ribonuclease P/MRP 14kDa subunit (RPP14), transcript variant 2, mRNA.
RefSeq Summary (NM_007042): This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017].
Transcript (Including UTRs)
   Position: hg19 chr3:58,291,972-58,305,920 Size: 13,949 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr3:58,296,057-58,303,223 Size: 7,167 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:58,291,972-58,305,920)mRNA (may differ from genome)Protein (124 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ribonuclease P protein subunit p14; EC=;
FUNCTION: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor.
SUBUNIT: RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.
SUBCELLULAR LOCATION: Nucleus (Potential).
MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.
SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.02 RPKM in Muscle - Skeletal
Total median expression: 112.08 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.50194-0.379 Picture PostScript Text
3' UTR -822.852697-0.305 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002759 - RNase_P/MRP_subunit

Pfam Domains:
PF01900 - Rpp14/Pop5 family

ModBase Predicted Comparative 3D Structure on O95059
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  Protein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0004540 ribonuclease activity
GO:0016787 hydrolase activity

Biological Process:
GO:0001682 tRNA 5'-leader removal
GO:0008033 tRNA processing
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0030681 multimeric ribonuclease P complex

-  Descriptions from all associated GenBank mRNAs
  LF384957 - JP 2014500723-A/192460: Polycomb-Associated Non-Coding RNAs.
AF001175 - Homo sapiens ribonuclease P protein subunit p14 (Rpp14) mRNA, complete cds.
BC012017 - Homo sapiens ribonuclease P/MRP 14kDa subunit, mRNA (cDNA clone MGC:21293 IMAGE:4708724), complete cds.
BC002441 - Homo sapiens ribonuclease P/MRP 14kDa subunit, mRNA (cDNA clone MGC:1868 IMAGE:3347003), complete cds.
BC007342 - Homo sapiens ribonuclease P/MRP 14kDa subunit, mRNA (cDNA clone MGC:15309 IMAGE:3616325), complete cds.
AK311396 - Homo sapiens cDNA, FLJ18438.
AK311969 - Homo sapiens cDNA, FLJ92241, Homo sapiens ribonuclease P (14kD) (RPP14), mRNA.
LF332885 - JP 2014500723-A/140388: Polycomb-Associated Non-Coding RNAs.
JD060307 - Sequence 41331 from Patent EP1572962.
CR407611 - Homo sapiens full open reading frame cDNA clone RZPDo834A102D for gene RPP14, ribonuclease P (14kD) complete cds, without stopcodon.
JF432497 - Synthetic construct Homo sapiens clone IMAGE:100073718 ribonuclease P/MRP 14kDa subunit (RPP14) gene, encodes complete protein.
KJ893226 - Synthetic construct Homo sapiens clone ccsbBroadEn_02620 RPP14 gene, encodes complete protein.
LF332886 - JP 2014500723-A/140389: Polycomb-Associated Non-Coding RNAs.
LF332889 - JP 2014500723-A/140392: Polycomb-Associated Non-Coding RNAs.
JD420338 - Sequence 401362 from Patent EP1572962.
JD411711 - Sequence 392735 from Patent EP1572962.
JD146035 - Sequence 127059 from Patent EP1572962.
JD209524 - Sequence 190548 from Patent EP1572962.
JD372428 - Sequence 353452 from Patent EP1572962.
JD310599 - Sequence 291623 from Patent EP1572962.
LF332890 - JP 2014500723-A/140393: Polycomb-Associated Non-Coding RNAs.
JD545229 - Sequence 526253 from Patent EP1572962.
JD483731 - Sequence 464755 from Patent EP1572962.
JD102663 - Sequence 83687 from Patent EP1572962.
JD456764 - Sequence 437788 from Patent EP1572962.
JD456765 - Sequence 437789 from Patent EP1572962.
JD326980 - Sequence 308004 from Patent EP1572962.
JD314802 - Sequence 295826 from Patent EP1572962.
JD278081 - Sequence 259105 from Patent EP1572962.
JD126052 - Sequence 107076 from Patent EP1572962.
JD543293 - Sequence 524317 from Patent EP1572962.
JD478605 - Sequence 459629 from Patent EP1572962.
JD463856 - Sequence 444880 from Patent EP1572962.
JD148346 - Sequence 129370 from Patent EP1572962.
JD249915 - Sequence 230939 from Patent EP1572962.
JD249916 - Sequence 230940 from Patent EP1572962.
JD432648 - Sequence 413672 from Patent EP1572962.
JD481623 - Sequence 462647 from Patent EP1572962.
JD538118 - Sequence 519142 from Patent EP1572962.
JD431265 - Sequence 412289 from Patent EP1572962.
JD291735 - Sequence 272759 from Patent EP1572962.
JD421891 - Sequence 402915 from Patent EP1572962.
JD134289 - Sequence 115313 from Patent EP1572962.
JD421892 - Sequence 402916 from Patent EP1572962.
JD533693 - Sequence 514717 from Patent EP1572962.
JD446355 - Sequence 427379 from Patent EP1572962.
JD340525 - Sequence 321549 from Patent EP1572962.
JD286688 - Sequence 267712 from Patent EP1572962.
JD511526 - Sequence 492550 from Patent EP1572962.
DQ601132 - Homo sapiens piRNA piR-39198, complete sequence.
MA620534 - JP 2018138019-A/192460: Polycomb-Associated Non-Coding RNAs.
MA568462 - JP 2018138019-A/140388: Polycomb-Associated Non-Coding RNAs.
MA568463 - JP 2018138019-A/140389: Polycomb-Associated Non-Coding RNAs.
MA568466 - JP 2018138019-A/140392: Polycomb-Associated Non-Coding RNAs.
MA568467 - JP 2018138019-A/140393: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95059 (Reactome details) participates in the following event(s):

R-HSA-5696810 RNase P cleaves the 5' end of pre-tRNA
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-72306 tRNA processing
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: NM_007042, NP_008973, O95059, Q53X97, RPP14_HUMAN, uc003dju.4
UCSC ID: uc003dju.5
RefSeq Accession: NM_007042
Protein: O95059 (aka RPP14_HUMAN)
CCDS: CCDS2888.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_007042.4
exon count: 6CDS single in 3' UTR: no RNA size: 3266
ORF size: 375CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 950.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.