Human Gene METTL15 (uc001msh.2)
Description: Homo sapiens methyltransferase like 15 (METTL15), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr11:28,129,798-28,355,054 Size: 225,257 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr11:28,134,882-28,352,388 Size: 217,507 Coding Exon Count: 5
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MET15_HUMAN
DESCRIPTION: RecName: Full=Probable methyltransferase-like protein 15; EC=2.1.1.-; AltName: Full=Methyltransferase 5 domain-containing protein 1;
FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase (By similarity).SIMILARITY: Belongs to the methyltransferase superfamily. RsmH family.SEQUENCE CAUTION: Sequence=AAH30997.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002903 - SAM-dep_MeTrfase_MraW
IPR023397 - SAM-dep_MeTrfase_MraW_recog
Pfam Domains: PF01795 - MraW methylase family
SCOP Domains: 81799 - Putative methyltransferase TM0872, insert domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases
ModBase Predicted Comparative 3D Structure on A6NJ78
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC066900 - Homo sapiens methyltransferase 5 domain containing 1, mRNA (cDNA clone IMAGE:5259156).BC030997 - Homo sapiens methyltransferase 5 domain containing 1, mRNA (cDNA clone MGC:32708 IMAGE:4657323), complete cds.AK091298 - Homo sapiens cDNA FLJ33979 fis, clone DFNES2004371.AX746902 - Sequence 427 from Patent EP1308459.AL832668 - Homo sapiens mRNA; cDNA DKFZp313M2112 (from clone DKFZp313M2112).CU689070 - Synthetic construct Homo sapiens gateway clone IMAGE:100022108 5' read METT5D1 mRNA.KJ903973 - Synthetic construct Homo sapiens clone ccsbBroadEn_13367 METTL15 gene, encodes complete protein.BC105287 - Homo sapiens methyltransferase 5 domain containing 1, mRNA (cDNA clone IMAGE:4075612), complete cds.JD523682 - Sequence 504706 from Patent EP1572962.AL713720 - Homo sapiens mRNA; cDNA DKFZp667L2116 (from clone DKFZp667L2116).JD110787 - Sequence 91811 from Patent EP1572962.JD509998 - Sequence 491022 from Patent EP1572962.JD258217 - Sequence 239241 from Patent EP1572962.JD359785 - Sequence 340809 from Patent EP1572962.JD433768 - Sequence 414792 from Patent EP1572962.JD324551 - Sequence 305575 from Patent EP1572962.JD108426 - Sequence 89450 from Patent EP1572962.JD549170 - Sequence 530194 from Patent EP1572962.JD233458 - Sequence 214482 from Patent EP1572962.JD205358 - Sequence 186382 from Patent EP1572962.JD361069 - Sequence 342093 from Patent EP1572962.JD045447 - Sequence 26471 from Patent EP1572962.JD160239 - Sequence 141263 from Patent EP1572962.JD213975 - Sequence 194999 from Patent EP1572962.JD562683 - Sequence 543707 from Patent EP1572962.JD549354 - Sequence 530378 from Patent EP1572962.JD172031 - Sequence 153055 from Patent EP1572962.JD126347 - Sequence 107371 from Patent EP1572962.JD521379 - Sequence 502403 from Patent EP1572962.JD246837 - Sequence 227861 from Patent EP1572962.JD246896 - Sequence 227920 from Patent EP1572962.JD287425 - Sequence 268449 from Patent EP1572962.JD286018 - Sequence 267042 from Patent EP1572962.JD193972 - Sequence 174996 from Patent EP1572962.JD105599 - Sequence 86623 from Patent EP1572962.JD158821 - Sequence 139845 from Patent EP1572962.JD275676 - Sequence 256700 from Patent EP1572962.JD208643 - Sequence 189667 from Patent EP1572962.JD111730 - Sequence 92754 from Patent EP1572962.JD118502 - Sequence 99526 from Patent EP1572962.JD063047 - Sequence 44071 from Patent EP1572962.JD404407 - Sequence 385431 from Patent EP1572962.JD435034 - Sequence 416058 from Patent EP1572962.JD307192 - Sequence 288216 from Patent EP1572962.JD323075 - Sequence 304099 from Patent EP1572962.JD182500 - Sequence 163524 from Patent EP1572962.JD512521 - Sequence 493545 from Patent EP1572962.JD097446 - Sequence 78470 from Patent EP1572962.JD050851 - Sequence 31875 from Patent EP1572962.JD482588 - Sequence 463612 from Patent EP1572962.JD087623 - Sequence 68647 from Patent EP1572962.JD530386 - Sequence 511410 from Patent EP1572962.JD437173 - Sequence 418197 from Patent EP1572962.JD310917 - Sequence 291941 from Patent EP1572962.JD564897 - Sequence 545921 from Patent EP1572962.JD292348 - Sequence 273372 from Patent EP1572962.JD363683 - Sequence 344707 from Patent EP1572962.JD160269 - Sequence 141293 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A6NJ78, A8MRS5, B7WNU2, MET15_HUMAN, METT5D1, NM_001113528, NP_001107000, Q3MHD3, Q8N601, Q8NBA7UCSC ID: uc001msh.2RefSeq Accession: NM_001113528
Protein: A6NJ78
(aka MET15_HUMAN)
CCDS: CCDS44559.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001113528.1
exon count:
7 CDS single in 3' UTR:
no
RNA size:
4345
ORF size:
1224 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2648.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.