Human Gene METTL15 (uc001msh.2)
  Description: Homo sapiens methyltransferase like 15 (METTL15), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:28,129,798-28,355,054 Size: 225,257 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr11:28,134,882-28,352,388 Size: 217,507 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:28,129,798-28,355,054)mRNA (may differ from genome)Protein (407 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MET15_HUMAN
DESCRIPTION: RecName: Full=Probable methyltransferase-like protein 15; EC=2.1.1.-; AltName: Full=Methyltransferase 5 domain-containing protein 1;
FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase (By similarity).
SIMILARITY: Belongs to the methyltransferase superfamily. RsmH family.
SEQUENCE CAUTION: Sequence=AAH30997.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.15 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 136.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -203.70455-0.448 Picture PostScript Text
3' UTR -646.692666-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002903 - SAM-dep_MeTrfase_MraW
IPR023397 - SAM-dep_MeTrfase_MraW_recog

Pfam Domains:
PF01795 - MraW methylase family

SCOP Domains:
81799 - Putative methyltransferase TM0872, insert domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on A6NJ78
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsemblFlyBase  
 Protein SequenceProtein SequenceProtein Sequence  
 AlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity

Biological Process:
GO:0032259 methylation
GO:0070475 rRNA base methylation


-  Descriptions from all associated GenBank mRNAs
  BC066900 - Homo sapiens methyltransferase 5 domain containing 1, mRNA (cDNA clone IMAGE:5259156).
BC030997 - Homo sapiens methyltransferase 5 domain containing 1, mRNA (cDNA clone MGC:32708 IMAGE:4657323), complete cds.
AK091298 - Homo sapiens cDNA FLJ33979 fis, clone DFNES2004371.
AX746902 - Sequence 427 from Patent EP1308459.
AL832668 - Homo sapiens mRNA; cDNA DKFZp313M2112 (from clone DKFZp313M2112).
CU689070 - Synthetic construct Homo sapiens gateway clone IMAGE:100022108 5' read METT5D1 mRNA.
KJ903973 - Synthetic construct Homo sapiens clone ccsbBroadEn_13367 METTL15 gene, encodes complete protein.
BC105287 - Homo sapiens methyltransferase 5 domain containing 1, mRNA (cDNA clone IMAGE:4075612), complete cds.
JD523682 - Sequence 504706 from Patent EP1572962.
AL713720 - Homo sapiens mRNA; cDNA DKFZp667L2116 (from clone DKFZp667L2116).
JD110787 - Sequence 91811 from Patent EP1572962.
JD509998 - Sequence 491022 from Patent EP1572962.
JD258217 - Sequence 239241 from Patent EP1572962.
JD359785 - Sequence 340809 from Patent EP1572962.
JD433768 - Sequence 414792 from Patent EP1572962.
JD324551 - Sequence 305575 from Patent EP1572962.
JD108426 - Sequence 89450 from Patent EP1572962.
JD549170 - Sequence 530194 from Patent EP1572962.
JD233458 - Sequence 214482 from Patent EP1572962.
JD205358 - Sequence 186382 from Patent EP1572962.
JD361069 - Sequence 342093 from Patent EP1572962.
JD045447 - Sequence 26471 from Patent EP1572962.
JD160239 - Sequence 141263 from Patent EP1572962.
JD213975 - Sequence 194999 from Patent EP1572962.
JD562683 - Sequence 543707 from Patent EP1572962.
JD549354 - Sequence 530378 from Patent EP1572962.
JD172031 - Sequence 153055 from Patent EP1572962.
JD126347 - Sequence 107371 from Patent EP1572962.
JD521379 - Sequence 502403 from Patent EP1572962.
JD246837 - Sequence 227861 from Patent EP1572962.
JD246896 - Sequence 227920 from Patent EP1572962.
JD287425 - Sequence 268449 from Patent EP1572962.
JD286018 - Sequence 267042 from Patent EP1572962.
JD193972 - Sequence 174996 from Patent EP1572962.
JD105599 - Sequence 86623 from Patent EP1572962.
JD158821 - Sequence 139845 from Patent EP1572962.
JD275676 - Sequence 256700 from Patent EP1572962.
JD208643 - Sequence 189667 from Patent EP1572962.
JD111730 - Sequence 92754 from Patent EP1572962.
JD118502 - Sequence 99526 from Patent EP1572962.
JD063047 - Sequence 44071 from Patent EP1572962.
JD404407 - Sequence 385431 from Patent EP1572962.
JD435034 - Sequence 416058 from Patent EP1572962.
JD307192 - Sequence 288216 from Patent EP1572962.
JD323075 - Sequence 304099 from Patent EP1572962.
JD182500 - Sequence 163524 from Patent EP1572962.
JD512521 - Sequence 493545 from Patent EP1572962.
JD097446 - Sequence 78470 from Patent EP1572962.
JD050851 - Sequence 31875 from Patent EP1572962.
JD482588 - Sequence 463612 from Patent EP1572962.
JD087623 - Sequence 68647 from Patent EP1572962.
JD530386 - Sequence 511410 from Patent EP1572962.
JD437173 - Sequence 418197 from Patent EP1572962.
JD310917 - Sequence 291941 from Patent EP1572962.
JD564897 - Sequence 545921 from Patent EP1572962.
JD292348 - Sequence 273372 from Patent EP1572962.
JD363683 - Sequence 344707 from Patent EP1572962.
JD160269 - Sequence 141293 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NJ78, A8MRS5, B7WNU2, MET15_HUMAN, METT5D1, NM_001113528, NP_001107000, Q3MHD3, Q8N601, Q8NBA7
UCSC ID: uc001msh.2
RefSeq Accession: NM_001113528
Protein: A6NJ78 (aka MET15_HUMAN)
CCDS: CCDS44559.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001113528.1
exon count: 7CDS single in 3' UTR: no RNA size: 4345
ORF size: 1224CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2648.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.