Human Gene CHUK (uc001kqp.3) Description and Page Index
  Description: Homo sapiens conserved helix-loop-helix ubiquitous kinase (CHUK), mRNA.
RefSeq Summary (NM_001278): This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.165077.1, SRR1803617.19857.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370397.8/ ENSP00000359424.6 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr10:101,948,124-101,989,344 Size: 41,221 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr10:101,949,355-101,989,289 Size: 39,935 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:101,948,124-101,989,344)mRNA (may differ from genome)Protein (745 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: IKKA_HUMAN
DESCRIPTION: RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit alpha; Short=I-kappa-B kinase alpha; Short=IKK-A; Short=IKK-alpha; Short=IkBKA; Short=IkappaB kinase; EC=2.7.11.10; AltName: Full=Conserved helix-loop-helix ubiquitous kinase; AltName: Full=I-kappa-B kinase 1; Short=IKK1; AltName: Full=Nuclear factor NF-kappa-B inhibitor kinase alpha; Short=NFKBIKA; AltName: Full=Transcription factor 16; Short=TCF-16;
FUNCTION: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa- B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.
CATALYTIC ACTIVITY: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
ENZYME REGULATION: Activated when phosphorylated and inactivated when dephosphorylated.
SUBUNIT: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK- beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Directly interacts with IKK-gamma/NEMO and TRPC4AP (By similarity). May interact with TRAF2. Interacts with NALP2. May interact with MAVS/IPS1. Interacts with ARRB1 and ARRB2. Interacts with NLRC5; prevents CHUK phosphorylation and kinase activity. Interacts with PIAS1; this interaction induces PIAS1 phosphorylation.
INTERACTION: O14920:IKBKB; NbExp=7; IntAct=EBI-81249, EBI-81266; Q9Y6K9:IKBKG; NbExp=12; IntAct=EBI-81249, EBI-81279; Q99558:MAP3K14; NbExp=4; IntAct=EBI-81249, EBI-358011; P01106:MYC; NbExp=3; IntAct=EBI-81249, EBI-447544; P25963:NFKBIA; NbExp=6; IntAct=EBI-81249, EBI-307386; Q04206:RELA; NbExp=2; IntAct=EBI-81249, EBI-73886; Q86VP1:TAX1BP1; NbExp=2; IntAct=EBI-81249, EBI-529518; P24772:VACWR196 (xeno); NbExp=3; IntAct=EBI-81249, EBI-4291651;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
TISSUE SPECIFICITY: Widely expressed.
DOMAIN: The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero- dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
PTM: Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
PTM: Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
DISEASE: Defects in CHUK are the cause of cocoon syndrome (COCOS) [MIM:613630]; also known as fetal encasement syndrome. COCOS is a lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin.
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
SIMILARITY: Contains 1 protein kinase domain.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/chuk/";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CHUK
CDC HuGE Published Literature: CHUK
Positive Disease Associations: Arthritis, Rheumatoid|Rheumatoid Arthritis|Anti-TNF Response , plasma levels of liver enzymes
Related Studies:
  1. Arthritis, Rheumatoid|Rheumatoid Arthritis|Anti-TNF Response
    Potter C et al. 2010, Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways., Annals of the rheumatic diseases 69(7) : 1315-20 2010. [PubMed 20448286]
    Several SNPs mapping to the TLR and NFkappaB signalling systems demonstrated association with anti-TNF response as a whole and, in particular, with response to etanercept. Validation of these findings in an independent cohort is now warranted.
  2. plasma levels of liver enzymes
    Yuan ,et al. 2008, Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes, American journal of human genetics 2008 83- 4 : 520-8. [PubMed 18940312]

-  MalaCards Disease Associations
  MalaCards Gene Search: CHUK
Diseases sorted by gene-association score: cocoon syndrome* (1276), ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive (10), popliteal pterygium syndrome 1 (8), hepatitis c virus (3), prostate cancer (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.31 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 124.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.7055-0.285 Picture PostScript Text
3' UTR -289.831231-0.235 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022007 - IKKbetaNEMObind
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF12179 - I-kappa-kinase-beta NEMO binding domain

SCOP Domains:
56112 - Protein kinase-like (PK-like)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3BRT
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O15111
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008384 IkappaB kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0097110 scaffold protein binding

Biological Process:
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003009 skeletal muscle contraction
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0007266 Rho protein signal transduction
GO:0009615 response to virus
GO:0009636 response to toxic substance
GO:0009653 anatomical structure morphogenesis
GO:0010033 response to organic substance
GO:0010034 response to acetate
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0033194 response to hydroperoxide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034614 cellular response to reactive oxygen species
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 response to amino acid
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071276 cellular response to cadmium ion
GO:0071356 cellular response to tumor necrosis factor
GO:0098586 cellular response to virus
GO:1902741 positive regulation of interferon-alpha secretion

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008385 IkappaB kinase complex
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC092514 - Homo sapiens conserved helix-loop-helix ubiquitous kinase, mRNA (cDNA clone MGC:104955 IMAGE:3063613), complete cds.
AF080157 - Homo sapiens IkB kinase-a (IKK-alpha) mRNA, complete cds.
AB209028 - Homo sapiens mRNA for conserved helix-loop-helix ubiquitous kinase variant protein.
U22512 - Human helix-loop-helix protein CHUK mRNA, complete cds.
AF012890 - Homo sapiens IKK-a kinase (IKK-a) mRNA, complete cds.
AF009225 - Homo sapiens IkB kinase alpha subunit (IKK alpha) mRNA, complete cds.
AB590489 - Synthetic construct DNA, clone: pFN21AE2076, Homo sapiens CHUK gene for conserved helix-loop-helix ubiquitous kinase, without stop codon, in Flexi system.
BC034796 - Homo sapiens conserved helix-loop-helix ubiquitous kinase, mRNA (cDNA clone IMAGE:4826379).
AL133012 - Homo sapiens mRNA; cDNA DKFZp566L084 (from clone DKFZp566L084).
JD288259 - Sequence 269283 from Patent EP1572962.
JD503847 - Sequence 484871 from Patent EP1572962.
JD343297 - Sequence 324321 from Patent EP1572962.
JD449248 - Sequence 430272 from Patent EP1572962.
JD360338 - Sequence 341362 from Patent EP1572962.
JD537503 - Sequence 518527 from Patent EP1572962.
JD454565 - Sequence 435589 from Patent EP1572962.
JD318627 - Sequence 299651 from Patent EP1572962.
JD362839 - Sequence 343863 from Patent EP1572962.
JD313481 - Sequence 294505 from Patent EP1572962.
JD070674 - Sequence 51698 from Patent EP1572962.
JD240679 - Sequence 221703 from Patent EP1572962.
JD348762 - Sequence 329786 from Patent EP1572962.
JD547123 - Sequence 528147 from Patent EP1572962.
JD287543 - Sequence 268567 from Patent EP1572962.
JD499880 - Sequence 480904 from Patent EP1572962.
JD295775 - Sequence 276799 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04210 - Apoptosis
hsa04620 - Toll-like receptor signaling pathway
hsa04621 - NOD-like receptor signaling pathway
hsa04622 - RIG-I-like receptor signaling pathway
hsa04623 - Cytosolic DNA-sensing pathway
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04920 - Adipocytokine signaling pathway
hsa05120 - Epithelial cell signaling in Helicobacter pylori infection
hsa05131 - Shigellosis
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05212 - Pancreatic cancer
hsa05215 - Prostate cancer
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05222 - Small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_tall1Pathway - TACI and BCMA stimulation of B cell immune responses.
h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
h_RELAPathway - Acetylation and Deacetylation of RelA in The Nucleus
h_41bbPathway - The 4-1BB-dependent immune response
h_mapkPathway - MAPKinase Signaling Pathway
h_stressPathway - TNF/Stress Related Signaling
h_tnfr2Pathway - TNFR2 Signaling Pathway
h_nfkbPathway - NF-kB Signaling Pathway
h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_aktPathway - AKT Signaling Pathway
h_il1rPathway - Signal transduction through IL1R
h_keratinocytePathway - Keratinocyte Differentiation
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_cd40Pathway - CD40L Signaling Pathway
h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors
h_rasPathway - Ras Signaling Pathway
h_rnaPathway - Double Stranded RNA Induced Gene Expression
h_tollPathway - Toll-Like Receptor Pathway

Reactome (by CSHL, EBI, and GO)

Protein O15111 (Reactome details) participates in the following event(s):

R-HSA-198611 AKT phosphorylates IKKalpha
R-HSA-2400001 AKT1 E17K mutant phosphorylates CHUK (IKKalpha)
R-HSA-5609665 IKBKA, IKBKB and IKBKG form IKK complex
R-HSA-168184 Activated TAK1 mediates phosphorylation of the IKK Complex
R-HSA-168910 RIP1 facilitates IKK complex phosphorylation
R-HSA-202500 Activation of IKK complex
R-HSA-451561 NEMO binds polyubiquitinated IRAK1
R-HSA-933530 Activation of IKK by MEKK1
R-HSA-933539 Recruitment of IKK complex
R-HSA-937029 IKBKG subunit of IKK complex binds polyubiquinated RIP1
R-HSA-937032 NEMO subunit of IKK complex binds to activated IRAK1
R-HSA-975119 NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
R-HSA-2730876 Phosphorylation of IKK-beta by TAK1
R-HSA-5357776 TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
R-HSA-5607742 K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
R-HSA-5626962 GNB2L1 binds IKKA:IKKB:NEMO
R-HSA-9014343 IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
R-HSA-1168641 TAK1 associated with the CBM complex phosphorylates IKKbeta
R-HSA-5607722 Active NIK phosphorylates IKKA dimer
R-HSA-8863895 IKKB phosphorylates SNAP23
R-HSA-202541 p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
R-HSA-1168638 Activated IKK phosphorylates I-kappaB
R-HSA-168140 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
R-HSA-5357831 CYLD is phosphorylated by IKK
R-HSA-5684267 IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
R-HSA-5684275 IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
R-HSA-5607720 p100:RELB binds active NIK:p-IKKA dimer
R-HSA-5607726 Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB
R-HSA-5607723 SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-5602636 IKBKB deficiency causes SCID
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-9020702 Interleukin-1 signaling
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-202424 Downstream TCR signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937039 IRAK1 recruits IKK complex
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-5602358 Diseases associated with the TLR signaling cascade
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-446652 Interleukin-1 family signaling
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs
R-HSA-202403 TCR signaling
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-75893 TNF signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-1236974 ER-Phagosome pathway
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-5663202 Diseases of signal transduction
R-HSA-5260271 Diseases of Immune System
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-168249 Innate Immune System
R-HSA-449147 Signaling by Interleukins
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-1280218 Adaptive Immune System
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-73887 Death Receptor Signalling
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-450294 MAP kinase activation
R-HSA-168256 Immune System
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-448424 Interleukin-17 signaling

-  Other Names for This Gene
  Alternate Gene Symbols: IKKA, IKKA_HUMAN, NM_001278, NP_001269, O14666, O15111, Q13132, Q5W0I4, Q92467, TCF16
UCSC ID: uc001kqp.3
RefSeq Accession: NM_001278
Protein: O15111 (aka IKKA_HUMAN)
CCDS: CCDS7488.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001278.3
exon count: 21CDS single in 3' UTR: no RNA size: 3539
ORF size: 2238CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4676.00frame shift in genome: no % Coverage: 99.58
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.