Human Gene IPP (uc001cou.3) Description and Page Index
  Description: Homo sapiens intracisternal A particle-promoted polypeptide (IPP), transcript variant 1, mRNA.
RefSeq Summary (NM_005897): The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr1:46,164,407-46,216,485 Size: 52,079 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr1:46,165,638-46,212,083 Size: 46,446 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:46,164,407-46,216,485)mRNA (may differ from genome)Protein (584 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Actin-binding protein IPP; AltName: Full=Intracisternal A particle-promoted polypeptide; Short=IPP; AltName: Full=Kelch-like protein 27;
FUNCTION: May play a role in organizing the actin cytoskeleton.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 6 Kelch repeats.

-  MalaCards Disease Associations
  MalaCards Gene Search: IPP
Diseases sorted by gene-association score: cardiac tamponade (2), peroneal nerve paralysis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.94 RPKM in Testis
Total median expression: 111.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.70267-0.403 Picture PostScript Text
3' UTR -368.621231-0.299 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR015916 - Gal_Oxidase_b-propeller
IPR017096 - Kelch-like_gigaxonin
IPR006652 - Kelch_1

Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07646 - Kelch motif
PF07707 - BTB And C-terminal Kelch
PF13415 - Galactose oxidase, central domain
PF13418 - Galactose oxidase, central domain
PF13854 - Kelch motif
PF13964 - Kelch motif

SCOP Domains:
50965 - Galactose oxidase, central domain
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q9Y573
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  Protein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0016567 protein ubiquitination

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0031463 Cul3-RING ubiquitin ligase complex

-  Descriptions from all associated GenBank mRNAs
  BC032544 - Homo sapiens intracisternal A particle-promoted polypeptide, mRNA (cDNA clone MGC:45221 IMAGE:5535760), complete cds.
AF156857 - Homo sapiens actin-binding protein (IPP) mRNA, complete cds.
JD097612 - Sequence 78636 from Patent EP1572962.
JD189740 - Sequence 170764 from Patent EP1572962.
JD269526 - Sequence 250550 from Patent EP1572962.
JD281944 - Sequence 262968 from Patent EP1572962.
JD296372 - Sequence 277396 from Patent EP1572962.
JD093034 - Sequence 74058 from Patent EP1572962.
JD184164 - Sequence 165188 from Patent EP1572962.
JD066787 - Sequence 47811 from Patent EP1572962.
JD176539 - Sequence 157563 from Patent EP1572962.
JD458028 - Sequence 439052 from Patent EP1572962.
JD376991 - Sequence 358015 from Patent EP1572962.
JD165422 - Sequence 146446 from Patent EP1572962.
JD545855 - Sequence 526879 from Patent EP1572962.
JD277681 - Sequence 258705 from Patent EP1572962.
JD145931 - Sequence 126955 from Patent EP1572962.
JD482773 - Sequence 463797 from Patent EP1572962.
JD441842 - Sequence 422866 from Patent EP1572962.
JD065823 - Sequence 46847 from Patent EP1572962.
JD476049 - Sequence 457073 from Patent EP1572962.
JD278387 - Sequence 259411 from Patent EP1572962.
JD168144 - Sequence 149168 from Patent EP1572962.
JD214297 - Sequence 195321 from Patent EP1572962.
JD355535 - Sequence 336559 from Patent EP1572962.
JD209652 - Sequence 190676 from Patent EP1572962.
JD510277 - Sequence 491301 from Patent EP1572962.
JD037295 - Sequence 18319 from Patent EP1572962.
AK023880 - Homo sapiens cDNA FLJ13818 fis, clone THYRO1000395, highly similar to Actin-binding protein IPP.
JD381484 - Sequence 362508 from Patent EP1572962.
JD269546 - Sequence 250570 from Patent EP1572962.
JD354005 - Sequence 335029 from Patent EP1572962.
JD452566 - Sequence 433590 from Patent EP1572962.
JD377974 - Sequence 358998 from Patent EP1572962.
JD249532 - Sequence 230556 from Patent EP1572962.
JD085084 - Sequence 66108 from Patent EP1572962.
JD447655 - Sequence 428679 from Patent EP1572962.
JD139360 - Sequence 120384 from Patent EP1572962.
JD056898 - Sequence 37922 from Patent EP1572962.
JD240312 - Sequence 221336 from Patent EP1572962.
JD387982 - Sequence 369006 from Patent EP1572962.
JD201416 - Sequence 182440 from Patent EP1572962.
JD199431 - Sequence 180455 from Patent EP1572962.
JD479485 - Sequence 460509 from Patent EP1572962.
JD454069 - Sequence 435093 from Patent EP1572962.
JD375958 - Sequence 356982 from Patent EP1572962.
JD454068 - Sequence 435092 from Patent EP1572962.
JD187864 - Sequence 168888 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2A6V4, D3DQ11, IPP_HUMAN, KLHL27, NM_005897, NP_005888, Q8N5C3, Q9Y573
UCSC ID: uc001cou.3
RefSeq Accession: NM_005897
Protein: Q9Y573 (aka IPP_HUMAN)
CCDS: CCDS30702.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_005897.2
exon count: 9CDS single in 3' UTR: no RNA size: 3269
ORF size: 1755CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3686.00frame shift in genome: no % Coverage: 99.51
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 1335# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.