Human Gene IGSF3 (uc031pnr.1) Description and Page Index
Description: Homo sapiens immunoglobulin superfamily, member 3 (IGSF3), transcript variant 1, mRNA. RefSeq Summary (NM_001542): The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016]. Transcript (Including UTRs) Position: hg19 chr1:117,117,020-117,209,578 Size: 92,559 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr1:117,119,934-117,208,948 Size: 89,015 Coding Exon Count: 11
ID:A6NJZ6_HUMAN DESCRIPTION: SubName: Full=Immunoglobulin superfamily member 3; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
MalaCards Disease Associations
MalaCards Gene Search: IGSF3 Diseases sorted by gene-association score: lacrimal duct defect* (1319) * = Manually curated disease association
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A6NJZ6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.