Human Gene TTC22 (uc009vzt.1) Description and Page Index
  Description: Homo sapiens tetratricopeptide repeat domain 22 (TTC22), transcript variant 1, mRNA.
RefSeq Summary (NM_001114108): This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011].
Transcript (Including UTRs)
   Position: hg19 chr1:55,246,752-55,266,941 Size: 20,190 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr1:55,246,916-55,266,836 Size: 19,921 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:55,246,752-55,266,941)mRNA (may differ from genome)Protein (569 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TTC22_HUMAN
DESCRIPTION: RecName: Full=Tetratricopeptide repeat protein 22; Short=TPR repeat protein 22;
SIMILARITY: Contains 7 TPR repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.09 RPKM in Esophagus - Mucosa
Total median expression: 171.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.50105-0.462 Picture PostScript Text
3' UTR -69.60164-0.424 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on Q5TAA0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Descriptions from all associated GenBank mRNAs
  AL049431 - Homo sapiens mRNA; cDNA DKFZp586J211 (from clone DKFZp586J211).
AK000626 - Homo sapiens cDNA FLJ20619 fis, clone KAT05037.
JD375130 - Sequence 356154 from Patent EP1572962.
JD368938 - Sequence 349962 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001114108, NP_001107580, Q5TAA0, Q9NWT4, TTC22_HUMAN
UCSC ID: uc009vzt.1
RefSeq Accession: NM_001114108
Protein: Q5TAA0 (aka TTC22_HUMAN)
CCDS: CCDS44152.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001114108.1
exon count: 7CDS single in 3' UTR: no RNA size: 1979
ORF size: 1710CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 3047.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.