Human Gene CLDN23 (uc003wsi.3) Description and Page Index
Description: Homo sapiens claudin 23 (CLDN23), mRNA. RefSeq Summary (NM_194284): This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR6380200.29125.21, SRR7346977.1094289.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr8:8,559,666-8,561,617 Size: 1,952 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chr8:8,559,909-8,560,787 Size: 879 Coding Exon Count: 1
ID:CLD23_HUMAN DESCRIPTION: RecName: Full=Claudin-23; FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). SUBCELLULAR LOCATION: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor. SIMILARITY: Belongs to the claudin family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CLDN23 CDC HuGE Published Literature: CLDN23 Positive Disease Associations: Stroke Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00822 - PMP-22/EMP/MP20/Claudin family
ModBase Predicted Comparative 3D Structure on Q96B33
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.