ID:IRX4_HUMAN DESCRIPTION: RecName: Full=Iroquois-class homeodomain protein IRX-4; AltName: Full=Homeodomain protein IRXA3; AltName: Full=Iroquois homeobox protein 4; FUNCTION: Likely to be an important mediator of ventricular differentiation during cardiac development. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Predominantly expressed in cardiac ventricles. SIMILARITY: Belongs to the TALE/IRO homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
Genetic Association Studies of Complex Diseases and Disorders
Cardiovascular Diseases Markus Schurks et al. PloS one 2011, Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study., PloS one.
Our results provide some suggestion for an association of five SNPs with CVD events among women with migraine; none of the results was genome-wide significant. Four associations appeared among migraineurs with aura, two of those with ischemic stroke. Although our population is among the largest with migraine and incident CVD information, these results must be treated with caution, given the limited number of CVD events among women with migraine and the low minor allele frequencies for three of the SNPs. Our results await independent replication and should be considered hypothesis generating for future research.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78413
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007507 heart development GO:0048561 establishment of animal organ orientation