Human Gene RIPK4 (uc002yzn.1) Description and Page Index
  Description: Homo sapiens receptor-interacting serine-threonine kinase 4 (RIPK4), mRNA.
RefSeq Summary (NM_020639): The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ278016.1, AB047783.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000332512.8/ ENSP00000332454.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr21:43,159,529-43,187,249 Size: 27,721 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr21:43,160,998-43,187,201 Size: 26,204 Coding Exon Count: 8 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr21:43,159,529-43,187,249)mRNA (may differ from genome)Protein (784 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RIPK4
CDC HuGE Published Literature: RIPK4

-  MalaCards Disease Associations
  MalaCards Gene Search: RIPK4
Diseases sorted by gene-association score: popliteal pterygium syndrome, bartsocas-papas type* (1300), mesenteric lymphadenitis (16), cocoon syndrome (13), popliteal pterygium syndrome 1 (12), myiasis (8), chronic cervicitis (8), synostosis (5), van der woude syndrome (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.56 RPKM in Esophagus - Mucosa
Total median expression: 172.11 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.5048-0.469 Picture PostScript Text
3' UTR -545.301469-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00023 - Ankyrin repeat
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
56112 - Protein kinase-like (PK-like)
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on P57078-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Descriptions from all associated GenBank mRNAs
  AB047783 - Homo sapiens ANKRD3 mRNA for dual-specificity Ser/Thr/Tyr kinase, complete cds.
BC035755 - Homo sapiens receptor-interacting serine-threonine kinase 4, mRNA (cDNA clone IMAGE:5760485).
AJ278016 - Homo sapiens mRNA for protein kinase (dik gene).
AL137448 - Homo sapiens mRNA; cDNA DKFZp434B2328 (from clone DKFZp434B2328).
AK027424 - Homo sapiens cDNA FLJ14518 fis, clone NT2RM1000850, weakly similar to ANKYRIN R.
JD091074 - Sequence 72098 from Patent EP1572962.
JD119621 - Sequence 100645 from Patent EP1572962.
JD143906 - Sequence 124930 from Patent EP1572962.
JD182919 - Sequence 163943 from Patent EP1572962.
JD220758 - Sequence 201782 from Patent EP1572962.
JD163532 - Sequence 144556 from Patent EP1572962.
JD155701 - Sequence 136725 from Patent EP1572962.
JD494602 - Sequence 475626 from Patent EP1572962.
JD227766 - Sequence 208790 from Patent EP1572962.
JD280014 - Sequence 261038 from Patent EP1572962.
JD432740 - Sequence 413764 from Patent EP1572962.
JD315053 - Sequence 296077 from Patent EP1572962.
AF308292 - Homo sapiens serologically defined breast cancer antigen NY-BR-49 mRNA, partial cds.
JD536395 - Sequence 517419 from Patent EP1572962.
JD266754 - Sequence 247778 from Patent EP1572962.
AK296685 - Homo sapiens cDNA FLJ50981 complete cds, highly similar to Receptor-interacting serine/threonine-protein kinase 4 (EC
JD158036 - Sequence 139060 from Patent EP1572962.
JD489888 - Sequence 470912 from Patent EP1572962.
JD448568 - Sequence 429592 from Patent EP1572962.
AK302592 - Homo sapiens cDNA FLJ51151 complete cds, highly similar to Receptor-interacting serine/threonine-protein kinase 4 (EC
AK316412 - Homo sapiens cDNA, FLJ79311 complete cds, highly similar to Receptor-interacting serine/threonine-protein kinase 4 (EC
JD149824 - Sequence 130848 from Patent EP1572962.
JD221403 - Sequence 202427 from Patent EP1572962.
JD053642 - Sequence 34666 from Patent EP1572962.
JD429206 - Sequence 410230 from Patent EP1572962.
BC110617 - Homo sapiens receptor-interacting serine-threonine kinase 4, mRNA (cDNA clone MGC:129992 IMAGE:40034395), complete cds.
BC110618 - Homo sapiens receptor-interacting serine-threonine kinase 4, mRNA (cDNA clone MGC:129993 IMAGE:40034396), complete cds.
JD485069 - Sequence 466093 from Patent EP1572962.
JD151054 - Sequence 132078 from Patent EP1572962.
EU832165 - Synthetic construct Homo sapiens clone HAIB:100067194; DKFZo008G0825 receptor-interacting serine-threonine kinase 4 protein (RIPK4) gene, encodes complete protein.
EU832259 - Synthetic construct Homo sapiens clone HAIB:100067288; DKFZo004G0826 receptor-interacting serine-threonine kinase 4 protein (RIPK4) gene, encodes complete protein.
JD482989 - Sequence 464013 from Patent EP1572962.
JD452112 - Sequence 433136 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ANKRD3, DIK, NM_020639, NP_065690, P57078-2
UCSC ID: uc002yzn.1
RefSeq Accession: NM_020639
Protein: P57078-2, splice isoform of P57078 CCDS: CCDS13675.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_020639.2
exon count: 8CDS single in 3' UTR: no RNA size: 3890
ORF size: 2355CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4910.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.