Human Gene ALOX12 (uc002gdx.4) Description and Page Index
Description: Homo sapiens arachidonate 12-lipoxygenase (ALOX12), mRNA. RefSeq Summary (NM_000697): This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M62982.1, M35418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000251535.11/ ENSP00000251535.6 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr17:6,899,384-6,914,055 Size: 14,672 Total Exon Count: 14 Strand: + Coding Region Position: hg19 chr17:6,899,437-6,913,742 Size: 14,306 Coding Exon Count: 14
bipolar disorder Fridman, C. et al. 2003, Association of a new polymorphism in ALOX12 gene with bipolar disorder., European archives of psychiatry and clinical neuroscience. 2003 Feb;253(1):40-3.
An increased presence of allele A among patients was found, suggesting an association of this polymorphism with the BPD in this Brazilian sample.
bone density Ichikawa, S. et al. 2006, Human ALOX12, but Not ALOX15, Is Associated With BMD in White Men and Women, J Bone Miner Res 2006 21(4) 556-64.
Polymorphisms in the ALOX12 gene may contribute to normal variation in spine BMD.
bone density Mullin, B. H. et al. 2007, Polymorphisms in ALOX12, but not ALOX15, Are Significantly Associated With BMD in Postmenopausal Women, Calcif Tissue Int 2007.
we found no association between polymorphism in ALOX15 and BMD phenotypes but were able to replicate previous findings that genetic variation in ALOX12 seems to play a role in determining bone structure in Caucasian women.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P18054
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.