Human Gene MPZL3 (uc001psm.3) Description and Page Index
  Description: Homo sapiens myelin protein zero-like 3 (MPZL3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:118,100,336-118,123,011 Size: 22,676 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr11:118,100,609-118,123,009 Size: 22,401 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:118,100,336-118,123,011)mRNA (may differ from genome)Protein (235 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Myelin protein zero-like protein 3; Flags: Precursor;
FUNCTION: Mediates homophilic cell-cell adhesion (By similarity).
INTERACTION: O60487:MPZL2; NbExp=3; IntAct=EBI-4314854, EBI-3906725;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SIMILARITY: Belongs to the myelin P0 protein family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.83 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 173.94 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -68.32273-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013106 - Ig_V-set
IPR003596 - Ig_V-set_subgr
IPR000920 - Myelin_P0

Pfam Domains:
PF00047 - Immunoglobulin domain
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q6UWV2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007155 cell adhesion
GO:0030198 extracellular matrix organization
GO:0042633 hair cycle

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC008810 - Homo sapiens hypothetical protein LOC196264, mRNA (cDNA clone IMAGE:3948909), partial cds.
AK095399 - Homo sapiens cDNA FLJ38080 fis, clone CTONG2016185.
AK289390 - Homo sapiens cDNA FLJ78100 complete cds.
AK310966 - Homo sapiens cDNA, FLJ18008.
AK304292 - Homo sapiens cDNA FLJ53130 complete cds.
AK296951 - Homo sapiens cDNA FLJ51640 complete cds.
AY358626 - Homo sapiens clone DNA108792 QQRG2966 (UNQ2966) mRNA, complete cds.
JD073630 - Sequence 54654 from Patent EP1572962.
BC113586 - Homo sapiens myelin protein zero-like 3, mRNA (cDNA clone MGC:142146 IMAGE:8322638), complete cds.
BC143897 - Homo sapiens myelin protein zero-like 3, mRNA (cDNA clone MGC:177432 IMAGE:9052415), complete cds.
JD106560 - Sequence 87584 from Patent EP1572962.
JD158589 - Sequence 139613 from Patent EP1572962.
JD049501 - Sequence 30525 from Patent EP1572962.
JD304061 - Sequence 285085 from Patent EP1572962.
HQ258603 - Synthetic construct Homo sapiens clone IMAGE:100073145 myelin protein zero-like 3 (MPZL3) gene, encodes complete protein.
BC031223 - Homo sapiens hypothetical protein LOC196264, mRNA (cDNA clone IMAGE:4821236).
JD482277 - Sequence 463301 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K025, MPZL3_HUMAN, NM_198275, NP_938016, Q6UWV2, UNQ2966/PRO7425
UCSC ID: uc001psm.3
RefSeq Accession: NM_198275
Protein: Q6UWV2 (aka MPZL3_HUMAN)
CCDS: CCDS8392.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_198275.1
exon count: 6CDS single in 3' UTR: no RNA size: 983
ORF size: 708CDS single in intron: no Alignment % ID: 99.69
txCdsPredict score: 1516.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.