Human Gene ANXA8 (uc001jev.4) Description and Page Index
  Description: Homo sapiens annexin A8 (ANXA8), transcript variant 2, mRNA.
RefSeq Summary (NM_001098845): This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Apr 2014].
Transcript (Including UTRs)
   Position: hg19 chr10:48,255,204-48,271,368 Size: 16,165 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr10:48,255,429-48,270,515 Size: 15,087 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:48,255,204-48,271,368)mRNA (may differ from genome)Protein (327 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: AXA81_HUMAN
DESCRIPTION: RecName: Full=Annexin A8-like protein 1;
DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity).
SIMILARITY: Belongs to the annexin family.
SIMILARITY: Contains 4 annexin repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.10225-0.463 Picture PostScript Text
3' UTR -291.89853-0.342 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001464 - Annexin
IPR018502 - Annexin_repeat
IPR018252 - Annexin_repeat_CS
IPR009115 - AnnexinVIII

Pfam Domains:
PF00191 - Annexin

SCOP Domains:
47874 - Annexin

ModBase Predicted Comparative 3D Structure on Q5T2P8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK298761 - Homo sapiens cDNA FLJ56319 complete cds, highly similar to Annexin A8.
JD310037 - Sequence 291061 from Patent EP1572962.
BC073755 - Homo sapiens annexin A8, mRNA (cDNA clone MGC:88759 IMAGE:6538697), complete cds.
AK096715 - Homo sapiens cDNA FLJ39396 fis, clone PLACE6008640.
Z36830 - H.sapiens (xs22) mRNA, 445bp.
AK296976 - Homo sapiens cDNA FLJ58992 complete cds, moderately similar to Annexin A8.
BC004376 - Homo sapiens annexin A8, mRNA (cDNA clone MGC:10570 IMAGE:3639064), complete cds.
JD477369 - Sequence 458393 from Patent EP1572962.
X16662 - Human mRNA for vascular anticoagulant-beta (VAC-beta).
AK300158 - Homo sapiens cDNA FLJ57083 complete cds, highly similar to Annexin A8.
AK300139 - Homo sapiens cDNA FLJ53095 complete cds, highly similar to Annexin A8.
AK296573 - Homo sapiens cDNA FLJ58071 complete cds, highly similar to Annexin A8.
AK223149 - Homo sapiens mRNA for annexin A8 variant, clone: LNG00614.
M81844 - Human anexin VIII mRNA, complete cds.
KJ896330 - Synthetic construct Homo sapiens clone ccsbBroadEn_05724 ANXA8 gene, encodes complete protein.
CU687256 - Synthetic construct Homo sapiens gateway clone IMAGE:100023126 5' read ANXA8 mRNA.
AB590156 - Synthetic construct DNA, clone: pFN21AE1118, Homo sapiens ANXA8 gene for annexin A8, without stop codon, in Flexi system.
DQ893430 - Synthetic construct clone IMAGE:100006060; FLH199518.01X; RZPDo839G0282D annexin A8 (ANXA8) gene, encodes complete protein.
DQ896775 - Synthetic construct Homo sapiens clone IMAGE:100011235; FLH199424.01L; RZPDo839G0281D annexin A8 (ANXA8) gene, encodes complete protein.
KJ905685 - Synthetic construct Homo sapiens clone ccsbBroadEn_15355 ANXA8L2 gene, encodes complete protein.
JD049541 - Sequence 30565 from Patent EP1572962.
JD023905 - Sequence 4929 from Patent EP1572962.
JD030695 - Sequence 11719 from Patent EP1572962.
JD032652 - Sequence 13676 from Patent EP1572962.
JD147359 - Sequence 128383 from Patent EP1572962.
JD400471 - Sequence 381495 from Patent EP1572962.
JD150656 - Sequence 131680 from Patent EP1572962.
JD251898 - Sequence 232922 from Patent EP1572962.
JD042001 - Sequence 23025 from Patent EP1572962.
JD531937 - Sequence 512961 from Patent EP1572962.
JD170585 - Sequence 151609 from Patent EP1572962.
JD555526 - Sequence 536550 from Patent EP1572962.
JD466712 - Sequence 447736 from Patent EP1572962.
JD426962 - Sequence 407986 from Patent EP1572962.
JD151175 - Sequence 132199 from Patent EP1572962.
JD552667 - Sequence 533691 from Patent EP1572962.
JD122876 - Sequence 103900 from Patent EP1572962.
JD554665 - Sequence 535689 from Patent EP1572962.
JD056103 - Sequence 37127 from Patent EP1572962.
JD420276 - Sequence 401300 from Patent EP1572962.
JD390732 - Sequence 371756 from Patent EP1572962.
JD123459 - Sequence 104483 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NDE6, ANXA8L1, AXA81_HUMAN, NM_001098845, NP_001035173, Q5T2P8, uc001jev.3
UCSC ID: uc001jev.4
RefSeq Accession: NM_001098845
Protein: Q5T2P8 (aka AXA81_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001098845.1
exon count: 12CDS single in 3' UTR: no RNA size: 1954
ORF size: 984CDS single in intron: no Alignment % ID: 99.85
txCdsPredict score: 2366.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 776# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.