Human Gene ANXA8 (uc001jev.4) Description and Page Index
Description: Homo sapiens annexin A8 (ANXA8), transcript variant 2, mRNA. RefSeq Summary (NM_001098845): This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Apr 2014]. Transcript (Including UTRs) Position: hg19 chr10:48,255,204-48,271,368 Size: 16,165 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr10:48,255,429-48,270,515 Size: 15,087 Coding Exon Count: 12
ID:AXA81_HUMAN DESCRIPTION: RecName: Full=Annexin A8-like protein 1; DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity). SIMILARITY: Belongs to the annexin family. SIMILARITY: Contains 4 annexin repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5T2P8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.