Human Gene C1orf106 (uc001gvo.4) Description and Page Index
  Description: Homo sapiens chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:200,860,627-200,884,864 Size: 24,238 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr1:200,860,627-200,882,757 Size: 22,131 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:200,860,627-200,884,864)mRNA (may differ from genome)Protein (677 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CA106_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C1orf106;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C1orf106
CDC HuGE Published Literature: C1orf106
Positive Disease Associations: Colitis, Ulcerative
Related Studies:
  1. Colitis, Ulcerative
    Jeffrey C Barrett et al. Nature genetics 2009, Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region., Nature genetics. [PubMed 19915572]
  2. Colitis, Ulcerative
    Carl A Anderson et al. Nature genetics 2011, Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47., Nature genetics. [PubMed 21297633]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.27 RPKM in Small Intestine - Terminal Ileum
Total median expression: 120.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -770.892107-0.366 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021774 - DUF3338

Pfam Domains:
PF11819 - Domain of unknown function (DUF3338)

ModBase Predicted Comparative 3D Structure on Q3KP66
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000187 activation of MAPK activity
GO:0002221 pattern recognition receptor signaling pathway
GO:0002367 cytokine production involved in immune response
GO:0002376 immune system process
GO:0031398 positive regulation of protein ubiquitination
GO:0032494 response to peptidoglycan
GO:0032495 response to muramyl dipeptide
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0034334 adherens junction maintenance
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0060729 intestinal epithelial structure maintenance
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:1903409 reactive oxygen species biosynthetic process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK001583 - Homo sapiens cDNA FLJ10721 fis, clone NT2RP3001133.
KJ899190 - Synthetic construct Homo sapiens clone ccsbBroadEn_08584 C1orf106 gene, encodes complete protein.
BC106877 - Homo sapiens chromosome 1 open reading frame 106, mRNA (cDNA clone MGC:125608 IMAGE:40026425), complete cds.
AK001763 - Homo sapiens cDNA FLJ10901 fis, clone NT2RP5003524.
AK316510 - Homo sapiens cDNA, FLJ79409 complete cds, weakly similar to FERM domain-containing protein 4A.
AK303885 - Homo sapiens cDNA FLJ58417 complete cds, weakly similar to FERM domain-containing protein 4A.
JD442395 - Sequence 423419 from Patent EP1572962.
JD128567 - Sequence 109591 from Patent EP1572962.
JD455648 - Sequence 436672 from Patent EP1572962.
AK025066 - Homo sapiens cDNA: FLJ21413 fis, clone COL03991.
JD102674 - Sequence 83698 from Patent EP1572962.
JD174904 - Sequence 155928 from Patent EP1572962.
JD468281 - Sequence 449305 from Patent EP1572962.
JD161227 - Sequence 142251 from Patent EP1572962.
JD224283 - Sequence 205307 from Patent EP1572962.
JD052055 - Sequence 33079 from Patent EP1572962.
JD534350 - Sequence 515374 from Patent EP1572962.
JD087985 - Sequence 69009 from Patent EP1572962.
JD259664 - Sequence 240688 from Patent EP1572962.
JD122261 - Sequence 103285 from Patent EP1572962.
JD354254 - Sequence 335278 from Patent EP1572962.
JD478806 - Sequence 459830 from Patent EP1572962.
JD202201 - Sequence 183225 from Patent EP1572962.
JD079240 - Sequence 60264 from Patent EP1572962.
JD022848 - Sequence 3872 from Patent EP1572962.
JD029178 - Sequence 10202 from Patent EP1572962.
JD564189 - Sequence 545213 from Patent EP1572962.
JD052452 - Sequence 33476 from Patent EP1572962.
JD412470 - Sequence 393494 from Patent EP1572962.
JD431488 - Sequence 412512 from Patent EP1572962.
JD161564 - Sequence 142588 from Patent EP1572962.
JD522991 - Sequence 504015 from Patent EP1572962.
JD450148 - Sequence 431172 from Patent EP1572962.
JD298085 - Sequence 279109 from Patent EP1572962.
JD256739 - Sequence 237763 from Patent EP1572962.
JD407519 - Sequence 388543 from Patent EP1572962.
JD212931 - Sequence 193955 from Patent EP1572962.
JD212932 - Sequence 193956 from Patent EP1572962.
JD268816 - Sequence 249840 from Patent EP1572962.
JD095130 - Sequence 76154 from Patent EP1572962.
JD409273 - Sequence 390297 from Patent EP1572962.
JD489097 - Sequence 470121 from Patent EP1572962.
JD072178 - Sequence 53202 from Patent EP1572962.
JD207543 - Sequence 188567 from Patent EP1572962.
JD285382 - Sequence 266406 from Patent EP1572962.
JD505091 - Sequence 486115 from Patent EP1572962.
JD560832 - Sequence 541856 from Patent EP1572962.
JD106869 - Sequence 87893 from Patent EP1572962.
JD279711 - Sequence 260735 from Patent EP1572962.
JD174617 - Sequence 155641 from Patent EP1572962.
JD162486 - Sequence 143510 from Patent EP1572962.
JD230961 - Sequence 211985 from Patent EP1572962.
JD499126 - Sequence 480150 from Patent EP1572962.
JD062797 - Sequence 43821 from Patent EP1572962.
JD276140 - Sequence 257164 from Patent EP1572962.
JD350659 - Sequence 331683 from Patent EP1572962.
JD307216 - Sequence 288240 from Patent EP1572962.
JD207146 - Sequence 188170 from Patent EP1572962.
JD158680 - Sequence 139704 from Patent EP1572962.
JD258096 - Sequence 239120 from Patent EP1572962.
JD391461 - Sequence 372485 from Patent EP1572962.
JD290015 - Sequence 271039 from Patent EP1572962.
JD515952 - Sequence 496976 from Patent EP1572962.
JD421079 - Sequence 402103 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CA106_HUMAN, NM_018265, NP_060735, Q3KP66, Q9NV65, Q9NVI0, uc001gvo.3
UCSC ID: uc001gvo.4
RefSeq Accession: NM_018265
Protein: Q3KP66 (aka CA106_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_018265.3
exon count: 10CDS single in 3' UTR: no RNA size: 4161
ORF size: 2034CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4081.00frame shift in genome: no % Coverage: 99.52
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.