Human Gene TAS2R5 (uc003vwr.1) Description and Page Index
  Description: Homo sapiens taste receptor, type 2, member 5 (TAS2R5), mRNA.
RefSeq Summary (NM_018980): This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC095522.1, SRR1660803.244645.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000247883.5/ ENSP00000247883.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr7:141,490,017-141,491,166 Size: 1,150 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr7:141,490,162-141,491,061 Size: 900 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:141,490,017-141,491,166)mRNA (may differ from genome)Protein (299 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Taste receptor type 2 member 5; Short=T2R5;
FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells.
MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
SIMILARITY: Belongs to the G-protein coupled receptor T2R family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.54 RPKM in Brain - Cerebellum
Total median expression: 64.75 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.00145-0.324 Picture PostScript Text
3' UTR -28.10105-0.268 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007960 - TAS2_rcpt

Pfam Domains:
PF05296 - Taste receptor protein (TAS2R)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9NYW4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity

Biological Process:
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007635 chemosensory behavior
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC095522 - Homo sapiens taste receptor, type 2, member 5, mRNA (cDNA clone MGC:111740 IMAGE:30706589), complete cds.
BC101586 - Homo sapiens taste receptor, type 2, member 5, mRNA (cDNA clone MGC:126635 IMAGE:8069092), complete cds.
BC101588 - Homo sapiens taste receptor, type 2, member 5, mRNA (cDNA clone MGC:126637 IMAGE:8069094), complete cds.
CU686868 - Synthetic construct Homo sapiens gateway clone IMAGE:100022574 5' read TAS2R5 mRNA.
HQ448391 - Synthetic construct Homo sapiens clone IMAGE:100071818; CCSB013862_01 taste receptor, type 2, member 5 (TAS2R5) gene, encodes complete protein.
BC069509 - Homo sapiens taste receptor, type 2, member 5, mRNA (cDNA clone MGC:97007 IMAGE:7262216), complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04742 - Taste transduction

Reactome (by CSHL, EBI, and GO)

Protein Q9NYW4 (Reactome details) participates in the following event(s):

R-HSA-3296233 T2Rs bind bitter-tasting compounds
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_018980, NP_061853, Q645W0, Q75MV7, Q9NYW4, TA2R5_HUMAN
UCSC ID: uc003vwr.1
RefSeq Accession: NM_018980
Protein: Q9NYW4 (aka TA2R5_HUMAN or T2R5_HUMAN)
CCDS: CCDS5869.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_018980.2
exon count: 1CDS single in 3' UTR: no RNA size: 1150
ORF size: 900CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2000.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.