ID:ZKSC3_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein with KRAB and SCAN domains 3; AltName: Full=Zinc finger and SCAN domain-containing protein 13; AltName: Full=Zinc finger protein 306; AltName: Full=Zinc finger protein 309; AltName: Full=Zinc finger protein 47 homolog; Short=Zf47; Short=Zfp-47; FUNCTION: Acts as a transcriptional regulator. Binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3'. Associates with chromatin at the ITGB4 and VEGF promoters. Activates the transcription of genes associated with colon cancer progression. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in colorectal cancers (at protein level). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 7 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain. SIMILARITY: Contains 1 SCAN box domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BRR0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006914 autophagy GO:0007040 lysosome organization GO:0010507 negative regulation of autophagy GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:2000773 negative regulation of cellular senescence
US Server
