Human Gene SLC26A1 (uc003gcc.3) Description and Page Index
  Description: Homo sapiens solute carrier family 26 (sulfate transporter), member 1 (SLC26A1), transcript variant 3, mRNA.
RefSeq Summary (NM_022042): This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr4:981,445-987,224 Size: 5,780 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr4:982,621-985,491 Size: 2,871 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:981,445-987,224)mRNA (may differ from genome)Protein (701 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: S26A1_HUMAN
DESCRIPTION: RecName: Full=Sulfate anion transporter 1; Short=SAT-1; AltName: Full=Solute carrier family 26 member 1;
FUNCTION: High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Expressed most abundantly in the kidney and liver, with lower levels in the pancreas, testis, brain, small intestine, colon, and lung.
SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
SIMILARITY: Contains 1 STAS domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC26A1
Diseases sorted by gene-association score: nephrolithiasis, calcium oxalate* (1380), nephrolithiasis* (444), autosomal dominant nonsyndromic deafness 20 (8), proximal renal tubular acidosis (7)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.58 RPKM in Brain - Cerebellum
Total median expression: 76.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -76.91163-0.472 Picture PostScript Text
3' UTR -541.811176-0.461 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018045 - S04_transporter_CS
IPR002645 - STAS_dom
IPR001902 - SulP_transpt
IPR011547 - Sulph_transpt

Pfam Domains:
PF00916 - Sulfate permease family
PF01740 - STAS domain

SCOP Domains:
52091 - Anti-sigma factor antagonist SpoIIaa

ModBase Predicted Comparative 3D Structure on Q9H2B4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005254 chloride channel activity
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015301 anion:anion antiporter activity
GO:0019531 oxalate transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0008272 sulfate transport
GO:0015701 bicarbonate transport
GO:0019532 oxalate transport
GO:0042391 regulation of membrane potential
GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:0051453 regulation of intracellular pH
GO:0055085 transmembrane transport
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane


-  Descriptions from all associated GenBank mRNAs
  BC015517 - Homo sapiens solute carrier family 26 (sulfate transporter), member 1, mRNA (cDNA clone IMAGE:3885323), complete cds.
KJ893145 - Synthetic construct Homo sapiens clone ccsbBroadEn_02539 SLC26A1 gene, encodes complete protein.
JD305168 - Sequence 286192 from Patent EP1572962.
AY124771 - Homo sapiens sulfate anion tranporter AT1 (SLC26A1) mRNA, complete cds.
JD125867 - Sequence 106891 from Patent EP1572962.
JD118167 - Sequence 99191 from Patent EP1572962.
JD335296 - Sequence 316320 from Patent EP1572962.
JD462762 - Sequence 443786 from Patent EP1572962.
JD336598 - Sequence 317622 from Patent EP1572962.
JD443615 - Sequence 424639 from Patent EP1572962.
JD407910 - Sequence 388934 from Patent EP1572962.
JD199381 - Sequence 180405 from Patent EP1572962.
JD057731 - Sequence 38755 from Patent EP1572962.
JD416083 - Sequence 397107 from Patent EP1572962.
AF297659 - Homo sapiens sulfate/anion transporter SAT-1 protein (SLC26A1) mRNA, complete cds.
JD387529 - Sequence 368553 from Patent EP1572962.
JD383592 - Sequence 364616 from Patent EP1572962.
JD187139 - Sequence 168163 from Patent EP1572962.
JD407386 - Sequence 388410 from Patent EP1572962.
JD289270 - Sequence 270294 from Patent EP1572962.
JD450251 - Sequence 431275 from Patent EP1572962.
JD050522 - Sequence 31546 from Patent EP1572962.
JD320909 - Sequence 301933 from Patent EP1572962.
JD375950 - Sequence 356974 from Patent EP1572962.
JD414579 - Sequence 395603 from Patent EP1572962.
AK292747 - Homo sapiens cDNA FLJ76310 complete cds, highly similar to Homo sapiens solute carrier family 26 (sulfate transporter), member 1 (SLC26A1), transcript variant 1, mRNA.
JD050300 - Sequence 31324 from Patent EP1572962.
JD075665 - Sequence 56689 from Patent EP1572962.
JD259765 - Sequence 240789 from Patent EP1572962.
JD399593 - Sequence 380617 from Patent EP1572962.
JD192143 - Sequence 173167 from Patent EP1572962.
JD270956 - Sequence 251980 from Patent EP1572962.
JD416524 - Sequence 397548 from Patent EP1572962.
JD098791 - Sequence 79815 from Patent EP1572962.
JD137995 - Sequence 119019 from Patent EP1572962.
JD061885 - Sequence 42909 from Patent EP1572962.
JD102392 - Sequence 83416 from Patent EP1572962.
JD102391 - Sequence 83415 from Patent EP1572962.
JD423868 - Sequence 404892 from Patent EP1572962.
JD361352 - Sequence 342376 from Patent EP1572962.
JD070762 - Sequence 51786 from Patent EP1572962.
JD383123 - Sequence 364147 from Patent EP1572962.
JD456906 - Sequence 437930 from Patent EP1572962.
BC157108 - Synthetic construct Homo sapiens clone IMAGE:100063412, MGC:190774 solute carrier family 26 (sulfate transporter), member 1 (SLC26A1) mRNA, encodes complete protein.
BC156322 - Synthetic construct Homo sapiens clone IMAGE:100061815, MGC:190108 solute carrier family 26 (sulfate transporter), member 1 (SLC26A1) mRNA, encodes complete protein.
AB384863 - Synthetic construct DNA, clone: pF1KB3831, Homo sapiens SLC26A1 gene for solute carrier family 26, member 1, complete cds, without stop codon, in Flexi system.
CU677335 - Synthetic construct Homo sapiens gateway clone IMAGE:100016807 5' read SLC26A1 mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H2B4 (Reactome details) participates in the following event(s):

R-HSA-427555 SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol
R-HSA-174362 Transport and synthesis of PAPS
R-HSA-427601 Multifunctional anion exchangers
R-HSA-156584 Cytosolic sulfonation of small molecules
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-425393 Metabolism of nitrogenous molecules
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-71387 Metabolism of carbohydrates
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-211859 Biological oxidations
R-HSA-1430728 Metabolism
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9N2, NM_022042, NP_998778, Q7Z5R3, Q96BK0, Q9H2B4, S26A1_HUMAN, SAT1
UCSC ID: uc003gcc.3
RefSeq Accession: NM_022042
Protein: Q9H2B4 (aka S26A1_HUMAN)
CCDS: CCDS33934.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_022042.2
exon count: 3CDS single in 3' UTR: no RNA size: 3405
ORF size: 2106CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4412.00frame shift in genome: no % Coverage: 99.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.