Human Gene ZSCAN22 (uc002qsc.2) Description and Page Index
  Description: Homo sapiens zinc finger and SCAN domain containing 22 (ZSCAN22), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:58,838,385-58,853,712 Size: 15,328 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr19:58,846,169-58,850,692 Size: 4,524 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:58,838,385-58,853,712)mRNA (may differ from genome)Protein (491 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger and SCAN domain-containing protein 22; AltName: Full=Krueppel-related zinc finger protein 2; AltName: Full=Protein HKR2; AltName: Full=Zinc finger protein 50;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 8 C2H2-type zinc fingers.
SIMILARITY: Contains 1 SCAN box domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.76 RPKM in Pituitary
Total median expression: 57.66 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.00147-0.456 Picture PostScript Text
3' UTR -994.993020-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF02023 - SCAN domain
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on P10073
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  BX537741 - Homo sapiens mRNA; cDNA DKFZp686P21111 (from clone DKFZp686P21111); complete cds.
AK128716 - Homo sapiens cDNA FLJ46883 fis, clone UTERU3016070, weakly similar to Zinc finger protein 29.
BX647879 - Homo sapiens mRNA; cDNA DKFZp313K136 (from clone DKFZp313K136).
BC112277 - Homo sapiens zinc finger and SCAN domain containing 22, mRNA (cDNA clone MGC:138482 IMAGE:8327745), complete cds.
BC101630 - Homo sapiens zinc finger and SCAN domain containing 22, mRNA (cDNA clone MGC:126679 IMAGE:8069136), complete cds.
BC143446 - Homo sapiens cDNA clone IMAGE:9051954.
DQ580560 - Homo sapiens piRNA piR-48672, complete sequence.
AB489169 - Synthetic construct DNA, clone: pF1KB8336, Homo sapiens ZSCAN22 gene for zinc finger and SCAN domain containing 22, without stop codon, in Flexi system.
AM392562 - Synthetic construct Homo sapiens clone IMAGE:100002183 for hypothetical protein (HKR2 gene).
AM393427 - Synthetic construct Homo sapiens clone IMAGE:100002187 for hypothetical protein (HKR2 gene).
HQ258437 - Synthetic construct Homo sapiens clone IMAGE:100072866 zinc finger and SCAN domain containing 22 (ZSCAN22) (ZSCAN22) gene, encodes complete protein.
KJ896092 - Synthetic construct Homo sapiens clone ccsbBroadEn_05486 ZSCAN22 gene, encodes complete protein.
KJ900646 - Synthetic construct Homo sapiens clone ccsbBroadEn_10040 ZSCAN22 gene, encodes complete protein.
DQ600386 - Homo sapiens piRNA piR-38452, complete sequence.
LF379362 - JP 2014500723-A/186865: Polycomb-Associated Non-Coding RNAs.
MA614939 - JP 2018138019-A/186865: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: HKR2, NM_181846, NP_862829, P10073, Q15922, Q7Z3L8, ZNF50, ZSC22_HUMAN
UCSC ID: uc002qsc.2
RefSeq Accession: NM_181846
Protein: P10073 (aka ZSC22_HUMAN)
CCDS: CCDS12975.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_181846.2
exon count: 3CDS single in 3' UTR: no RNA size: 4643
ORF size: 1476CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3152.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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