Human Gene DPCR1 (uc003nsg.2) Description and Page Index
  Description: Homo sapiens diffuse panbronchiolitis critical region 1 (DPCR1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:30,908,777-30,921,998 Size: 13,222 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr6:30,908,777-30,920,894 Size: 12,118 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:30,908,777-30,921,998)mRNA (may differ from genome)Protein (1393 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: E9PEI6_HUMAN
DESCRIPTION: SubName: Full=Diffuse panbronchiolitis critical region protein 1;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DPCR1
CDC HuGE Published Literature: DPCR1
Positive Disease Associations: Behcet Syndrome , HIV-1 control , Lupus Erythematosus, Systemic , Psoriasis , Sodium
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: DPCR1
Diseases sorted by gene-association score: panbronchiolitis, diffuse* (75)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.57 RPKM in Stomach
Total median expression: 45.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -339.361104-0.307 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026623 - DPCR1

ModBase Predicted Comparative 3D Structure on E9PEI6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  JD036364 - Sequence 17388 from Patent EP1572962.
JD365205 - Sequence 346229 from Patent EP1572962.
JD364966 - Sequence 345990 from Patent EP1572962.
JD364966 - Sequence 345990 from Patent EP1572962.
JD435927 - Sequence 416951 from Patent EP1572962.
AL833738 - Homo sapiens mRNA; cDNA DKFZp666O235 (from clone DKFZp666O235).
JD435926 - Sequence 416950 from Patent EP1572962.
EU831848 - Synthetic construct Homo sapiens clone HAIB:100066877; DKFZo004C0222 diffuse panbronchiolitis critical region 1 protein (DPCR1) gene, encodes complete protein.
EU831770 - Synthetic construct Homo sapiens clone HAIB:100066799; DKFZo008C0221 diffuse panbronchiolitis critical region 1 protein (DPCR1) gene, encodes complete protein.
BC101661 - Homo sapiens diffuse panbronchiolitis critical region 1, mRNA (cDNA clone MGC:126710 IMAGE:8069167), complete cds.
BC101663 - Homo sapiens diffuse panbronchiolitis critical region 1, mRNA (cDNA clone MGC:126712 IMAGE:8069169), complete cds.
AB064272 - Homo sapiens mRNA for DPCR1, complete cds.
CU686838 - Synthetic construct Homo sapiens gateway clone IMAGE:100022611 5' read DPCR1 mRNA.
HQ448413 - Synthetic construct Homo sapiens clone IMAGE:100071840; CCSB013893_01 diffuse panbronchiolitis critical region 1 (DPCR1) gene, encodes complete protein.
KJ903791 - Synthetic construct Homo sapiens clone ccsbBroadEn_13185 DPCR1 gene, encodes complete protein.
BC069477 - Homo sapiens diffuse panbronchiolitis critical region 1, mRNA (cDNA clone MGC:97049 IMAGE:7262259), complete cds.
JD209334 - Sequence 190358 from Patent EP1572962.
JD076262 - Sequence 57286 from Patent EP1572962.
JD104776 - Sequence 85800 from Patent EP1572962.
JD173830 - Sequence 154854 from Patent EP1572962.
JD430054 - Sequence 411078 from Patent EP1572962.
JD557168 - Sequence 538192 from Patent EP1572962.
JD483719 - Sequence 464743 from Patent EP1572962.
JD473119 - Sequence 454143 from Patent EP1572962.
JD114458 - Sequence 95482 from Patent EP1572962.
JD265581 - Sequence 246605 from Patent EP1572962.
JD296470 - Sequence 277494 from Patent EP1572962.
JD236889 - Sequence 217913 from Patent EP1572962.
JD490616 - Sequence 471640 from Patent EP1572962.
JD463701 - Sequence 444725 from Patent EP1572962.
JD043480 - Sequence 24504 from Patent EP1572962.
JD556057 - Sequence 537081 from Patent EP1572962.
JD234441 - Sequence 215465 from Patent EP1572962.
JD524625 - Sequence 505649 from Patent EP1572962.
JD499103 - Sequence 480127 from Patent EP1572962.
JD161252 - Sequence 142276 from Patent EP1572962.
JD297853 - Sequence 278877 from Patent EP1572962.
JD254152 - Sequence 235176 from Patent EP1572962.
JD249318 - Sequence 230342 from Patent EP1572962.
JD225008 - Sequence 206032 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PEI6, E9PEI6_HUMAN, NM_080870, NP_543146
UCSC ID: uc003nsg.2
RefSeq Accession: NM_080870
Protein: E9PEI6 CCDS: CCDS4692.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_080870.3
exon count: 3CDS single in 3' UTR: no RNA size: 5306
ORF size: 4182CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6635.00frame shift in genome: no % Coverage: 99.62
has start codon: yes stop codon in genome: no # of Alignments: 5
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.