Human Gene ANXA10 (uc003irm.3) Description and Page Index
  Description: Homo sapiens annexin A10 (ANXA10), mRNA.
RefSeq Summary (NM_007193): This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007320.2, AF196478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr4:169,013,688-169,108,893 Size: 95,206 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr4:169,013,852-169,108,585 Size: 94,734 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:169,013,688-169,108,893)mRNA (may differ from genome)Protein (324 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Annexin A10; AltName: Full=Annexin-10; AltName: Full=Annexin-14;
SIMILARITY: Belongs to the annexin family.
SIMILARITY: Contains 4 annexin repeats.

-  MalaCards Disease Associations
  MalaCards Gene Search: ANXA10
Diseases sorted by gene-association score: lynch syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 159.12 RPKM in Stomach
Total median expression: 186.76 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.74164-0.175 Picture PostScript Text
3' UTR -49.30308-0.160 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001464 - Annexin
IPR018502 - Annexin_repeat
IPR018252 - Annexin_repeat_CS
IPR008156 - AnnexinX

Pfam Domains:
PF00191 - Annexin

SCOP Domains:
47874 - Annexin

ModBase Predicted Comparative 3D Structure on Q9UJ72
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding

-  Descriptions from all associated GenBank mRNAs
  BC007320 - Homo sapiens annexin A10, mRNA (cDNA clone MGC:1303 IMAGE:2988009), complete cds.
AF196478 - Homo sapiens annexin 14 (ANX14) mRNA, complete cds.
AJ238979 - Homo sapiens mRNA for annexin A10 protein (ANXA10 gene).
CU675613 - Synthetic construct Homo sapiens gateway clone IMAGE:100018936 5' read ANXA10 mRNA.
EU176730 - Synthetic construct Homo sapiens clone IMAGE:100011666; FLH264099.01L; RZPDo839H08257D annexin A10 (ANXA10) gene, encodes complete protein.
KJ893252 - Synthetic construct Homo sapiens clone ccsbBroadEn_02646 ANXA10 gene, encodes complete protein.
JD488633 - Sequence 469657 from Patent EP1572962.
JD375540 - Sequence 356564 from Patent EP1572962.
AY626137 - Homo sapiens putative annexin A10 short isoform mRNA, complete cds.
JD231328 - Sequence 212352 from Patent EP1572962.
JD354659 - Sequence 335683 from Patent EP1572962.
JD306185 - Sequence 287209 from Patent EP1572962.
JD358894 - Sequence 339918 from Patent EP1572962.
JD293732 - Sequence 274756 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ANX10_HUMAN, ANX14, NM_007193, NP_009124, Q96IQ5, Q9UJ72, Q9UJV4
UCSC ID: uc003irm.3
RefSeq Accession: NM_007193
Protein: Q9UJ72 (aka ANX10_HUMAN or ANXA_HUMAN)
CCDS: CCDS34096.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_007193.4
exon count: 12CDS single in 3' UTR: no RNA size: 1447
ORF size: 975CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2135.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.