Human Gene RPS17 (uc002bio.1)
  Description: Homo sapiens ribosomal protein S17-like (RPS17), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:83,205,504-83,209,208 Size: 3,705 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr15:83,205,552-83,209,179 Size: 3,628 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:83,205,504-83,209,208)mRNA (may differ from genome)Protein (135 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsH-INV
HGNCLynxMalacardsMGIneXtProtPubMed
TreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: RS17L_HUMAN
DESCRIPTION: RecName: Full=40S ribosomal protein S17-like;
SIMILARITY: Belongs to the ribosomal protein S17e family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RPS17
CDC HuGE Published Literature: RPS17

-  MalaCards Disease Associations
  MalaCards Gene Search: RPS17
Diseases sorted by gene-association score: diamond-blackfan anemia 4* (930), rps17-related diamond-blackfan anemia* (500), diamond-blackfan anemia* (183), congenital hypoplastic anemia (25), diaphragm disease (18), macrocytic anemia (16), retinitis pigmentosa 49 (15), immune system disease (15), corneal fleck dystrophy (14), stromal dystrophy (11), hepatitis e (11), pure red-cell aplasia (10), necrotizing fasciitis (9), pierre robin syndrome (8), bone deterioration disease (6), physical disorder (6), fasciitis (6), aplastic anemia (2)
* = Manually curated disease association

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.07 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.7029-0.093 Picture PostScript Text
3' UTR -5.2048-0.108 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001210 - Ribosomal_S17e
IPR018273 - Ribosomal_S17e_CS

Pfam Domains:
PF00833 - Ribosomal S17

ModBase Predicted Comparative 3D Structure on P0CW22
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsemblFlyBaseWormBaseSGD
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
 AlignmentAlignmentAlignmentAlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  BC009407 - Homo sapiens ribosomal protein S17, mRNA (cDNA clone MGC:19553 IMAGE:4334552), complete cds.
BC070222 - Homo sapiens ribosomal protein S17, mRNA (cDNA clone MGC:88203 IMAGE:6738383), complete cds.
BC071928 - Homo sapiens ribosomal protein S17, mRNA (cDNA clone MGC:88613 IMAGE:5090053), complete cds.
BC049824 - Homo sapiens ribosomal protein S17, mRNA (cDNA clone MGC:59704 IMAGE:6212543), complete cds.
BC020453 - Homo sapiens ribosomal protein S17, mRNA (cDNA clone IMAGE:3450232).
BC019899 - Homo sapiens ribosomal protein S17, mRNA (cDNA clone MGC:29933 IMAGE:3882924), complete cds.
AK026570 - Homo sapiens cDNA: FLJ22917 fis, clone KAT06430.
BC062715 - Homo sapiens ribosomal protein S17, mRNA (cDNA clone MGC:72007 IMAGE:4068842), complete cds.
M13932 - Human ribosomal protein S17 mRNA, complete cds.
BC022370 - Homo sapiens ribosomal protein S17, mRNA (cDNA clone MGC:23905 IMAGE:4738331), complete cds.
AK311951 - Homo sapiens cDNA, FLJ92219, Homo sapiens ribosomal protein S17 (RPS17), mRNA.
KJ897506 - Synthetic construct Homo sapiens clone ccsbBroadEn_06900 RPS17 gene, encodes complete protein.
CU687068 - Synthetic construct Homo sapiens gateway clone IMAGE:100023030 5' read RPS17 mRNA.
KJ905912 - Synthetic construct Homo sapiens clone ccsbBroadEn_15582 RPS17 gene, encodes complete protein.
DQ893380 - Synthetic construct clone IMAGE:100006010; FLH199452.01X; RZPDo839A0882D ribosomal protein S17 (RPS17) gene, encodes complete protein.
DQ896701 - Synthetic construct Homo sapiens clone IMAGE:100011161; FLH199358.01L; RZPDo839A0881D ribosomal protein S17 (RPS17) gene, encodes complete protein.
DQ582527 - Homo sapiens piRNA piR-32639, complete sequence.
AB055777 - Homo sapiens mRNA for ribosomal protein S17, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001199057, NP_001185986, P0CW22, RPS17L, RS17L_HUMAN
UCSC ID: uc002bio.1
RefSeq Accession: NM_001199057
Protein: P0CW22 (aka RS17L_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene RPS17:
diamond-b (Diamond-Blackfan Anemia)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001199057.1
exon count: 5CDS single in 3' UTR: no RNA size: 485
ORF size: 408CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1016.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.