Human Gene ATP4B (uc001vtz.3)
  Description: Homo sapiens ATPase, H+/K+ exchanging, beta polypeptide (ATP4B), mRNA.
RefSeq Summary (NM_000705): The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr13:114,303,122-114,312,513 Size: 9,392 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr13:114,303,689-114,312,459 Size: 8,771 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:114,303,122-114,312,513)mRNA (may differ from genome)Protein (291 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ATP4B_HUMAN
DESCRIPTION: RecName: Full=Potassium-transporting ATPase subunit beta; AltName: Full=Gastric H(+)/K(+) ATPase subunit beta; AltName: Full=Proton pump beta chain;
SUBUNIT: Composed of two subunits: alpha (catalytic) and beta.
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ATP4B
CDC HuGE Published Literature: ATP4B
Positive Disease Associations: Bipolar Disorder , monocyte chemoattractant protein 1 (66-77)
Related Studies:
  1. Bipolar Disorder
    , , . [PubMed 0]
  2. monocyte chemoattractant protein 1 (66-77)
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 680.20 RPKM in Stomach
Total median expression: 683.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.6054-0.307 Picture PostScript Text
3' UTR -132.92567-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000402 - ATPase_P-typ_cation-exchng_bsu

Pfam Domains:
PF00287 - Sodium / potassium ATPase beta chain

ModBase Predicted Comparative 3D Structure on P51164
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008900 hydrogen:potassium-exchanging ATPase activity

Biological Process:
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0007155 cell adhesion
GO:0010243 response to organonitrogen compound
GO:0032496 response to lipopolysaccharide
GO:1902600 hydrogen ion transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  M75110 - Human H,K-ATPase beta subunit mRNA, complete cds.
BC029059 - Homo sapiens ATPase, H+/K+ exchanging, beta polypeptide, mRNA (cDNA clone MGC:34515 IMAGE:5186859), complete cds.
JD278572 - Sequence 259596 from Patent EP1572962.
KJ896473 - Synthetic construct Homo sapiens clone ccsbBroadEn_05867 ATP4B gene, encodes complete protein.
DQ890817 - Synthetic construct clone IMAGE:100003447; FLH166188.01X; RZPDo839D1086D ATPase, H+/K+ exchanging, beta polypeptide (ATP4B) gene, encodes complete protein.
DQ893973 - Synthetic construct Homo sapiens clone IMAGE:100008433; FLH166184.01L; RZPDo839D1085D ATPase, H+/K+ exchanging, beta polypeptide (ATP4B) gene, encodes complete protein.
CU688596 - Synthetic construct Homo sapiens gateway clone IMAGE:100016979 5' read ATP4B mRNA.
AK310129 - Homo sapiens cDNA, FLJ17171.
BC042846 - Homo sapiens ATPase, H+/K+ exchanging, beta polypeptide, mRNA (cDNA clone IMAGE:5189398), partial cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation
hsa04966 - Collecting duct acid secretion

Reactome (by CSHL, EBI, and GO)

Protein P51164 (Reactome details) participates in the following event(s):

R-HSA-937311 ATP4A/12A:ATP4B exchanges K+ for H+
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-983712 Ion channel transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: ATP4B_HUMAN, B1B0N8, NM_000705, NP_000696, P51164
UCSC ID: uc001vtz.3
RefSeq Accession: NM_000705
Protein: P51164 (aka ATP4B_HUMAN or ATHB_HUMAN)
CCDS: CCDS9539.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_000705.3
exon count: 7CDS single in 3' UTR: no RNA size: 1509
ORF size: 876CDS single in intron: no Alignment % ID: 99.93
txCdsPredict score: 1952.00frame shift in genome: no % Coverage: 99.20
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.