Human Gene TMEM14C (uc021ylj.1) Description and Page Index
  Description: Homo sapiens transmembrane protein 14C (TMEM14C), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:10,723,148-10,731,362 Size: 8,215 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr6:10,724,847-10,730,899 Size: 6,053 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:10,723,148-10,731,362)mRNA (may differ from genome)Protein (112 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCHPRDLynxMGIneXtProtOMIM
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TM14C_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 14C;
FUNCTION: Required for normal heme biosynthesis (By similarity).
SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the UPF0136 (TMEM14) family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM14C
CDC HuGE Published Literature: TMEM14C

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 87.92 RPKM in Adrenal Gland
Total median expression: 2548.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -153.90385-0.400 Picture PostScript Text
3' UTR -107.21463-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005349 - UPF0136_TM

Pfam Domains:
PF03647 - Transmembrane proteins 14C

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2LOS
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9P0S9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsemblFlyBase  
 Protein SequenceProtein SequenceProtein Sequence  
 AlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006783 heme biosynthetic process

Cellular Component:
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane


-  Descriptions from all associated GenBank mRNAs
  KJ893930 - Synthetic construct Homo sapiens clone ccsbBroadEn_03324 TMEM14C gene, encodes complete protein.
AF151028 - Homo sapiens HSPC194 mRNA, complete cds.
JD103987 - Sequence 85011 from Patent EP1572962.
BC010086 - Homo sapiens transmembrane protein 14C, mRNA (cDNA clone MGC:19642 IMAGE:2907072), complete cds.
AK310191 - Homo sapiens cDNA, FLJ17233.
AK309591 - Homo sapiens cDNA, FLJ99632.
AF164962 - Homo sapiens MSTP073 mRNA, complete cds.
BC002496 - Homo sapiens transmembrane protein 14C, mRNA (cDNA clone MGC:889 IMAGE:3050609), complete cds.
AK223462 - Homo sapiens mRNA for transmembrane protein 14C variant, clone: FCC116H07.
JD157675 - Sequence 138699 from Patent EP1572962.
JD316864 - Sequence 297888 from Patent EP1572962.
DQ895777 - Synthetic construct Homo sapiens clone IMAGE:100010237; FLH187531.01L; RZPDo839A06149D transmembrane protein 14C (TMEM14C) gene, encodes complete protein.
DQ892562 - Synthetic construct clone IMAGE:100005192; FLH187535.01X; RZPDo839A06150D transmembrane protein 14C (TMEM14C) gene, encodes complete protein.
JD316648 - Sequence 297672 from Patent EP1572962.
JD236780 - Sequence 217804 from Patent EP1572962.
JD511983 - Sequence 493007 from Patent EP1572962.
JD492606 - Sequence 473630 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf53, HSPC194, NM_001165258, NP_057546, Q5T4I6, Q9P0S9, TM14C_HUMAN
UCSC ID: uc021ylj.1
RefSeq Accession: NM_001165258
Protein: Q9P0S9 (aka TM14C_HUMAN or T14C_HUMAN)
CCDS: CCDS4514.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001165258.1
exon count: 6CDS single in 3' UTR: no RNA size: 1201
ORF size: 339CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 718.50frame shift in genome: no % Coverage: 98.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.