Human Gene RPS19BP1 (uc003ayb.3) Description and Page Index
  Description: Homo sapiens ribosomal protein S19 binding protein 1 (RPS19BP1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr22:39,925,098-39,928,860 Size: 3,763 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr22:39,925,497-39,928,743 Size: 3,247 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr22:39,925,098-39,928,860)mRNA (may differ from genome)Protein (136 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Active regulator of SIRT1; AltName: Full=40S ribosomal protein S19-binding protein 1; Short=RPS19-binding protein 1; Short=S19BP;
FUNCTION: Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.
SUBUNIT: Interacts with RPS19 (By similarity). Interacts with SIRT1.
INTERACTION: Q96EB6:SIRT1; NbExp=9; IntAct=EBI-4479407, EBI-1802965;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
TISSUE SPECIFICITY: Widely expressed (at protein level).
SIMILARITY: Belongs to the AROS family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 73.12 RPKM in Prostate
Total median expression: 2725.63 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.60117-0.424 Picture PostScript Text
3' UTR -174.30399-0.437 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023262 - Active_regulator_of_SIRT1

Pfam Domains:
PF15684 - Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1

ModBase Predicted Comparative 3D Structure on Q86WX3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  BC037573 - Homo sapiens ribosomal protein S19 binding protein 1, mRNA (cDNA clone MGC:45448 IMAGE:5399759), complete cds.
BC047711 - Homo sapiens ribosomal protein S19 binding protein 1, mRNA (cDNA clone MGC:52010 IMAGE:6064917), complete cds.
AK025423 - Homo sapiens cDNA: FLJ21770 fis, clone COLF7654.
AK055865 - Homo sapiens cDNA FLJ31303 fis, clone LIVER1000082.
CR456443 - Homo sapiens dJ1104E15.4 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ1104E15.4).
JD118491 - Sequence 99515 from Patent EP1572962.
JD149631 - Sequence 130655 from Patent EP1572962.
JD371458 - Sequence 352482 from Patent EP1572962.
JD460285 - Sequence 441309 from Patent EP1572962.
JD535460 - Sequence 516484 from Patent EP1572962.
JD310245 - Sequence 291269 from Patent EP1572962.
JD361426 - Sequence 342450 from Patent EP1572962.
JD436412 - Sequence 417436 from Patent EP1572962.
JD371159 - Sequence 352183 from Patent EP1572962.
CU013041 - Homo sapiens RPS19BP1, mRNA (cDNA clone IMAGE:100000299), complete cds, with stop codon, in Gateway system.
KJ895156 - Synthetic construct Homo sapiens clone ccsbBroadEn_04550 RPS19BP1 gene, encodes complete protein.
CU013329 - Homo sapiens RPS19BP1, mRNA (cDNA clone IMAGE:100000203), complete cds, without stop codon, in Gateway system.
DL492020 - Novel nucleic acids.
DL490572 - Novel nucleic acids.
JD374051 - Sequence 355075 from Patent EP1572962.
JD394758 - Sequence 375782 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AROS, AROS_HUMAN, B0QY96, NM_194326, NP_919307, Q5JZA1, Q86WX3
UCSC ID: uc003ayb.3
RefSeq Accession: NM_194326
Protein: Q86WX3 (aka AROS_HUMAN)
CCDS: CCDS13997.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_194326.2
exon count: 4CDS single in 3' UTR: no RNA size: 952
ORF size: 411CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1022.00frame shift in genome: no % Coverage: 97.37
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.