ID:AROS_HUMAN DESCRIPTION: RecName: Full=Active regulator of SIRT1; AltName: Full=40S ribosomal protein S19-binding protein 1; Short=RPS19-binding protein 1; Short=S19BP; FUNCTION: Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. SUBUNIT: Interacts with RPS19 (By similarity). Interacts with SIRT1. INTERACTION: Q96EB6:SIRT1; NbExp=9; IntAct=EBI-4479407, EBI-1802965; SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Widely expressed (at protein level). SIMILARITY: Belongs to the AROS family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF15684 - Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
ModBase Predicted Comparative 3D Structure on Q86WX3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.