Human Gene SNX17 (uc002rkg.2) Description and Page Index
Description: Homo sapiens sorting nexin 17 (SNX17), transcript variant 1, mRNA. RefSeq Summary (NM_014748): This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]. Transcript (Including UTRs) Position: hg19 chr2:27,593,363-27,600,400 Size: 7,038 Total Exon Count: 15 Strand: + Coding Region Position: hg19 chr2:27,593,611-27,599,586 Size: 5,976 Coding Exon Count: 15
ID:SNX17_HUMAN DESCRIPTION: RecName: Full=Sorting nexin-17; FUNCTION: May be involved in several stages of intracellular protein trafficking. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)). SUBUNIT: Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). INTERACTION: P16333:NCK1; NbExp=3; IntAct=EBI-1752620, EBI-389883; P19174:PLCG1; NbExp=2; IntAct=EBI-1752620, EBI-79387; SUBCELLULAR LOCATION: Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. DOMAIN: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes. SIMILARITY: Belongs to the sorting nexin family. SIMILARITY: Contains 1 PX (phox homology) domain. SIMILARITY: Contains 1 Ras-associating domain. SEQUENCE CAUTION: Sequence=BAA06542.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15036
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.