Human Gene ANXA7 (uc001jtz.2) Description and Page Index
Description: Homo sapiens annexin A7 (ANXA7), transcript variant 2, mRNA. RefSeq Summary (NM_004034): Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr10:75,135,189-75,173,841 Size: 38,653 Total Exon Count: 14 Strand: - Coding Region Position: hg19 chr10:75,135,853-75,160,614 Size: 24,762 Coding Exon Count: 13
ID:ANXA7_HUMAN DESCRIPTION: RecName: Full=Annexin A7; AltName: Full=Annexin VII; AltName: Full=Annexin-7; AltName: Full=Synexin; FUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. SUBUNIT: Interacts with PDCD6. TISSUE SPECIFICITY: Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid. SIMILARITY: Belongs to the annexin family. SIMILARITY: Contains 4 annexin repeats. SEQUENCE CAUTION: Sequence=CAI52483.1; Type=Erroneous gene model prediction;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ANXA7 CDC HuGE Published Literature: ANXA7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20073
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.