Description: Homo sapiens nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1), mRNA. RefSeq Summary (NM_022731): This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr1:205,681,947-205,719,372 Size: 37,426 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr1:205,687,408-205,719,101 Size: 31,694 Coding Exon Count: 7
ID:NUCKS_HUMAN DESCRIPTION: RecName: Full=Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1; AltName: Full=P1; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung. PTM: Phosphorylated by CDK1 and casein kinase. Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE CAUTION: Sequence=BAB15076.1; Type=Erroneous termination; Positions=164; Note=Translated as Arg; Sequence=CAC20412.1; Type=Erroneous gene model prediction;
Cystatins Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics.
[PubMed 17903292]
Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
Glucose James B Meigs et al. BMC medical genetics 2007, Genome-wide association with diabetes-related traits in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903298]
Framingham 100K SNP data is a resource for association tests of known and novel genes with diabetes and related traits posted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007 webcite. Framingham 100K data replicate the TCF7L2 association with diabetes.
Mental Competency Kathryn L Lunetta et al. BMC medical genetics 2007, Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study., BMC medical genetics.
[PubMed 17903295]
Longevity and aging traits are associated with SNPs on the Affymetrix 100K GeneChip. None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H1E3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003682 chromatin binding GO:0003690 double-stranded DNA binding GO:0003697 single-stranded DNA binding GO:0003723 RNA binding GO:0008134 transcription factor binding
Biological Process: GO:0000724 double-strand break repair via homologous recombination GO:0001678 cellular glucose homeostasis GO:0006275 regulation of DNA replication GO:0006325 chromatin organization GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0019046 release from viral latency GO:0031297 replication fork processing GO:0035822 gene conversion GO:0036297 interstrand cross-link repair GO:0042593 glucose homeostasis GO:0043923 positive regulation by host of viral transcription GO:0044829 positive regulation by host of viral genome replication GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046626 regulation of insulin receptor signaling pathway GO:0046628 positive regulation of insulin receptor signaling pathway GO:0060382 regulation of DNA strand elongation GO:0071481 cellular response to X-ray GO:1990968 modulation by host of RNA binding by virus GO:1990969 modulation by host of viral RNA-binding transcription factor activity