Human Gene C1orf43 (uc001fei.2) Description and Page Index
Description: Homo sapiens chromosome 1 open reading frame 43 (C1orf43), transcript variant 3, mRNA.
Transcript (Including UTRs)
Position: hg19 chr1:154,179,183-154,193,273 Size: 14,091 Total Exon Count: 7 Strand: -
Position: hg19 chr1:154,179,929-154,192,883 Size: 12,955 Coding Exon Count: 7
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Uncharacterized protein C1orf43; AltName: Full=Hepatitis C virus NS5A-transactivated protein 4; Short=HCV NS5A-transactivated protein 4; AltName: Full=Protein NICE-3; AltName: Full=S863-3;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). SEQUENCE CAUTION: Sequence=CAH71276.1; Type=Erroneous gene model prediction;
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR013328 - DH_multihelical
IPR010876 - NICE-3_prd
Pfam Domains: PF07406 - NICE-3 protein
ModBase Predicted Comparative 3D Structure on Q9BWL3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AF109185 - Homo sapiens S863-3 mRNA, complete cds. BC001377 - Homo sapiens chromosome 1 open reading frame 43, mRNA (cDNA clone MGC:1147 IMAGE:3051048), complete cds. AF077036 - Homo sapiens HSPC012 mRNA, complete cds. AJ243665 - Homo sapiens partial mRNA for NICE-3 protein, clone 3038j13. BC014391 - Homo sapiens chromosome 1 open reading frame 43, mRNA (cDNA clone MGC:1148 IMAGE:3544590), complete cds. AJ243664 - Homo sapiens mRNA for NICE-3 protein, clone 3038m19. BC000152 - Homo sapiens chromosome 1 open reading frame 43, mRNA (cDNA clone MGC:5332 IMAGE:2901006), complete cds. AL117463 - Homo sapiens mRNA; cDNA DKFZp586G1722 (from clone DKFZp586G1722). AJ243663 - Homo sapiens mRNA for NICE-3 protein, clone 1023j12. BC006514 - Homo sapiens chromosome 1 open reading frame 43, mRNA (cDNA clone MGC:2729 IMAGE:2822327), complete cds. E08543 - cDNA encoding novel protein produced by glioblastoma. BC088353 - Homo sapiens chromosome 1 open reading frame 43, mRNA (cDNA clone MGC:111001 IMAGE:6164281), complete cds. JD206944 - Sequence 187968 from Patent EP1572962. JD020784 - Sequence 1808 from Patent EP1572962. JD531784 - Sequence 512808 from Patent EP1572962. JD314911 - Sequence 295935 from Patent EP1572962. JD033260 - Sequence 14284 from Patent EP1572962. JD519958 - Sequence 500982 from Patent EP1572962. JD048337 - Sequence 29361 from Patent EP1572962. JD339333 - Sequence 320357 from Patent EP1572962. AF529365 - Homo sapiens NS5ATP4 (NS5ATP4) mRNA, complete cds. DQ908899 - Homo sapiens NS5ATP4A (NS5ATP4A) mRNA, complete cds. CU674064 - Synthetic construct Homo sapiens gateway clone IMAGE:100016900 5' read C1orf43 mRNA. HQ447133 - Synthetic construct Homo sapiens clone IMAGE:100070421; CCSB000047_01 chromosome 1 open reading frame 43 (C1orf43) gene, encodes complete protein. KJ893489 - Synthetic construct Homo sapiens clone ccsbBroadEn_02883 C1orf43 gene, encodes complete protein. E08542 - cDNA encoding novel protein produced by glioblastoma. CR457131 - Homo sapiens full open reading frame cDNA clone RZPDo834H117D for gene NICE-3, NICE-3 protein; complete cds, incl. stopcodon. AK093707 - Homo sapiens cDNA FLJ36388 fis, clone THYMU2008910. AK290583 - Homo sapiens cDNA FLJ77067 complete cds. BC008306 - Homo sapiens chromosome 1 open reading frame 43, mRNA (cDNA clone MGC:15205 IMAGE:3502049), complete cds. KJ902389 - Synthetic construct Homo sapiens clone ccsbBroadEn_11783 C1orf43 gene, encodes complete protein. CU678913 - Synthetic construct Homo sapiens gateway clone IMAGE:100018002 5' read C1orf43 mRNA. JD039495 - Sequence 20519 from Patent EP1572962. JD071692 - Sequence 52716 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A8K3G8, CA043_HUMAN, D3DV72, D3DV74, HSPC012, NICE3, NM_001098616, NP_001092086, NS5ATP4, Q5M801, Q5VU73, Q5VU83, Q96HP7, Q9BWL3, Q9UFU2, Q9UGL7, Q9UGL8, Q9Y2R6 UCSC ID: uc001fei.2 RefSeq Accession: NM_001098616
(aka CA043_HUMAN) Q9BWL3
Gene Model Information
7 CDS single in 3' UTR:
762 CDS single in intron:
Alignment % ID:
1427.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.