Human Gene PSMD4 (uc001exl.3) Description and Page Index
Description: Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (PSMD4), mRNA. RefSeq Summary (NM_002810): The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:151,227,197-151,239,954 Size: 12,758 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr1:151,227,259-151,239,819 Size: 12,561 Coding Exon Count: 10
ID:PSMD4_HUMAN DESCRIPTION: RecName: Full=26S proteasome non-ATPase regulatory subunit 4; AltName: Full=26S proteasome regulatory subunit RPN10; AltName: Full=26S proteasome regulatory subunit S5A; AltName: Full=Antisecretory factor 1; Short=AF; Short=ASF; AltName: Full=Multiubiquitin chain-binding protein; FUNCTION: Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion. SUBUNIT: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Directly interacts with NUB1. Interacts with SQSTM1. Interacts with UBQLN4. Interacts with UBE3A. INTERACTION: P24610:Pax3 (xeno); NbExp=3; IntAct=EBI-359318, EBI-1208116; P54725:RAD23A; NbExp=2; IntAct=EBI-359318, EBI-746453; P54727:RAD23B; NbExp=5; IntAct=EBI-359318, EBI-954531; Q9P0W5:SCHIP1; NbExp=2; IntAct=EBI-359318, EBI-1397509; DOMAIN: The 2 UIM motifs are involved in the binding to a multi- ubiquitin chain in a cooperative way. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the proteasome subunit S5A family. SIMILARITY: Contains 2 UIM (ubiquitin-interacting motif) repeats. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55036
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0016579 protein deubiquitination GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043248 proteasome assembly GO:0043687 post-translational protein modification