Human Gene ANP32C (uc011cjk.2) Description and Page Index
  Description: Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member C (ANP32C), mRNA.
RefSeq Summary (NM_012403): Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr4:165,118,159-165,118,863 Size: 705 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr4:165,118,159-165,118,863 Size: 705 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:165,118,159-165,118,863)mRNA (may differ from genome)Protein (234 aa)
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HGNCHPRDLynxMGIneXtProtOMIM
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: AN32C_HUMAN
DESCRIPTION: RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member C; AltName: Full=Phosphoprotein 32-related protein 1; AltName: Full=Tumorigenic protein pp32r1;
TISSUE SPECIFICITY: Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal prostatic tissue.
SIMILARITY: Belongs to the ANP32 family.
SIMILARITY: Contains 4 LRR (leucine-rich) repeats.
CAUTION: The His-140 polymorphism is uncertain. It has been found in prostatic cell line without corresponding normal tissue sample. Cells transfected with this variant expressed at least twice as much proteins than native cells.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ANP32C
CDC HuGE Published Literature: ANP32C
Positive Disease Associations: Albumins , Blood Cells , Body Fat Distribution , Exercise Test , Hemoglobins , Respiratory Function Tests
Related Studies:
  1. Albumins
    , , . [PubMed 0]
  2. Blood Cells
    Qiong Yang et al. BMC medical genetics 2007, Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903294]
    Using genome-wide association methodology, we have successfully identified a SNP in complete LD with a sequence variant previously shown to be strongly associated with factor VII, providing proof of principle for this approach. Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes.
  3. Body Fat Distribution
    , , . [PubMed 0]
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.04 RPKM in Brain - Caudate (basal ganglia)
Total median expression: 0.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR025875 - Leu-rich_rpt_2_copies

Pfam Domains:
PF00560 - Leucine Rich Repeat
PF12799 - Leucine Rich repeats (2 copies)
PF13516 - Leucine Rich repeat
PF14580 - Leucine-rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on O43423
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0042393 histone binding

Biological Process:
GO:0006913 nucleocytoplasmic transport
GO:0042981 regulation of apoptotic process
GO:0006334 nucleosome assembly
GO:0043486 histone exchange

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LP896342 - Sequence 1206 from Patent EP3253886.
BC172312 - Synthetic construct Homo sapiens clone IMAGE:100069006, MGC:199017 acidic (leucine-rich) nuclear phosphoprotein 32 family, member C (ANP32C) mRNA, encodes complete protein.
JD435978 - Sequence 417002 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AN32C_HUMAN, NM_012403, NP_036535, O43423, PP32R1, Q4W5F9
UCSC ID: uc011cjk.2
RefSeq Accession: NM_012403
Protein: O43423 (aka AN32C_HUMAN or A32C_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_012403.1
exon count: 1CDS single in 3' UTR: no RNA size: 705
ORF size: 705CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 967.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.