Human Gene HIST1H3I (uc003njy.3) Description and Page Index
  Description: Homo sapiens histone cluster 1, H3i (HIST1H3I), mRNA.
RefSeq Summary (NM_003533): Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC066884.1, CF272030.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr6:27,839,623-27,840,099 Size: 477 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr6:27,839,683-27,840,093 Size: 411 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:27,839,623-27,840,099)mRNA (may differ from genome)Protein (136 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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HGNCHPRDLynxMGIneXtProtOMIM
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: H31_HUMAN
DESCRIPTION: RecName: Full=Histone H3.1; AltName: Full=Histone H3/a; AltName: Full=Histone H3/b; AltName: Full=Histone H3/c; AltName: Full=Histone H3/d; AltName: Full=Histone H3/f; AltName: Full=Histone H3/h; AltName: Full=Histone H3/i; AltName: Full=Histone H3/j; AltName: Full=Histone H3/k; AltName: Full=Histone H3/l;
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
INTERACTION: P38991:IPL1 (xeno); NbExp=2; IntAct=EBI-79722, EBI-9319; Q03164:MLL; NbExp=10; IntAct=EBI-79722, EBI-591370; Q8WTS6:SETD7; NbExp=4; IntAct=EBI-79722, EBI-1268586;
SUBCELLULAR LOCATION: Nucleus. Chromosome.
DEVELOPMENTAL STAGE: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
PTM: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).
PTM: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
PTM: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
PTM: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double- strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
PTM: Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin- associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.
PTM: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
PTM: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (PubMed:22483618).
PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
MISCELLANEOUS: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
SIMILARITY: Belongs to the histone H3 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: HIST1H3I
Diseases sorted by gene-association score: corneal dystrophy, posterior polymorphous, 1 (2), brain stem cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -8.9060-0.148 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009072 - Histone-fold
IPR007125 - Histone_core_D
IPR000164 - Histone_H3

Pfam Domains:
PF00125 - Core histone H2A/H2B/H3/H4

SCOP Domains:
47113 - Histone-fold

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1CS9
- NMR

1CT6
- NMR

1Q3L
- X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
2B2T - X-ray MuPIT 2B2U - X-ray MuPIT 2B2V - X-ray MuPIT
2B2W - X-ray MuPIT 2C1J - X-ray MuPIT 2C1N - X-ray MuPIT
2CV5 - X-ray MuPIT 2L75 - NMR MuPIT 2LBM - NMR MuPIT
2RI7 - X-ray MuPIT 2UXN - X-ray MuPIT 3A1B - X-ray MuPIT
3AFA - X-ray MuPIT 3AVR - X-ray MuPIT 3AYW - X-ray MuPIT
3AZE - X-ray MuPIT 3AZF - X-ray MuPIT 3AZG - X-ray MuPIT
3AZH - X-ray MuPIT 3AZI - X-ray MuPIT 3AZJ - X-ray MuPIT
3AZK - X-ray MuPIT 3AZL - X-ray MuPIT 3AZM - X-ray MuPIT
3AZN - X-ray MuPIT 3B95 - X-ray MuPIT 3KMT - X-ray
3O34 - X-ray MuPIT 3O35 - X-ray MuPIT 3O37 - X-ray MuPIT
3RIG - X-ray MuPIT 3RIY - X-ray MuPIT 3U4S - X-ray MuPIT
3U5N - X-ray MuPIT 3U5O - X-ray MuPIT 3U5P - X-ray MuPIT
3UEE - X-ray MuPIT 3UEF - X-ray MuPIT 3UIG - X-ray MuPIT
3UII - X-ray MuPIT 3UIK - X-ray MuPIT 3V43 - X-ray MuPIT
4A0J - X-ray 4A0N - X-ray 4A7J - X-ray MuPIT
4F4U - X-ray MuPIT 4F56 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P68431
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031492 nucleosomal DNA binding
GO:0045296 cadherin binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0000183 chromatin silencing at rDNA
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0007596 blood coagulation
GO:0032200 telomere organization
GO:0038111 interleukin-7-mediated signaling pathway
GO:0044267 cellular protein metabolic process
GO:0045652 regulation of megakaryocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0051290 protein heterotetramerization
GO:0060964 regulation of gene silencing by miRNA
GO:0060968 regulation of gene silencing

Cellular Component:
GO:0000228 nuclear chromosome
GO:0000786 nucleosome
GO:0000788 nuclear nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 macromolecular complex
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC067494 - Homo sapiens histone cluster 1, H3i, mRNA (cDNA clone IMAGE:7002080), containing frame-shift errors.
BC066884 - Homo sapiens histone cluster 1, H3i, mRNA (cDNA clone MGC:79346 IMAGE:7002077), complete cds.
BC067493 - Homo sapiens histone cluster 1, H3i, mRNA (cDNA clone MGC:79347 IMAGE:7002079), complete cds.
LP896418 - Sequence 1282 from Patent EP3253886.
JD295847 - Sequence 276871 from Patent EP1572962.
BC069305 - Homo sapiens histone cluster 1, H3i, mRNA (cDNA clone MGC:97469 IMAGE:7262745), complete cds.
JD380478 - Sequence 361502 from Patent EP1572962.
KJ897831 - Synthetic construct Homo sapiens clone ccsbBroadEn_07225 HIST1H3I gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05322 - Systemic lupus erythematosus

Reactome (by CSHL, EBI, and GO)

Protein P68431 (Reactome details) participates in the following event(s):

R-HSA-3301237 KAT2 complexes acetylate histone H3
R-HSA-3318486 KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3
R-HSA-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)
R-HSA-5159245 SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)
R-HSA-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)
R-HSA-5218952 PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)
R-HSA-5225649 RBBP7 binds histone H3
R-HSA-5634750 EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)
R-HSA-5638332 PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)
R-HSA-5638333 WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)
R-HSA-5649801 DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)
R-HSA-3214912 KDM1A, KDM1B demethylate MeK5-histone H3
R-HSA-4722133 KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3
R-HSA-4724284 KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3
R-HSA-4754176 JMJD6 demethylates MeR3-histone H3
R-HSA-994106 HP1 alpha binds Histone H3K9(me)3
R-HSA-5634729 EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)
R-HSA-4724279 KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3
R-HSA-5661115 KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3
R-HSA-3318413 KAT7-containing ING4/5 complexes acetylate Me3K-histone H3
R-HSA-4827382 SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)
R-HSA-5661120 KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3
R-HSA-4754181 KDM5A-D demethylate Me2K5-histone H3
R-HSA-5244692 Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)
R-HSA-5661123 KDM1A, KDM1B demethylate Me2K5-histone H3
R-HSA-5637686 WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)
R-HSA-5661116 KDM5A-D demethylate Me3K5-histone H3
R-HSA-5638141 SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)
R-HSA-5661114 KDM2A, KDM2B, KDM4A, KDM8 demethylate Me2K37-histone H3
R-HSA-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)
R-HSA-5661121 KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3
R-HSA-5649802 WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)
R-HSA-4754187 KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3
R-HSA-5649800 WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)
R-HSA-5661117 CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3
R-HSA-5225602 WDR5 binds Me2sR3-replicative histone H3
R-HSA-5661122 JMJD6 demethylates Me2R3-histone H3
R-HSA-5649799 DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)
R-HSA-5649764 DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)
R-HSA-5634802 MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)
R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
R-HSA-997263 JMJD1C demethylates H3K9 mono- and di-methylation
R-HSA-3301345 Elongator complex acetylates replicative histone H3, H4
R-HSA-3697920 CLOCK acetylates lysine-10 of histone H3, H4
R-NUL-4549261 Elongator complex acetylates H3, H4
R-NUL-4568946 Clock acetylates histones H3, H4
R-HSA-5144542 CLOCK acetylates lysine-15 of histone H3, H4
R-HSA-3697008 CREBBP acetylates histone H2B, H3, H4
R-HSA-3662335 EP300 acetylates histone H2A, H2B, H3, H4
R-HSA-5205822 CARM1 methylates arginine-18 (H3R17) of histone H3
R-HSA-5229010 CARM1 methylates arginine-27 of histone H3 (H3R26)
R-HSA-5205824 CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)
R-HSA-1214188 PRDM9 trimethylates histone H3
R-HSA-8935730 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter
R-HSA-8935740 RUNX1 and GATA1 bind the promoter of the ITGA2B gene
R-HSA-8936599 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter
R-HSA-8936616 RUNX1 and GATA1 bind the promoter of the GP1BA gene
R-HSA-8936979 RUNX1 and GATA1 bind the promoter of the THBS1 gene
R-HSA-8936989 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter
R-HSA-8937037 RUNX1 and GATA1 bind the promoter of the MIR27A gene
R-HSA-8937118 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter
R-HSA-3247569 PADI4 deiminates Histones
R-HSA-8865613 BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3
R-HSA-427336 TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
R-HSA-427527 eNoSC dimethylates histone H3 at lysine-9
R-HSA-5334164 DNMT3B:DNMT3L binds chromatin
R-HSA-5334179 DNMT3A:DNMT3L binds chromatin
R-HSA-5578742 AGO1,2:small RNA complexes interact with chromatin
R-HSA-427514 eNoSC deacetylates histone H3
R-HSA-3240295 PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter
R-HSA-3222593 KDM6B demethylates H3K27me3 on p16-INK4A promoter
R-HSA-3788748 EHMT1:EHMT2 methylates IL6 promoter
R-HSA-3788745 EHMT1:EHMT2 methylates IL8 promoter
R-HSA-5334151 DNMT1 methylates cytosine in hemimethylated DNA
R-HSA-5334160 UHRF1:Chromatin binds DNMT1
R-HSA-5334099 UHRF1 binds chromatin with hemimethylated cytosine
R-HSA-8865491 RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene
R-HSA-9011949 KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers
R-HSA-9011981 EP300 is recruited to MYC and BCL2 genes
R-HSA-9011985 KDM1A demethylates H3 on MYC and BCL genes in response to estrogen
R-HSA-3364026 SET1 complex trimethylates H3K4 at the MYC gene
R-HSA-3769447 HDAC1/2 containing-complexes deacetylate histones
R-HSA-3777129 HDAC3 containing complexes deacetylate histone
R-HSA-3782637 HDAC8 deacetylates histones
R-HSA-3782655 HDAC10 deacetylates histone
R-HSA-3229089 PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter
R-HSA-3229102 p-MAPKAPK3 phosphorylates BMI1
R-HSA-427383 CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9
R-HSA-427528 Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)
R-HSA-5227490 NoRC:HDAC:DNMT methylates cytosine of the rRNA genes
R-HSA-427337 MBD2 binds methylcytosine in chromatin
R-HSA-9011983 Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes
R-HSA-9011984 KDM1A is recruited to MYC and BCL2 genes
R-HSA-5625774 PKN1:AR complex binds promoters of KLK2 and KLK3 genes
R-HSA-9011952 ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers
R-HSA-8936584 PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
R-HSA-8936481 Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter
R-HSA-8936608 PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter
R-HSA-8936621 Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
R-HSA-8937016 Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
R-HSA-8937022 PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
R-HSA-8937050 Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter
R-HSA-8937113 PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter
R-HSA-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter
R-HSA-9009065 FOXA1 and GATA3 bind to CCND1 promoter
R-HSA-2288097 Condensin II complex binds H4K20me1-containing nucleosomes
R-HSA-2245218 CDK1 phosphorylates PHF8
R-HSA-5625849 Demethylase KDM1A binds KLK2 and KLK3 promoters
R-HSA-5625797 KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters
R-HSA-5625870 KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters
R-HSA-212263 PRC2 trimethylates histone H3 at lysine-27
R-HSA-212222 PRC2 recruits DNA methyltransferases
R-HSA-5334097 DNMT3B:DNMT3L methylates cytosine in DNA
R-HSA-5334152 DNMT3A:DNMT3L methylates cytosine in DNA
R-HSA-8865498 KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark
R-HSA-5625784 PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
R-HSA-977224 Serum amyloid P binds DNA and chromatin
R-HSA-2172678 PHF8 demethylates histone H4K20me1
R-HSA-2301205 SETD8 monomethylates histone H4
R-HSA-2294600 CDK1 phosphorylates condensin II subunit NCAPD3
R-HSA-2294580 PLK1 hyperphosphorylates Condensin II complex
R-HSA-2294590 PLK1 binds phosphorylated condensin II complex
R-HSA-5625796 Demethylase KDM4C binds KLK2 and KLK3 promoters
R-HSA-5625848 KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
R-HSA-3214847 HATs acetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3214842 HDMs demethylate histones
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-109582 Hemostasis
R-HSA-912446 Meiotic recombination
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-1266695 Interleukin-7 signaling
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3214815 HDACs deacetylate histones
R-HSA-4839726 Chromatin organization
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-1500620 Meiosis
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-449147 Signaling by Interleukins
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-211000 Gene Silencing by RNA
R-HSA-2559583 Cellular Senescence
R-HSA-8939211 ESR-mediated signaling
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-977225 Amyloid fiber formation
R-HSA-1474165 Reproduction
R-HSA-1640170 Cell Cycle
R-HSA-212436 Generic Transcription Pathway
R-HSA-68875 Mitotic Prophase
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-74160 Gene expression (Transcription)
R-HSA-2262752 Cellular responses to stress
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-195721 Signaling by WNT
R-HSA-1266738 Developmental Biology
R-HSA-195258 RHO GTPase Effectors
R-HSA-392499 Metabolism of proteins
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-68886 M Phase
R-HSA-168256 Immune System
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-69278 Cell Cycle (Mitotic)

-  Other Names for This Gene
  Alternate Gene Symbols: A0PJT7, A5PLR1, H31_HUMAN, H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3J, NM_003533, NP_066298, P02295, P02296, P16106, P68431, Q6ISV8, Q6NWP8, Q6NWP9, Q6NXU4, Q71DJ3, Q93081
UCSC ID: uc003njy.3
RefSeq Accession: NM_003533
Protein: P68431 (aka H31_HUMAN)
CCDS: CCDS4636.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_003533.2
exon count: 1CDS single in 3' UTR: no RNA size: 477
ORF size: 411CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1022.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.