Human Gene NKAP (uc004esh.3) Description and Page Index
Description: Homo sapiens NFKB activating protein (NKAP), mRNA. RefSeq Summary (NM_024528): This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]. ##Evidence-Data-START## Transcript exon combination :: AK026279.1, AY388958.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371410.5/ ENSP00000360464.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chrX:119,059,013-119,077,735 Size: 18,723 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chrX:119,059,183-119,077,568 Size: 18,386 Coding Exon Count: 9
ID:NKAP_HUMAN DESCRIPTION: RecName: Full=NF-kappa-B-activating protein; FUNCTION: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. SUBUNIT: Component of the Notch corepressor complex. Interacts with CIR1 and HDAC3. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the UPF0396 family. SEQUENCE CAUTION: Sequence=AAH71686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): NKAP CDC HuGE Published Literature: NKAP
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06047 - Ras-induced vulval development antagonist PF15692 - NF-kappa-B-activating protein
ModBase Predicted Comparative 3D Structure on Q8N5F7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.