Human Gene OTUD6B (uc003yeu.4) Description and Page Index
  Description: Homo sapiens OTU domain containing 6B (OTUD6B), mRNA.
RefSeq Summary (NM_016023): This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013].
Transcript (Including UTRs)
   Position: hg19 chr8:92,082,424-92,099,323 Size: 16,900 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr8:92,082,523-92,097,096 Size: 14,574 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:92,082,424-92,099,323)mRNA (may differ from genome)Protein (323 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=OTU domain-containing protein 6B; AltName: Full=DUBA-5;
SIMILARITY: Contains 1 OTU domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: OTUD6B
Diseases sorted by gene-association score: intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies* (900), alacrima, achalasia, and mental retardation syndrome* (231), visual epilepsy* (200), seizure disorder* (163), intellectual disability* (85)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.16 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 201.74 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.7099-0.411 Picture PostScript Text
3' UTR -484.452227-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003323 - OTU

Pfam Domains:
PF02338 - OTU-like cysteine protease
PF10275 - Peptidase C65 Otubain

SCOP Domains:
54001 - Cysteine proteinases

ModBase Predicted Comparative 3D Structure on Q8N6M0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserGenome Browser
Gene Details   Gene DetailsGene Details
Gene Sorter   Gene SorterGene Sorter
  Ensembl WormBaseSGD
  Protein Sequence Protein SequenceProtein Sequence
  Alignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0008283 cell proliferation
GO:0016579 protein deubiquitination
GO:0017148 negative regulation of translation
GO:0043248 proteasome assembly
GO:0045727 positive regulation of translation

Cellular Component:
GO:0016281 eukaryotic translation initiation factor 4F complex

-  Descriptions from all associated GenBank mRNAs
  BX647772 - Homo sapiens mRNA; cDNA DKFZp686N2259 (from clone DKFZp686N2259).
AK293843 - Homo sapiens cDNA FLJ60450 complete cds, highly similar to OTU domain-containing protein 6B.
LF206452 - JP 2014500723-A/13955: Polycomb-Associated Non-Coding RNAs.
BC029760 - Homo sapiens OTU domain containing 6B, mRNA (cDNA clone MGC:16950 IMAGE:4343258), complete cds.
AK310823 - Homo sapiens cDNA, FLJ17865.
AK291646 - Homo sapiens cDNA FLJ75719 complete cds, highly similar to Homo sapiens OTU domain containing 6B (OTUD6B), mRNA.
AF151836 - Homo sapiens CGI-77 protein mRNA, complete cds.
KJ902608 - Synthetic construct Homo sapiens clone ccsbBroadEn_12002 OTUD6B gene, encodes complete protein.
LF354578 - JP 2014500723-A/162081: Polycomb-Associated Non-Coding RNAs.
LF354577 - JP 2014500723-A/162080: Polycomb-Associated Non-Coding RNAs.
AL137441 - Homo sapiens mRNA; cDNA DKFZp761P2124 (from clone DKFZp761P2124).
LF354576 - JP 2014500723-A/162079: Polycomb-Associated Non-Coding RNAs.
LF354575 - JP 2014500723-A/162078: Polycomb-Associated Non-Coding RNAs.
LF354574 - JP 2014500723-A/162077: Polycomb-Associated Non-Coding RNAs.
LF354573 - JP 2014500723-A/162076: Polycomb-Associated Non-Coding RNAs.
LF354572 - JP 2014500723-A/162075: Polycomb-Associated Non-Coding RNAs.
LF354571 - JP 2014500723-A/162074: Polycomb-Associated Non-Coding RNAs.
MA442029 - JP 2018138019-A/13955: Polycomb-Associated Non-Coding RNAs.
MA590155 - JP 2018138019-A/162081: Polycomb-Associated Non-Coding RNAs.
MA590154 - JP 2018138019-A/162080: Polycomb-Associated Non-Coding RNAs.
MA590153 - JP 2018138019-A/162079: Polycomb-Associated Non-Coding RNAs.
MA590152 - JP 2018138019-A/162078: Polycomb-Associated Non-Coding RNAs.
MA590151 - JP 2018138019-A/162077: Polycomb-Associated Non-Coding RNAs.
MA590150 - JP 2018138019-A/162076: Polycomb-Associated Non-Coding RNAs.
MA590149 - JP 2018138019-A/162075: Polycomb-Associated Non-Coding RNAs.
MA590148 - JP 2018138019-A/162074: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K6I1, CGI-77, DUBA5, NM_016023, NP_057107, OTU6B_HUMAN, Q8N6M0, Q9NTA4, Q9Y387
UCSC ID: uc003yeu.4
RefSeq Accession: NM_016023
Protein: Q8N6M0 (aka OTU6B_HUMAN)
CCDS: CCDS6253.2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_016023.3
exon count: 7CDS single in 3' UTR: no RNA size: 3306
ORF size: 972CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2144.00frame shift in genome: no % Coverage: 99.76
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.