ID:RPA43_HUMAN DESCRIPTION: RecName: Full=DNA-directed RNA polymerase I subunit RPA43; AltName: Full=Twist neighbor protein; FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with RRN3/TIF-IA. SUBCELLULAR LOCATION: Nucleus, nucleolus (By similarity). TISSUE SPECIFICITY: Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in fetal lung, liver, and kidney, and low expression in all adult tissues. SIMILARITY: Belongs to the eukaryotic RPA43 RNA polymerase subunit family. SEQUENCE CAUTION: Sequence=AAH14574.1; Type=Frameshift; Positions=224;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03876 - SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
ModBase Predicted Comparative 3D Structure on Q3B726
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-73865 Assembly of RNA Polymerase I Holoenzyme (human) R-HSA-73757 Binding of RRN3 to RNA Polymerase I R-HSA-5250947 B-WICH complex binds rDNA promoter R-HSA-73758 Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter R-HSA-74994 Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box R-HSA-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex R-HSA-74992 Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box R-HSA-5250930 B-WICH recruits histone acetyltransferases R-HSA-74993 PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box R-HSA-74986 Elongation of pre-rRNA transcript R-HSA-427366 Transcription of intergenic spacer of the rRNA gene R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-73854 RNA Polymerase I Promoter Clearance R-HSA-73863 RNA Polymerase I Transcription Termination R-HSA-73772 RNA Polymerase I Promoter Escape R-HSA-5250913 Positive epigenetic regulation of rRNA expression R-HSA-73864 RNA Polymerase I Transcription R-HSA-73777 RNA Polymerase I Chain Elongation R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-212165 Epigenetic regulation of gene expression R-HSA-74160 Gene expression (Transcription) R-HSA-5250941 Negative epigenetic regulation of rRNA expression