Human Gene MOB1B (uc003hfw.3) Description and Page Index
  Description: Homo sapiens MOB kinase activator 1B (MOB1B), transcript variant 2, mRNA.
RefSeq Summary (NM_173468): The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Transcript (Including UTRs)
   Position: hg19 chr4:71,768,057-71,853,891 Size: 85,835 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr4:71,768,254-71,847,774 Size: 79,521 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:71,768,057-71,853,891)mRNA (may differ from genome)Protein (216 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MOB1B_HUMAN
DESCRIPTION: RecName: Full=MOB kinase activator 1B; AltName: Full=Mob1 homolog 1A; Short=Mob1A; AltName: Full=Mob1B; AltName: Full=Mps one binder kinase activator-like 1A;
FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
SUBUNIT: Binds STK38L. Interacts with LATS1 and LATS2.
INTERACTION: O95835:LATS1; NbExp=2; IntAct=EBI-2558745, EBI-444209; Q9NRM7:LATS2; NbExp=2; IntAct=EBI-2558745, EBI-3506895;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.
PTM: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
SIMILARITY: Belongs to the MOB1/phocein family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.66 RPKM in Kidney - Cortex
Total median expression: 226.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.40197-0.251 Picture PostScript Text
3' UTR -1504.906117-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005301 - Mob1_phocein

Pfam Domains:
PF03637 - Mob1/phocein family

SCOP Domains:
101152 - Mob1/phocein

ModBase Predicted Comparative 3D Structure on Q7L9L4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019209 kinase activator activity
GO:0019900 kinase binding
GO:0046872 metal ion binding

Biological Process:
GO:0031952 regulation of protein autophosphorylation
GO:0035329 hippo signaling
GO:0042327 positive regulation of phosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK093545 - Homo sapiens cDNA FLJ36226 fis, clone THYMU2001018, highly similar to Mps one binder kinase activator-like 1A.
AX748194 - Sequence 1719 from Patent EP1308459.
AK299481 - Homo sapiens cDNA FLJ52228 complete cds, highly similar to Mps one binder kinase activator-like 1A.
BC038112 - Homo sapiens MOB1, Mps One Binder kinase activator-like 1A (yeast), mRNA (cDNA clone MGC:33910 IMAGE:5264730), complete cds.
AK313513 - Homo sapiens cDNA, FLJ94071, Homo sapiens Mob4A protein (MOB4A), mRNA.
CU691542 - Synthetic construct Homo sapiens gateway clone IMAGE:100016791 5' read MOBKL1A mRNA.
KJ895189 - Synthetic construct Homo sapiens clone ccsbBroadEn_04583 MOB1B gene, encodes complete protein.
AJ577473 - Homo sapiens mRNA for Mob4A protein.
JD525994 - Sequence 507018 from Patent EP1572962.
JD120034 - Sequence 101058 from Patent EP1572962.
JD154054 - Sequence 135078 from Patent EP1572962.
JD146399 - Sequence 127423 from Patent EP1572962.
JD560444 - Sequence 541468 from Patent EP1572962.
JD241329 - Sequence 222353 from Patent EP1572962.
JD235263 - Sequence 216287 from Patent EP1572962.
JD546203 - Sequence 527227 from Patent EP1572962.
JD162230 - Sequence 143254 from Patent EP1572962.
JD520044 - Sequence 501068 from Patent EP1572962.
JD436775 - Sequence 417799 from Patent EP1572962.
JD506781 - Sequence 487805 from Patent EP1572962.
JD566429 - Sequence 547453 from Patent EP1572962.
JD434317 - Sequence 415341 from Patent EP1572962.
JD558052 - Sequence 539076 from Patent EP1572962.
JD265109 - Sequence 246133 from Patent EP1572962.
JD173869 - Sequence 154893 from Patent EP1572962.
JD326470 - Sequence 307494 from Patent EP1572962.
JD553666 - Sequence 534690 from Patent EP1572962.
JD530236 - Sequence 511260 from Patent EP1572962.
JD309477 - Sequence 290501 from Patent EP1572962.
JD188905 - Sequence 169929 from Patent EP1572962.
JD038400 - Sequence 19424 from Patent EP1572962.
JD109565 - Sequence 90589 from Patent EP1572962.
JD554671 - Sequence 535695 from Patent EP1572962.
JD491006 - Sequence 472030 from Patent EP1572962.
JD237266 - Sequence 218290 from Patent EP1572962.
JD081925 - Sequence 62949 from Patent EP1572962.
BC044913 - Homo sapiens MOB1, Mps One Binder kinase activator-like 1A (yeast), mRNA (cDNA clone IMAGE:5286410).
AL162039 - Homo sapiens mRNA; cDNA DKFZp434M229 (from clone DKFZp434M229).
JD137198 - Sequence 118222 from Patent EP1572962.
JD103466 - Sequence 84490 from Patent EP1572962.
JD245510 - Sequence 226534 from Patent EP1572962.
JD245260 - Sequence 226284 from Patent EP1572962.
JD236935 - Sequence 217959 from Patent EP1572962.
JD272164 - Sequence 253188 from Patent EP1572962.
JD198626 - Sequence 179650 from Patent EP1572962.
JD153676 - Sequence 134700 from Patent EP1572962.
JD428417 - Sequence 409441 from Patent EP1572962.
JD426752 - Sequence 407776 from Patent EP1572962.
JD344541 - Sequence 325565 from Patent EP1572962.
JD374525 - Sequence 355549 from Patent EP1572962.
JD489085 - Sequence 470109 from Patent EP1572962.
JD489086 - Sequence 470110 from Patent EP1572962.
JD072248 - Sequence 53272 from Patent EP1572962.
JD364154 - Sequence 345178 from Patent EP1572962.
JD242839 - Sequence 223863 from Patent EP1572962.
JD064533 - Sequence 45557 from Patent EP1572962.
JD512075 - Sequence 493099 from Patent EP1572962.
JD506277 - Sequence 487301 from Patent EP1572962.
JD374337 - Sequence 355361 from Patent EP1572962.
JD232896 - Sequence 213920 from Patent EP1572962.
JD053861 - Sequence 34885 from Patent EP1572962.
JD306111 - Sequence 287135 from Patent EP1572962.
JD410220 - Sequence 391244 from Patent EP1572962.
JD091936 - Sequence 72960 from Patent EP1572962.
JD299205 - Sequence 280229 from Patent EP1572962.
JD042246 - Sequence 23270 from Patent EP1572962.
JD509264 - Sequence 490288 from Patent EP1572962.
JD536312 - Sequence 517336 from Patent EP1572962.
JD359665 - Sequence 340689 from Patent EP1572962.
JD154888 - Sequence 135912 from Patent EP1572962.
JD486466 - Sequence 467490 from Patent EP1572962.
JD225032 - Sequence 206056 from Patent EP1572962.
JD333689 - Sequence 314713 from Patent EP1572962.
JD553693 - Sequence 534717 from Patent EP1572962.
JD244488 - Sequence 225512 from Patent EP1572962.
JD109984 - Sequence 91008 from Patent EP1572962.
JD503582 - Sequence 484606 from Patent EP1572962.
JD303453 - Sequence 284477 from Patent EP1572962.
JD546826 - Sequence 527850 from Patent EP1572962.
JD047369 - Sequence 28393 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7L9L4 (Reactome details) participates in the following event(s):

R-HSA-2028629 Phosphorylation of MOB1A and B by p-STK4 (p-MST1)
R-HSA-2028635 Phosphorylation of MOB1A and B by p-STK3 (p-MST2)
R-HSA-2028670 Phosphorylation of MOB1A and B by p-STK4(MST1)/N
R-HSA-2028675 Phosphorylation of MOB1A and B by p-STK3(MST2)/N
R-HSA-2028626 Phosphorylated MOB1A proteins associate with LATS proteins
R-HSA-2028555 Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
R-HSA-2028589 Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
R-HSA-2028673 Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
R-HSA-2028679 Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
R-HSA-2028598 Phosphorylation of YAP by LATS1
R-HSA-2060328 Phosphorylation of WWTR1 (TAZ) by LATS1
R-HSA-2028583 Phosphorylation of YAP by LATS2
R-HSA-2028661 Phosphorylation of WWTR1 (TAZ) by LATS2
R-HSA-2028269 Signaling by Hippo
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R8U6, MOB1B_HUMAN, MOB4A, MOBKL1A, NM_173468, NP_775739, Q7L9L4, Q8IY23
UCSC ID: uc003hfw.3
RefSeq Accession: NM_173468
Protein: Q7L9L4 (aka MOB1B_HUMAN)
CCDS: CCDS58903.1, CCDS34002.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_173468.3
exon count: 6CDS single in 3' UTR: no RNA size: 6979
ORF size: 651CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1376.00frame shift in genome: no % Coverage: 99.80
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.