Human Gene ZBTB11 (uc003dve.4) Description and Page Index
  Description: Homo sapiens zinc finger and BTB domain containing 11 (ZBTB11), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:101,368,283-101,395,988 Size: 27,706 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr3:101,370,010-101,395,758 Size: 25,749 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:101,368,283-101,395,988)mRNA (may differ from genome)Protein (1053 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 11;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 12 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.71 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 227.48 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -91.30230-0.397 Picture PostScript Text
3' UTR -409.261727-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
54695 - POZ domain
57667 - C2H2 and C2HC zinc fingers
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on O95625
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm

-  Descriptions from all associated GenBank mRNAs
  AK023488 - Homo sapiens cDNA FLJ13426 fis, clone PLACE1002450, highly similar to Zinc finger and BTB domain-containing protein11.
AB208862 - Homo sapiens mRNA for zinc finger protein ZNF-U69274 variant protein.
BC029342 - Homo sapiens zinc finger and BTB domain containing 11, mRNA (cDNA clone IMAGE:3924878).
U69274 - Human zinc finger protein mRNA, complete cds.
JD554688 - Sequence 535712 from Patent EP1572962.
JD110634 - Sequence 91658 from Patent EP1572962.
JD176082 - Sequence 157106 from Patent EP1572962.
JD496793 - Sequence 477817 from Patent EP1572962.
BC111700 - Homo sapiens zinc finger and BTB domain containing 11, mRNA (cDNA clone MGC:133303 IMAGE:40038346), complete cds.
JD327487 - Sequence 308511 from Patent EP1572962.
JD502001 - Sequence 483025 from Patent EP1572962.
JD229354 - Sequence 210378 from Patent EP1572962.
JD526422 - Sequence 507446 from Patent EP1572962.
JD097961 - Sequence 78985 from Patent EP1572962.
JD507956 - Sequence 488980 from Patent EP1572962.
AK312859 - Homo sapiens cDNA, FLJ93302, highly similar to Homo sapiens zinc finger and BTB domain containing 11 (ZBTB11), mRNA.
BC028062 - Homo sapiens zinc finger and BTB domain containing 11, mRNA (cDNA clone IMAGE:5189665), with apparent retained intron.
LF210630 - JP 2014500723-A/18133: Polycomb-Associated Non-Coding RNAs.
JD190326 - Sequence 171350 from Patent EP1572962.
JD104944 - Sequence 85968 from Patent EP1572962.
MA446207 - JP 2018138019-A/18133: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_014415, NP_055230, O95625, Q2NKP9, ZBT11_HUMAN
UCSC ID: uc003dve.4
RefSeq Accession: NM_014415
Protein: O95625 (aka ZBT11_HUMAN or ZB11_HUMAN)
CCDS: CCDS2943.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_014415.3
exon count: 11CDS single in 3' UTR: no RNA size: 5132
ORF size: 3162CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5300.00frame shift in genome: no % Coverage: 99.75
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.